Clinical Care Guidance for Healthcare Professionals about Coronavirus (COVID-19)

Healthcare providers who have cared or are caring for patients younger than 21 years of age meeting multisystem inflammatory syndrome in children (MIS-C) criteria should report suspected cases to their local, state, or territorial health department.

For additional reporting questions, please contact CDC’s 24-hour Emergency Operations Center at 770-488-7100.

Clinical Presentation

The signs and symptoms of COVID-19 present at illness onset vary, but over the course of the disease, most persons with COVID-19 will experience the following:

  • Fever (83–99%)
  • Cough (59–82%)
  • Fatigue (44–70%)
  • Anorexia (40–84%)
  • Shortness of breath (31–40%)
  • Sputum production (28–33%)
  • Myalgias (11–35%)
COVID-19 Clinical Tips

Ten things healthcare providers involved in patient care should know related to:

  • Treatment and Prophylaxis
  • Symptoms and Diagnosis
  • Co-Infections
  • Severe Illness
Ending Home Isolation

Persons with COVID-19 who have symptoms and were directed to care for themselves at home may discontinue isolation under the following conditions:

  • At least 3 days (72 hours) have passed since recovery defined as resolution of fever without the use of fever-reducing medications and
  • Improvement in respiratory symptoms (e.g., cough, shortness of breath); and,
  • At least 10 days have passed since symptoms first appeared.