Considerations for Discharging People Under Investigation (PUIs) for Ebola Virus Disease (EVD)

Recommendations on this page apply to Ebola Disease and Marburg Virus Disease in healthcare settings. This page is currently being reviewed and terminology will be updated to reflect this broader application.

Healthcare providers evaluating a PUI should consider these criteria when deciding to discharge:

  1. In the clinical judgment of the medical team, the PUI’s illness no longer appears consistent with EVD.
  2. The PUI is afebrile off antipyretics for 24 hours, or there is an alternative explanation for fever.
  3. All symptoms that are compatible with EVD (for example, diarrhea or vomiting) have either resolved or can be accounted for by an alternative diagnosis.
  4. The PUI has no clinical laboratory results consistent with EVD, or those that could be consistent with EVD have been otherwise explained.
  5. The PUI is able to self-monitor (or to monitor a child, if the PUI is a child).
  6. There is a plan in place for the PUI to return for medical care if symptoms recur, which has been explained to the PUI, and the PUI understands what to do if symptoms recur.
  7. Local and state health departments have been engaged and concur.

Important information about RT-PCR testing for Ebola virus:

  • A negative RT-PCR test result for Ebola virus from a blood specimen collected less than 72 hours after onset of symptoms does not necessarily rule out Ebola virus infection.
    • If the patient is still symptomatic after 72 hours, the test should be repeated.
    • If the patient has recovered from the illness that brought them to medical attention, a repeat test is not required.
  • A negative RT-PCR test result for Ebola virus from a blood specimen collected more than 72 hours after symptom onset rules out Ebola virus infection.
  • Positive Ebola virus RT-PCR results are considered presumptive until confirmed by CDC.