Leading Progress to End the Global HIV Epidemic

More than four decades since the first cases were reported, HIV is still a leading cause of death and a health threat to millions worldwide. While innovations in HIV care, treatment, and prevention now help people with HIV to enjoy longer, healthier lives, many people are not benefiting from the latest scientific advances, mainly due to stigma and discrimination. Strong partnerships, dedication to eliminating stigma and discrimination, and ensuring equitable access to quality, people-centered HIV services, remain central to sustaining progress and ending HIV as an epidemic. This requires the equitable use of effective treatment and prevention programs focusing on populations disproportionately impacted by HIV.

As a key implementing partner of the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR), CDC works side-by-side with ministries of health, civil and faith-based organizations, private sector, and other on-the-ground partners to improve methods for finding, treating, and preventing HIV. The investments made today will save lives, strengthen communities, and pave the way for long-term sustainability.

Eliminating HIV as a Global Public Health Threat

CDC On The Frontlines - Global HIV

In 2003, the U.S. President’s Emergency Plan for AIDS Relief, or PEPFAR, was announced. When it was launched, PEPFAR became the largest commitment by any nation to address a single disease in history. At the time, HIV was a global crisis, devastating families, communities, and economies worldwide—particularly in sub-Saharan African countries.

As a key implementing agency of PEPFAR, CDC has played a critical role since its inception, bringing more than four decades of scientific and technical expertise to bear in the global fight against HIV.

A new analysis published this week in CDC’s Morbidity and Mortality Weekly Report reveals that, since 2004, a year after it was launched, the number of people with HIV receiving lifesaving treatment through PEPFAR increased an astonishing 300 times — from just 66,500 individuals in 2004 to more than 20 million people in 2022.

Tracking Impact

CDC On The Frontlines - Global HIV
The Population-Based HIV Impact Assessments (PHIAs) surveys are an important tool for measuring the impact of HIV treatment and prevention programs in PEPFAR-supported countries. CDC and partners apply analytical insights from PHIAs to make timely adjustments to programs, leading to increased efficiencies and positive outcomes for community members, including people living with HIV. Learn more about PHIAs and the countries where surveys have been completed.

Latest Research

Latest research from CDC on global HIV and TB.


An overview of CDC’s global efforts in response to one of the world’s greatest health threats.

DGHT overview resource-cover
CDC’s role in the global HIV response.
DGHT overview resource-cover
HIV Drug Resistance with CADRE