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Surveillance for Viral Hepatitis – United States, 2015

Entire report in a printable format [PDF – 2MB – 73 pages]

Contents

Summary of Trends in Viral Hepatitis – United States, 2015

Investigation of Healthcare-associated Outbreak Cases

Table 1.1 Hepatitis C Outbreaks by Setting ― United States, 2015

Hepatitis A virus

Index
PAGE
DESCRIPTION
Table 2.1 Reported cases of hepatitis A, nationally and by state or jurisdiction― United States, 2011-2015
Table 2.2 Select Clinical Characteristics of Hepatitis A Cases Reported in the United States, 2015
Table 2.3 Number and rate of hepatitis A-related deaths, by demographic characteristics and year — United States, 2011–2015
Figure 2.1 Reported number of hepatitis A — United States, 2000–2015
Figure 2.2 Incidence of hepatitis A, by age group — United States, 2000–2015
Figure 2.3 Incidence of hepatitis A, by sex — United States, 2000–2015
Figure 2.4 Incidence of hepatitis A, by race/ethnicity — United States, 2000–2015
Figure 2.5 Availability of information on risk exposures/behaviors associated with hepatitis A — United States, 2015
Figure 2.6a Hepatitis A reports, by risk exposure/behavior — United States, 2015
Figure 2.6b Hepatitis A reports, by risk exposure/behavior — United States, 2015
Map 2.1 2015 State Acute Hepatitis A Incidence Compared to Healthy People 2020 National Goal

Hepatitis A virus

Table 2.1. Reported cases of hepatitis A, nationally and by state or jurisdiction ― United States, 2011–2015

State
2011
2012
2013
2014
2015
No. Rate* No. Rate* No. Rate* No. Rate* No. Rate*
Alabama 8 0.2 19 0.4 10 0.2 15 0.3 23 0.5
Alaska 4 0.6 1 0.1 1 0.1 1 0.1 4 0.5
Arizona 77 1.2 93 1.4 66 1.0 29 0.4 54 0.8
Arkansas 3 0.1 8 0.3 9 0.3 2 0.1 10 0.3
California 186 0.5 209 0.5 255 0.7 142 0.4 179 0.5
Colorado 21 0.4 28 0.5 51 1.0 23 0.4 25 0.5
Connecticut 18 0.5 23 0.6 19 0.5 23 0.6 9 0.3
Delaware 2 0.2 9 1.0 4 0.4 1 0.1 2 0.2
District of Columbia U U U U U U U U U U
Florida 87 0.5 87 0.5 115 0.6 90 0.5 108 0.5
Georgia 27 0.3 46 0.5 36 0.4 24 0.2 30 0.3
Hawaii 8 0.6 5 0.4 16 1.1 5 0.4 6 0.4
Idaho 6 0.4 11 0.7 8 0.5 7 0.4 9 0.5
Illinois 73 0.6 67 0.5 79 0.6 82 0.6 57 0.4
Indiana 24 0.4 11 0.2 32 0.5 20 0.3 19 0.3
Iowa 8 0.3 7 0.2 17 0.6 12 0.4 16 0.5
Kansas 4 0.1 15 0.5 11 0.4 7 0.2 7 0.2
Kentucky 10 0.2 25 0.6 24 0.5 19 0.4 16 0.4
Louisiana 5 0.1 7 0.2 14 0.3 5 0.1 5 0.1
Maine 6 0.5 9 0.7 10 0.8 8 0.6 8 0.6
Maryland 26 0.4 28 0.5 29 0.5 27 0.5 19 0.3
Massachusetts 39 0.6 40 0.6 43 0.6 43 0.6 34 0.5
Michigan 70 0.7 100 1.0 83 0.8 45 0.5 51 0.5
Minnesota 27 0.5 29 0.5 32 0.6 19 0.3 21 0.4
Mississippi 7 0.2 11 0.4 5 0.2 3 0.1 2 0.1
Missouri 13 0.2 20 0.3 8 0.1 20 0.3 9 0.1
Montana 3 0.3 6 0.6 6 0.6 5 0.5 2 0.2
Nebraska 5 0.3 16 0.9 13 0.7 9 0.5 6 0.3
Nevada 5 0.2 10 0.4 19 0.7 5 0.2 11 0.4
New Hampshire 0 0.0 6 0.5 9 0.7 5 0.4 2 0.2
New Jersey 79 0.9 60 0.7 68 0.8 59 0.7 59 0.7
New Mexico 7 0.3 10 0.5 20 1.0 8 0.4 6 0.3
New York 113 0.6 111 0.6 167 0.8 84 0.4 123 0.6
North Carolina 31 0.3 34 0.3 46 0.5 38 0.4 45 0.4
North Dakota 0 0.0 2 0.3 9 1.2 9 1.2 5 0.7
Ohio 39 0.3 36 0.3 59 0.5 32 0.3 36 0.3
Oklahoma 11 0.3 12 0.3 14 0.4 17 0.4 11 0.3
Oregon 11 0.3 9 0.2 29 0.7 13 0.3 28 0.7
Pennsylvania 60 0.5 62 0.5 53 0.4 48 0.4 43 0.3
Rhode Island 8 0.8 3 0.3 4 0.4 8 0.8 4 0.4
South Carolina 11 0.2 6 0.1 14 0.3 6 0.1 16 0.3
South Dakota 2 0.2 0 0.0 4 0.5 3 0.4 2 0.2
Tennessee 23 0.4 23 0.4 20 0.3 12 0.2 14 0.2
Texas 138 0.5 134 0.5 109 0.4 124 0.5 147 0.5
Utah 8 0.3 4 0.1 12 0.4 8 0.3 8 0.3
Vermont 6 1.0 2 0.3 7 1.1 1 0.2 3 0.5
Virginia 30 0.4 49 0.6 36 0.4 27 0.3 50 0.6
Washington 31 0.5 29 0.4 45 0.6 26 0.4 26 0.4
West Virginia 8 0.4 8 0.4 4 0.2 12 0.6 8 0.4
Wisconsin 8 0.1 21 0.4 37 0.6 7 0.1 9 0.2
Wyoming 2 0.4 1 0.2 0 0.0 1 0.2 3 0.5
U.S. 1398 0.4 1562 0.5 1781 0.6 1239 0.4 1390 0.4

