Paracoccidioidomycosis is an infection caused by the fungus Paracoccidioides. This fungus lives in parts of Central and South America. Anyone who lives in or visits areas where Paracoccidioides lives can get paracoccidioidomycosis, but it most often affects men who work outdoors in rural areas. 1
- Lesions in the mouth and throat
- Weight loss
- Swollen lymph nodes
- Shortness of breath
- Enlarged liver and spleen
The symptoms of paracoccidioidomycosis can be different for different groups of people. 3,4 In adults, paracoccidioidomycosis usually affects the lungs and causes lesions in the mouth and throat. Children are more likely to have swollen lymph nodes and skin lesions.
Paracoccidioidomycosis can occur in healthy people and people with weakened immune systems. In people with weakened immune systems (for example, due to HIV/AIDS), the symptoms usually get worse more quickly. 5
Risk and Prevention
Who gets paracoccidioidomycosis?
Anyone who lives in or visits areas where Paracoccidioides lives can get paracoccidioidomycosis, but it most often affects men who work outdoors in rural areas of Central and South America. 1 In children, boys and girls are equally likely to get paracoccidioidomycosis. Most cases of paracoccidioidomycosis occur in Brazil, Venezuela, Colombia, and Argentina. 1,2
How can I prevent paracoccidioidomycosis?
It’s difficult to avoid breathing in the fungus that causes paracoccidioidomycosis in areas where it’s common in the environment. Many people who breathe in this fungus never get sick from it.
People get paracoccidioidomycosis after breathing in the fungus Paracoccidioides from the environment in certain parts of Central and South America. Paracoccidioidomycosis does not spread from person to person. The exact time between inhaling the fungus and getting paracoccidioidomycosis is not known, but scientists believe that many people are exposed to the fungus as children in areas where it’s common in the environment.
Diagnosis and Testing
Healthcare providers use a patient’s symptoms as well as laboratory tests and imaging tests, such as a chest X-ray, to diagnose paracoccidioidomycosis. 7 Often, a healthcare provider will perform a biopsy, which is a small sample from the body part that is affected. The sample is sent to a laboratory for a fungal culture or to be examined under the microscope. A blood test can also help diagnose paracoccidioidomycosis.
Paracoccidioidomycosis can be treated with antifungal medicines such as itraconazole and amphotericin B. 7 Another medicine often used to treat paracoccidioidomycosis is trimethoprim/sulfamethoxazole (TMP/SMX), which is also known as co-trimoxazole and by several different brand names, including Bactrim, Septra, and Cotrim. Patients usually need treatment for about one year.
More than 15,000 cases of paracoccidioidomycosis have been recorded since 1930. Many more cases likely occur, however, because the disease is underrecognized. 1 About 80% of recorded cases have occurred in Brazil. 1,2 Paracoccidioidomycosis is probably rare in the United States, where it is not a reportable disease. Scientists estimate that less than 5% of patients with paracoccidioidomycosis die from the disease. 2
- Martinez R. Epidemiology of paracoccidioidomycosisexternal icon. Rev Inst Med Trop Sao Paulo 2015;57 Suppl 19:11-20.
- Martinez R. New trends in paracoccidioidomycosis epidemiologyexternal icon. J Fungi (Basel) 2017;3.
- Bellissimo-Rodrigues F, Bollela VR, Da Fonseca BA, Martinez R. Endemic paracoccidioidomycosis: relationship between clinical presentation and patients’ demographic featuresexternal icon. Med Mycol 2013;51:313-8.
- Paniago AM, Aguiar JI, Aguiar ES, de Cunha VR, de Oliveira Leida Pereira GR, Londer AT, et al. Paracoccidioidomycosis: a clinical and epidemiological study of 422 cases observed in Mato Grosso do Sulexternal icon. Rev Soc Bras Med Trop 2003;36:455-9.
- Morejon KM, Machado AA, Martinez R. Paracoccidioidomycosis in patients infected with and not infected with human immunodeficiency virus: a case-control studyexternal icon. Am J Trop Med Hyg 2009;80:359-66.
- Arantes TD, Theodoro RC, Teixeira Mde M, Bosco Sde M, Bagagli E. Environmental mapping of Paracoccidioides spp. in Brazil reveals new clues into genetic diversity, biogeography and wild host associationexternal icon. PLoS Negl Trop Dis 2016;10:e0004606.
- Shikanai-Yasuda MA, Mendes RP, Colombo AL, Queiroz-Telles F, Kono ASG, Paniago AMM, et al. Brazilian guidelines for the clinical management of paracoccidioidomycosisexternal icon. Rev Soc Bras Med Trop 2017;50:715-40.