2021 Guinea, N'Zérékoré Prefecture

On November 18, 2020, the DRC Ministry of Health and WHO declared the end of the Ebola outbreak in Equateur Province. Visit the Ebola Outbreak section for information on past Ebola outbreaks.


On February 14, 2021 the Ministry of Health (MOH) in Guinea announced that cases of Ebola virus disease (EVD) had been confirmed in N’Zérékoré Prefecture, a forested rural region in southeast Guinea. These are the first cases of EVD confirmed in Guinea since the 2014–2016 West Africa outbreak, the largest in history, was declared over.

Sequencing of samples from the outbreak was conducted and when compared to sequences from cases during the 2014-2016 West Africa outbreak, very few mutations were seen. Additionally, a mutation in a glycoprotein that is considered a marker for human adaptation of the virus, was identified in both sets of samples. While we cannot be one hundred percent certain, together these findings strongly support the conclusion that the outbreak is likely caused by a persistent source of infection (i.e. a survivor) and not a new introduction of the virus from the animal reservoir.

CDC is supporting response efforts by providing technical assistance to help contain the spread of the virus and bring the outbreak to an end.

Ebola Communication and Awareness Resources for healthcare workers and communities are available.

Map of Guinea EVD Outbreak, N'Zérékoré Prefecture, 2021