Source: CDC, National Notifiable Diseases Surveillance System.
*Rate per 100,000 population.
U=No data available for reporting.

Table 2.2. Select Clinical Characteristics of Hepatitis A Cases* Reported in the United States, 2015

Clinical characteristic
Availability of valid data† for clinical characteristic
Cases with clinical characteristic§
No.
%
No.
%
Jaundice
865
62.2
541
62.5
Hospitalized for hepatitis A
870
62.6
411
47.2
Died from hepatitis A
801
57.6
8
1

Source: CDC, National Notifiable Diseases Surveillance System.
*A total of 1,390 hepatitis A cases were reported during 2015.
†Case reports for which questions regarding clinical characteristics were answered with “yes” or “no.” Reports with any other response were excluded.
§Numbers and percentages represent only those case reports for which data regarding clinical characteristics were available; numbers likely are underestimates.

Table 2.3. Number and rate* of hepatitis A-related deaths, by demographic characteristics and year — United States, 2011–2015

Demographic characteristic
2011
2012§
2013
2014
2015
No. Rate No. Rate No. Rate No. Rate No. Rate
  Age Group
(years)
0–34 0 0.00 2 0.00 2 0.00 0 0.00 1 0.00
35–44 1 0.00 5 0.01 2 0.00 4 0.01 4 0.01
45–54 11 0.02 12 0.03 13 0.03 7 0.02 6 0.01
55–64 16 0.04 23 0.06 30 0.08 28 0.07 19 0.05
65–74 12 0.05 17 0.07 19 0.08 19 0.07 16 0.06
≥75 29 0.15 18 0.09 14 0.07 18 0.09 21 0.10
Race/
ethnicity§
White NH (non-Hispanic) 44 0.02 51 0.02 63 0.02 51 0.02 45 0.02
Black NH 10 0.03 8 0.02 6 0.01 11 0.03 7 0.02
Hispanic 6 0.02 8 0.02 8 0.02 10 0.02 10 0.03
Asian/Pacific Islander 8 0.06 7 0.05 3 0.02 2 0.01 4 0.02
American Indian/Alaska Native 1 0.04 2 0.08 0 0.00 2 0.10 1 0.04
Sex Male 37 0.02 46 0.03 50 0.03 42 0.02 38 0.02
Female 32 0.02 31 0.02 30 0.01 34 0.02 29 0.02
Overall  69 0.02 77 0.02 80 0.02 76 0.02 67 0.02

