MPEP Mycobacterium Tuberculosis Drug Susceptibility Testing – Reports

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The Model Performance Evaluation Program (MPEP) is an educational self-assessment tool in which five isolates of M. tuberculosis complex (MTBC) are sent to participating laboratories biannually for staff to monitor their ability to determine drug resistance among the isolates. It is not a formal, graded proficiency testing program.

The reports include results for a subset of laboratories performing drug susceptibility tests (DST) for MTBC in the United States. MPEP is a voluntary program, and the reports reflect data received from participating laboratory personnel. The aggregate reports allow laboratory personnel to compare their DST results with those obtained by other participants using the same methods and drugs, for each isolate. CDC encourages circulation of the reports to personnel who are either involved with DST or reporting and interpreting results for MTBC isolates.

CDC is neither recommending nor endorsing testing practices reported by participants. For approved standards, participants should refer to consensus documents published by the Clinical and Laboratory Standards Institute (CLSI), “M24: Susceptibility Testing of Mycobacteria, Nocardiae spp., and Other Aerobic Actinomycetes” [1].

Use of trade names and commercial sources is for identification only and does not imply endorsement by the U.S. Department of Health and Human Services.

The findings and conclusions in this report are those of the author(s) and do not necessarily represent the views of the Centers for Disease Control and Prevention

Comments and inquiries regarding the reports should be directed to: