Outcome Data from the Perinatal Hepatitis B Prevention Program

Outcome data on infants born to persons with hepatitis B virus infection are collected, analyzed, and reported by the CDC Perinatal Hepatitis B Prevention Program (PHBPP)(1), which funds 64 jurisdictions to identify pregnant persons infected with hepatitis B virus and to manage their infants to improve receipt of post-exposure prophylaxis (hepatitis B vaccine birth dose and hepatitis B immune globulin), hepatitis B vaccine series completion, and post-vaccination serologic testing.

Participating jurisdictions are the 50 US states, District of Columbia, 5 cities (Chicago, Houston, New York City, Philadelphia, and San Antonio), 5 territories (American Samoa, Guam, N. Mariana Islands, Puerto Rico, U.S. Virgin Islands), and 3 freely associated island nations (Federated States of Micronesia, Republic of the Marshall Islands, Republic of Palau). Data in this report are from the reporting period for the 2019 birth cohort, followed from January 1, 2019 through December 31, 2020 and only include infants whose care was managed by the program.

Follow-up time for infants vary in length depending on their date of birth. Because of differences in the states and jurisdictions participating, not all cases in infants identified as HBsAg positive within CDC PHBPP are reported to the CDC National Notifiable Diseases Surveillance System (NNDSS).