Source: CDC, National Vital Statistics System.
*Rates for race, sex, and overall total are age-adjusted per 100,000 U.S. standard population in 2000.
†Cause of death is defined as the underlying cause of death or one of the multiple causes of death and is based on the International Classification of Diseases, 10th Revision (ICD-10) codes B15 (hepatitis A).
§One death in 2012 is not represented under the race/ethnicity category due to missing data.

Figure 2.1. Reported number of hepatitis A cases – United States, 2000-2015
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Figure 2.2. Incidence of hepatitis A, by age group – United States, 2000-2015
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Figure 2.3. Incidence of hepatitis A, by sex — United States, 2000–2015
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Figure 2.4. Incidence of hepatitis A, by race/ethnicity — United States, 2000–2015
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Figure 2.5. Availability of information on risk exposures/behaviors associated with hepatitis A — United States, 2015
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Figure 2.6a. Hepatitis A reports, by risk exposure/behavior – United States, 2015
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Figure 2.6b. Hepatitis A reports, by risk exposure/behavior – United States, 2015
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Map 2.1. 2015 State Acute Hepatitis A Incidence Compared to Healthy People 2020 National Goal
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Hepatitis B virus

Index
PAGE
DESCRIPTION
Table 3.1 Reported cases of acute hepatitis B, nationally and by state or jurisdiction ― United States, 2011–2015
Table 3.2 Select Clinical Characteristics of Acute Hepatitis B Cases Reported in the United States, 2015
Table 3.3 Number of newly reported case reports of confirmed chronic hepatitis B submitted by states or jurisdictions, 2015
Table 3.4 Reported cases of chronic hepatitis B, by demographic characteristics and laboratory tests — Enhanced Viral Hepatitis Surveillance Sites, 2015
Table 3.5 Number and rate of hepatitis B-related deaths, by demographic characteristics and year— United States, 2011–2015
Table 3.6 Number of newly reported case reports of perinatal hepatitis B submitted by states and jurisdictions, 2015
Figure 3.1 Reported number of acute hepatitis B — United States, 2000–2015
Figure 3.2 Incidence of acute hepatitis B, by age group — United States, 2000–2015
Figure 3.3 Incidence of acute hepatitis B, by sex — United States, 2000–2015
Figure 3.4 Incidence of acute hepatitis B, by race/ethnicity — United States, 2000–2015
Figure 3.5 Availability information on risk exposures/behaviors associated with acute hepatitis B — United States, 2015
Figure 3.6a Acute hepatitis B reports, by risk exposure/behavior — United States, 2015
Figure 3.6b Acute hepatitis B reports, by risk exposure/behavior — United States, 2015
Map 3.1 2015 State Acute Hepatitis B Incidence Compared to Healthy People 2020 National Goal

Hepatitis B virus

Table 3.1. Reported cases of acute hepatitis B, nationally and by state or jurisdiction ― United States, 2011–2015

