Administration of ERVEBO®

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Practice aseptic technique and standard precautions when preparing and administering ERVEBO® intramuscularly (IM).

Supplies required:

  • ERVEBO (supplied as 1-mL single dose vial containing ≥ 7.2 × 107 pfu)
  • Sterile syringe (e.g., 3-mL syringe)
  • Sterile needle for IM administration (e.g., 22-25 gauge, 1- to 1.5-inch length needle)

The vaccine will be shipped frozen at -80°C to -60°C (-112°F to -76°F). When stored/maintained at -80°C to -60°C (-112°F to -76°F), ERVEBO can be used by the indicated expiration date on the vaccine vial. If -80°C to -60°C (-112°F to -76°F) storage is not possible at the receipt site, thawed vaccine can be stored at 2°C to 8°C (35.6°F to 46.4°F) for up to 14 days.

Thaw the vaccine vial completely at room temperature until no visible ice is present (approximately 10 to 15 minutes). Do not thaw the vial in a refrigerator as the vaccine is sensitive to slow thawing. Gently invert vial several times. The vaccine is a colorless to slightly brownish-yellow liquid with no particulates visible. Do not use if particulate matter or discoloration exist. Use the vaccine immediately after thawing. If not used immediately, the vaccine may be stored for up to 14 days at 2ºC to 8ºC (35.6ºF to 46.4ºF) or for up to four hours at room temperature (up to 25°C; 77°F) protected from light. Do NOT re-freeze.

Using aseptic technique, withdraw a 1 mL dose using a syringe with a sterile injection needle and administer the vaccine by IM injection in the deltoid area of the non-dominant arm at a 90º angle into the muscle tissue using a needle long enough to ensure IM deposition of the vaccine.

  • Do not inject the vaccine intravascularly.
  • No data are available for administration via the subcutaneous or intradermal routes.

After administration of the vaccine, the used vial and syringe should be disposed of as biohazardous waste in accordance with the participating sites’ policy, as applicable. Used vials and syringes can be disposed of in normal biohazard containers, as the product does not contain Ebola virus.

Page last reviewed: November 17, 2021
Content source: Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of High-Consequence Pathogens and Pathology (DHCPP), Viral Special Pathogens Branch (VSPB)