Controlling the Global HIV Epidemic

Four decades after the first cases were reported, HIV is still a leading cause of death and a health threat to millions worldwide. Today, the world has the tools needed to control the HIV epidemic and lay the groundwork for ending this disease. However, many people are not benefiting from the latest scientific advances. Controlling the HIV epidemic requires the equitable use of effective treatment and prevention programs focusing on populations disproportionately impacted by HIV.

As a key implementing partner of the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR), CDC works side-by-side with ministries of health, civil and faith-based organizations, private sector organizations, and other on-the-ground partners to improve methods for finding, treating, and preventing HIV. The investments made today in response to HIV will save lives, strengthen communities, and pave the way for long-term sustainability.

CDC’s Contributions

Statement from CDC leaders on progress toward HIV epidemic control.

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Antiretroviral Treatment for Men, Women, and Children**

PEPFAR: 18.9 Million

CDC: 11.8 Million

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Voluntary Medical Male Circumcisions (VMMC)****

PEPFAR: 27.7 Million

CDC: 14.3 Million

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People Who Received a Positive HIV Test Result***

PEPFAR: 2.5 Million

CDC: 1.5 Million

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HIV-Positive Persons Screened in Care for TB***

PEPFAR: 15.5 Million

CDC: 9.5 Million

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Antiretroviral Treatment to Prevent Mother-to-child Transmission***

PEPFAR: 756,000

CDC: 481,000

Sources: U.S. President’s Emergency Plan for AIDS Relief (PEPFAR)external icon

*Other USG agencies may have also contributed to some of these achievements **As of Sept 30, 2021 ***FY2021 ****Cumulative through Sept 30, 2021

Accelerating Epidemic Control in South Africa

Siyenza. PEPFAR-led initiative designed to rapidly accerate South Africa's progress toward global epidemic control targets.CDC is supporting Siyenza, a results-oriented initiative that’s laser-focused on scaling up proven public health interventions at the clinical level. Siyenza (an isiZulu word meaning “We are doing it”) is rapidly identifying people living with previously undiagnosed HIV, initiating them on lifesaving antiretroviral treatment, and finding innovative ways to retain them on treatment to achieve suppression of the virus. Read More

Feature Stories

Learn how CDC and partners adapted services to sustain and expand key HIV treatment and prevention activities during the COVID-19 pandemic.

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With support PEPFAR, DREAMS is comprised of a comprehensive, multi-sectoral package of core interventions that address key factors that make adolescent girls and young women (AGYW) particularly vulnerable to HIV.
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Despite advancements over several decades in the global HIV response, the onset of the COVID-19 pandemic introduced new challenges and threatened hard-won gains.
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In 2020, about 1.75 million children and adolescents between the ages of 10 and 19 were living with HIV (C/ALHIV) worldwide (UNAIDS 2021).

Partnering to End the HIV/AIDS Epidemic Worldwide

Dr. Minesh Shah

CDC’s Dr. Minesh Shah, an internal medicine physician and a medical officer in the Division of Global HIV and Tuberculosis, and Matsepo Mary-Anna Dee Mphafi, an HIV peer counselor in Lesotho with the Elizabeth Glaser Pediatric AIDS Foundation, discuss their inspiring work to fight HIV around the world as part of PEPFAR.

Social Media Tools

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The website describes how PEPFAR and CDC are leading efforts to accelerate controlling the HIV epidemic worldwide

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PEPFAR15 Page describing how pepfar played a critical role in an effort to save millions of lives across the globe

The PEPFAR15 page describes how for fifteen years, CDC has played a critical role in PEPFAR’s efforts to save millions of lives across the globe.

HIV Overview

The HIV overview provides a historical look at CDC’s leadership, reach, innovation and impact in the global fight against HIV.

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HIV Fact Sheet

The HIV fact sheet shows the burden of HIV worldwide and CDC’s efforts to address the epidemic.

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Page last reviewed: March 28, 2022, 03:46 PM