State
2011
2012
2013
2014
2015
No. Rate* No. Rate* No. Rate* No. Rate* No. Rate*
Alabama 119 2.5 79 1.6 90 1.9 117 2.4 101 2.1
Alaska 3 0.4 1 0.1 1 0.1 3 0.4 3 0.4
Arizona 14 0.2 14 0.2 28 0.4 31 0.5 25 0.4
Arkansas 57 1.9 74 2.5 50 1.7 28 0.9 36 1.2
California 157 0.4 136 0.4 138 0.4 110 0.3 160 0.4
Colorado 23 0.4 24 0.5 24 0.5 29 0.5 28 0.5
Connecticut 19 0.5 15 0.4 8 0.2 9 0.3 6 0.2
Delaware 13 1.4 11 1.2 14 1.5 8 0.9 8 0.8
District of Columbia U U U U U U U U U U
Florida 213 1.1 247 1.3 323 1.7 313 1.6 432 2.1
Georgia 142 1.4 109 1.1 104 1.0 103 1.0 119 1.2
Hawaii 6 0.4 5 0.4 4 0.3 6 0.4 14 1.0
Idaho 2 0.1 5 0.3 13 0.8 6 0.4 8 0.5
Illinois 85 0.7 86 0.7 94 0.7 58 0.5 55 0.4
Indiana 70 1.1 90 1.4 101 1.5 126 1.9 133 2.0
Iowa 15 0.5 13 0.4 11 0.4 9 0.3 16 0.5
Kansas 15 0.5 9 0.3 11 0.4 11 0.4 19 0.7
Kentucky 151 3.5 180 4.1 214 4.9 164 3.7 162 3.7
Louisiana 62 1.4 44 1.0 82 1.8 87 1.9 87 1.9
Maine 8 0.6 9 0.7 11 0.8 12 0.9 9 0.7
Maryland 62 1.1 52 0.9 43 0.7 40 0.7 40 0.7
Massachusetts 67 1.0 75 1.1 71 1.1 30 0.4 25 0.4
Michigan 91 0.9 81 0.8 53 0.5 50 0.5 56 0.6
Minnesota 20 0.4 17 0.3 19 0.4 16 0.3 19 0.3
Mississippi 57 1.9 78 2.6 55 1.8 48 1.6 50 1.7
Missouri 60 1.0 48 0.8 61 1.0 31 0.5 35 0.6
Montana 0 0.0 2 0.2 4 0.4 0 0.0 4 0.4
Nebraska 12 0.7 10 0.5 9 0.5 8 0.4 3 0.2
Nevada 29 1.1 28 1.0 29 1.0 21 0.7 25 0.9
New Hampshire 3 0.2 4 0.3 2 0.2 4 0.3 0 0.0
New Jersey 73 0.8 70 0.8 65 0.7 77 0.9 85 0.9
New Mexico 10 0.5 3 0.1 3 0.1 2 0.1 2 0.1
New York 134 0.7 113 0.6 117 0.6 95 0.5 80 0.4
North Carolina 109 1.1 73 0.7 75 0.8 100 1.0 165 1.6
North Dakota 0 0.0 0 0.0 0 0.0 0 0.0 2 0.3
Ohio 90 0.8 178 1.5 225 1.9 171 1.5 409 3.5
Oklahoma 100 2.6 79 2.1 40 1.0 57 1.5 37 0.9
Oregon 32 0.8 25 0.6 32 0.8 32 0.8 24 0.6
Pennsylvania 84 0.7 63 0.5 43 0.3 68 0.5 61 0.5
Rhode Island U U U U U U U U U U
South Carolina 39 0.8 37 0.8 58 1.2 37 0.8 30 0.6
South Dakota 2 0.2 2 0.2 5 0.6 3 0.4 2 0.2
Tennessee 192 3.0 240 3.7 262 4.0 232 3.5 243 3.7
Texas 204 0.8 170 0.7 142 0.5 122 0.5 159 0.6
Utah 10 0.4 13 0.5 5 0.2 11 0.4 10 0.3
Vermont 0 0.0 2 0.3 2 0.3 4 0.6 3 0.5
Virginia 84 1.0 84 1.0 72 0.9 61 0.7 69 0.8
Washington 35 0.5 34 0.5 33 0.5 44 0.6 34 0.5
West Virginia 113 6.1 141 7.6 195 10.5 186 10.1 272 14.7
Wisconsin 17 0.3 22 0.4 9 0.2 11 0.2 5 0.1
Wyoming 0 0.0 0 0.0 U U U U U U
Total 2903 0.9 2895 0.9 3050 1.0 2791 0.9 3370 1.1

Source: CDC, National Notifiable Diseases Surveillance System.
*Rate per 100,000 population.
U=No data available for reporting.

