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AMD leads to better analysis and tracking of Cyclospora

Posted on Monday, May 13th, 2019

Micrograph showing circular oocysts of the parasite C. cayetanensis

Cyclospora cayetanensis is a particularly challenging pathogen to analyze, but thanks to AMD and a prototype typing tool that creates a “DNA fingerprint,” it may become easier for disease detectives to crack the code on Cyclospora outbreaks. CDC scientists are prepared to type samples in real time during the 2019 Cyclospora season to evaluate the new tool’s utility for outbreak detection. With this new tool, researchers hope to assist public health officials to detect more outbreaks and to learn how these pathogens are getting into the food system.

Building a Consensus on Genomic Software Needs in Public Health
Greg Armstrong and Duncan MacCannell outside of the Gates Foundation building in Seattle

Posted on Monday, April 8, 2019

The AMD program has partnered with the CDC Foundation and the Bill and Melinda Gates Foundation (BMGF) on a one-year project to define what software infrastructure is needed to support the complex information workflows required by AMD technologies.

In March, OAMD’s Greg Armstrong and Duncan MacCannell and NCIRD’s Elizabeth Neuhaus met with the project team, which also includes Africa CDC officials, Trevor Bedford’s laboratory at the University of Washington, and a group of experts in bioinformatics and open software development.  The group seeks consensus on a sustainable framework for this software—a framework that will facilitate the application of pathogen genomics to public health both in high-income countries such as the United States as well as in low- and middle-income countries.

AMD Director Greg Armstrong said, “It was remarkable how strongly the participants felt about the need for this meeting and for an effort to coordinate the development of software that will support pathogen genomics in public health.”

OAMD joins with CSTE and APHL to host AMD Academy

Posted on Monday, March 11, 2019

The Office of Advanced Molecular Detection (OAMD) welcomed epidemiologists and microbiologists from state and local health departments across the nation to the first AMD Academy, hosted with the Association of Public Health Laboratories (APHL) and the Council of State and Territorial Epidemiologists (CSTE). Held in Atlanta during the last week of January, OAMD presented a 2-day molecular epidemiology course for epidemiologists (January 30–31) and a 4-day, intermediate-level bioinformatics course for microbiologists (January 28–31).

New Article and Podcast on Next Generation Sequencing (NGS)
image of flow chart in JAMA Article

Posted on Tuesday, March 5, 2019

On February 14, the Journal of the American Medical Association (JAMA) published an articleexternal icon describing ongoing advances being made by CDC’s Advanced Molecular Detection (AMD) program in the field of next generation sequencing (NGS). JAMA also published a related clinical review podcastexternal icon, where they interviewed two of the authors, Marta Gwinn, MD, MPH, and Gregory L. Armstrong, MD, from the Office of AMD about the potential NGS holds for improving clinical and public health microbiology.

Page last reviewed: May 13, 2019