Table 3.2. Select Clinical Characteristics of Acute Hepatitis B Cases* Reported in the United States, 2015

Clinical characteristic
Availability of valid data† for clinical characteristic
Cases with clinical characteristic§
No.
%
No.
%
Jaundice
2,526 75.0 1,891 74.9
Hospitalized for hepatitis B
2,515 74.6 1,502 59.7
Died from hepatitis B
2,311 68.6 20 0.9

Source: CDC, National Notifiable Diseases Surveillance System.
*A total of 3,370 hepatitis B cases were reported during 2015.
†Case reports for which questions regarding clinical characteristics were answered with “yes” or “no.” Reports with any other response were excluded.
§Numbers and percentages represent only those case reports for which data regarding clinical characteristics were available; numbers likely are underestimates.

Table 3.3. Number of newly reported case* reports of confirmed chronic hepatitis B submitted by states or jurisdictions, 2015

State/Jurisdiction No. chronic hepatitis B
case reports submitted
Alabama N
Alaska N
Arizona 133
Arkansas N
California 1,008
Colorado 163
Connecticut 38
Delaware 122
District of Columbia U
Florida 1,423
Georgia 1,867
Hawaii N
Idaho 51
Illinois 440
Indiana 68
Iowa 39
Kansas 130
Kentucky 16
Louisiana 201
Maine 51
Maryland 566
Massachusetts 284
Michigan 350
Minnesota 186
Mississippi N
Missouri 521
Montana 31
Nebraska 93
Nevada N
New Hampshire N
New Jersey 273
New Mexico 41
New York 2,315
North Carolina 507
North Dakota 53
Ohio 890
Oklahoma 84
Oregon 138
Pennsylvania 857
Rhode Island U
South Carolina 156
South Dakota 23
Tennessee 253
Texas N
Utah 64
Vermont 39
Virginia 556
Washington 119
West Virginia 225
Wisconsin N
Wyoming 42
Total 14,416

Source: CDC, National Notifiable Diseases Surveillance System.
*For case-definition, see https://wwwn.cdc.gov/nndss/conditions/hepatitis-b-chronic/case-definition/2012/
Reports may not reflect unique cases.
§ Cases reported by California through NNDSS were all from San Francisco County.  The number of cases in this table and table 3.4 differ because NNDSS and CDC’s Secure Access Management System (SAMS)
N= Not Reportable, chronic hepatitis B infection is not reportable in the listed state.
U=No data available for reporting

Table 3.4. Reported cases of chronic hepatitis B, by demographic characteristics and laboratory tests — Enhanced Viral Hepatitis Surveillance Sites, 2015

Category FL*
No. %
MA
No. %
MI
No. %
NYS†
No. %
Phil
No. %
SF
No. %
WA
No. %
Total
No. %
Sex
Female 641 222 167 334 47 501 67 1979
44.5% 47.0% 46.4% 43.1% 39.5% 47.0% 44.1% 45.1%
Male 798 250 193 440 71 566 83 2401
55.4% 53.0% 53.6% 56.8% 59.7% 53.0% 54.6% 54.7%
Unknown /missing 2 0 0 1 1 0 2 6
0.10% 0.00% 0.00% 0.10% 0.80% 0.00% 1.30% 0.10%
Race/Ethnicity
American Indian/ Alaska Native, NH¶ 0 8 6 1 1 0 0 16
0.0% 1.7% 1.7% 0.1% 0.8% 0.0% 0.0% 0.4%
Asian/Pacific Islander, NH 81 159 90 265 45 562 22 1224
5.6% 33.7% 25.0% 34.2% 37.8% 52.7% 14.5% 27.9%
Black,  NH 187 87 46 92 23 13 12 460
13.0% 18.4% 12.8% 11.9% 19.3% 1.2% 7.9% 10.5%
White,   NH 290 48 108 86 12 26 13 583
20.1% 10.2% 30.0% 11.1% 10.1% 2.4% 8.6% 13.3%
Hispanic 90 15 5 40 5 20 4 179
6.2% 3.2% 1.4% 5.2% 4.2% 1.9% 2.6% 4.1%
Other,  NH 47 28 22 33 4 10 5 149
3.3% 5.9% 6.1% 4.3% 3.4% 0.9% 4.2% 3.4%
Unknown /missing 746 135 83 258 29 436 96 1783
51.8% 28.6% 23.1% 33.3% 24.4% 40.9% 63.2% 40.7%
Age group, years
0-14 9 6 8 4 1 7 3 38
0.6% 1.3% 2.2% 0.5% 0.8% 0.7% 2.0% 0.9%
15-24 67 33 26 63 9 43 15 256
4.6% 7.0% 7.2% 8.1% 7.6% 4.0% 9.9% 5.8%
25-39 428 209 116 292 41 339 52 1,477
29.7% 44.3% 32.2% 37.7% 34.5% 31.8% 34.2% 33.7%
40-54 479 126 114 235 43 378 47 1,422
33.2% 26.7% 31.7% 30.3% 36.1% 35.4% 30.9% 32.4%
55+ 458 98 96 181 25 303 35 1,196
31.8% 20.8% 26.7% 23.4% 21.0% 28.4% 23.0% 27.3%
Unknown /missing 0 0 0 0 0 0 0 0
0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%
Place of Birth
United States 25 85 5 51 14 180
5.3% 23.6% 0.6% 42.9% 1.3% 4.1%
Outside United States 180 128 24 62 136 530
38.1% 35.6% 3.1% 52.1% 12.7% 12.1%
Unknown /missing 1,441 267 147 746 6 917 152 3,676
100.00% 56.6% 40.8% 96.3% 5.0% 85.9% 100.0% 83.8%
Hepatitis B laboratory testing**
HBV surface antigen + 1,301 398 270 690 97 943 90 3,789
90.3% 84.3% 75.0% 89.0% 81.5% 88.4% 59.2% 86.4%
[IgM anti-HBc] – 986 84 63 236 0 0 0 1,369
68.4% 17.8% 17.5% 30.5% 0.0% 0.0% 0.0% 31.2%
HBV “e” antigen + 193 85 12 136 35 106 20 587
13.4% 18.0% 3.3% 17.5% 29.4% 9.9% 13.2% 13.4%
HBV NAT + 652 382 13 338 99 941 24 2,449
45.2% 80.9% 3.6% 43.6% 83.2% 88.2% 15.8% 55.8%
Total no. cases 1,441 472 360 775 119 1,067 152 4,386
2015 Estimated population total†† 20,271,272 6,794,422 9,922,576 11,245,386 1,567,442 864,816 7,170,351 57,836,265
Rate per 100,000 population 7.1 6.9 3.6 6.9 7.6 123.4 2.1 7.6

Source: CDC, Enhanced Viral Hepatitis Surveillance Sites.
Abbreviations: FL, Florida, MA, Massachusetts; MI, Michigan; NYS, New York State; Phil, Philadelphia; SF, San Francisco; WA, Washington State
Percentages may not sum to 100% due to rounding.
* Florida DOH only reported cases from the following 10 counties: Alachua, Broward, Hillsborough, Miami-Dade, Orange, Palm Beach, Pinellas, Polk, Sarasota, and Seminole
†New York City was not included in the case count for New York State, therefore cases and population estimates from New York excluded those who resided in New York City
§The denominator used to calculate proportions was the total number of cases reported for each site.
¶NH: Non-Hispanic
**Cases can be reported with more than one laboratory test result.
††Population estimates for the United States: https://www.census.gov/quickfacts/table/PST045216/00
HBV: Hepatitis B Virus; IgM anti-HBc (Anti-Hepatitis B core IgM); NAT: HBV nucleic acid testing.

Table 3.5. Number and rate* of hepatitis B-related deaths, by demographic characteristics and year – United States, 2011-2015

Demographic
characteristic
2011
2012
2013
2014
2015
No. Rate No. Rate No. Rate No. Rate No. Rate
  Age Group
(years)§
0–34 41 0.03 38 0.03 40 0.03 35 0.02 31 0.02
35–44 143 0.35 123 0.30 146 0.36 126 0.31 120 .3
45–54 421 0.94 428 0.97 389 0.89 384 0.88 332 0.77
55–64 645 1.69 639 1.66 704 1.79 684 1.71 611 1.49
65–74 285 1.27 314 1.31 343 1.36 358 1.36 384 1.39
≥75 269 1.42 229 1.20 251 1.29 256 1.29 236 1.17
Race / ethnicity White NH (non-Hispanic) 832 0.32 818 0.31 868 0.33 853 0.32 809 0.3
Black NH 373 0.98 322 0.81 384 0.98 330 0.80 320 0.78
Hispanic 161 0.48 139 0.39 149 0.39 155 0.38 134 0.32
Asian / Pacific Islander 422 2.72 469 2.93 451 2.64 478 2.71 420 2.24
American Indian / Alaska Native 9 0.39 18 0.74 14 0.55 11 0.43 16 0.58
Sex Male 1,321 0.80 1,272 0.75 1,375 0.79 1,307 0.74 1277 0.72
Female 483 0.26 499 0.27 498 0.26 536 0.27 438 0.22
Overall  1,804 0.52 1,771 0.50 1,873 0.52 1,843 0.50 1,715  0.45 

Source: CDC, National Vital Statistics System.
*Rates for race, sex, and overall total are age-adjusted per 100,000 U.S. standard population in 2000.
†Cause of death is defined as the underlying cause of death or one of the multiple causes of death and is based on the International Classification of Diseases, 10th Revision (ICD-10) codes B16, B17.0, B18.0, B18.1 (hepatitis B).
§ One death in 2015 is not represented under the age group category due to missing data
¶ Seven deaths in 2011, five deaths in 2012, seven deaths in 2013, 16 deaths in 2014, and 16 deaths in 2015 are not represented under the race/ethnicity category due to missing data.

Table 3.6. Number of newly reported case* reports of perinatal hepatitis B§ submitted by states and jurisdictions, 2015

State/Jurisdiction No. Perinatal hepatitis B
case reports† submitted
Alabama 1
California 11
Colorado 1
Connecticut 1
Georgia 2
Hawaii 1
Massachusetts 1
Minnesota 3
Nebraska 1
Nevada 1
New York 4
North Carolina 1
Oregon 2
Texas 1
Virginia 1
Washington 1
West Virginia 2
Wisconsin 2
Total 37

Source: CDC, National Notifiable Diseases Surveillance System.
*For case-definition, see https://wwwn.cdc.gov/nndss/conditions/hepatitis-b-perinatal-virus-infection/case-definition/1995/
†Reports may not reflect unique cases.
§ Perinatal hepatitis B is not reportable disease in ALL jurisdictions

Figure 3.1. Reported number of acute hepatitis B cases — United States, 2000–2015
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Figure 3.2. Incidence of acute hepatitis B, by age group — United States, 2000–2015
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Figure 3.3. Incidence of acute hepatitis B, by sex — United States, 2000–2015
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Figure 3.4. Incidence of acute hepatitis B, by race/ethnicity — United States, 2000–2015
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Figure 3.5. Availability of information on risk exposures/behaviors associated with acute hepatitis B — United States, 2015
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Figure 3.6a. Acute hepatitis B reports, by risk exposure/behavior — United States, 2015
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Figure 3.6b. Acute hepatitis B reports, by risk exposure/behavior — United States, 2015
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Map 3.1. 2015 State Acute Hepatitis B Incidence Compared to Healthy People 2020 National Goal
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All seven figure slides in PowerPoint [PPT – 374 KB]

Hepatitis C virus

Index
PAGE
DESCRIPTION
Table 4.1 Reported cases of acute hepatitis C, nationally and by state and jurisdiction ―United States, 2011-2015
Table 4.2 Select Clinical Characteristics of Acute Hepatitis C Cases  Reported in the United States, 2015
Table 4.3 Number of newly reported case reports of confirmed past or present Hepatitis C submitted by states and jurisdictions, 2015
Table 4.4 Reported cases of past or present hepatitis C, by demographic characteristics and laboratory tests — Enhanced Viral Hepatitis Surveillance Sites, 2015
Table 4.5 Number and rate of hepatitis C-related deaths†, by demographic characteristic and year — United States, 2011-2015
Figure 4.1 Reported number of acute hepatitis C — United States, 2000–2015
Figure 4.2 Incidence of acute hepatitis C, by age group — United States, 2000–2015
Figure 4.3 Incidence of acute hepatitis C, by sex — United States, 2000–2015
Figure 4.4 Incidence of acute hepatitis C, by race/ethnicity — United States, 2000–2015
Figure 4.5 Availability of information on risk exposures/behaviors associated with acute hepatitis C — United States, 2015
Figure 4.6a Acute hepatitis C reports, by risk exposure/behavior — United States, 2015
Figure 4.6b Acute hepatitis C reports, by risk exposure/behavior — United States, 2015
Map 4.1 2015 State Acute Hepatitis C Incidence Compared to Healthy People 2020 National Goal

Hepatitis C virus

Table 4.1. Reported cases of acute hepatitis C, nationally and by state and jurisdiction ―United States, 2011-2015

State
2011
2012
2013
2014
2015
No. Rate* No. Rate* No. Rate* No. Rate* No. Rate*
Alabama 23 0.5 24 0.5 30 0.6 35 0.7 70 1.4
Alaska U U U U U U U U U U
Arizona U U U U U U U U U U
Arkansas 0 0.0 5 0.2 30 1.0 13 0.4 2 0.1
California 48 0.1 63 0.2 72 0.2 73 0.2 59 0.2
Colorado 28 0.5 42 0.8 21 0.4 33 0.6 40 0.7
Connecticut 47 1.3 34 0.9 U U U U U U
Delaware 3 0.3 U U U U U U 4 0.4
District of Columbia U U U U U U U U U U
Florida 64 0.3 107 0.6 134 0.7 93 0.5 126 0.6
Georgia 53 0.5 82 0.8 48 0.5 57 0.6 84 0.8
Hawaii U U U U U U U U U U
Idaho 12 0.8 11 0.7 14 0.9 6 0.4 4 0.2
Illinois 6 0.0 26 0.2 37 0.3 27 0.2 31 0.2
Indiana 84 1.3 110 1.7 175 2.7 122 1.8 138 2.1
Iowa 0 0.0 3 0.1 U U U U U U
Kansas 8 0.3 16 0.6 17 0.6 28 1.0 22 0.8
Kentucky 142 3.2 178 4.1 226 5.1 176 4.0 119 2.7
Louisiana 7 0.2 11 0.2 19 0.4 22 0.5 24 0.5
Maine 12 0.9 8 0.6 8 0.6 31 2.3 30 2.3
Maryland 35 0.6 39 0.7 53 0.9 42 0.7 38 0.6
Massachusetts 23 0.3 37 0.6 174 2.6 228 3.4 249 3.7
Michigan 32 0.3 76 0.8 74 0.7 78 0.8 83 0.8
Minnesota 17 0.3 32 0.6 47 0.9 40 0.7 37 0.7
Mississippi U U U U U U U U U U
Missouri 8 0.1 4 0.1 6 0.1 6 0.1 8 0.1
Montana 9 0.9 9 0.9 16 1.6 13 1.3 15 1.5
Nebraska 2 0.1 3 0.2 2 0.1 2 0.1 8 0.4
Nevada 10 0.4 12 0.4 9 0.3 6 0.2 12 0.4
New Hampshire U U U U U U U U U U
New Jersey 53 0.6 71 0.8 106 1.2 113 1.3 130 1.5
New Mexico 14 0.7 21 1.0 12 0.6 16 0.8 40 1.9
New York 52 0.3 93 0.5 131 0.7 126 0.6 121 0.6
North Carolina 60 0.6 63 0.6 79 0.8 111 1.1 144 1.4
North Dakota 0 0.0 0 0.0 4 0.6 0 0.0 0 0.0
Ohio 6 0.1 7 0.1 116 1.0 105 0.9 122 1.1
Oklahoma 53 1.4 80 2.1 40 1.0 45 1.2 35 0.9
Oregon 20 0.5 37 0.9 14 0.4 15 0.4 13 0.3
Pennsylvania 35 0.3 66 0.5 81 0.6 69 0.5 129 1.0
Rhode Island U U U U U U U U U U
South Carolina 1 0.0 1 0.0 0 0.0 4 0.1 5 0.1
South Dakota U U U U U U U U U U
Tennessee 83 1.3 129 2.0 98 1.5 123 1.9 173 2.6
Texas 37 0.1 44 0.2 28 0.1 47 0.2 48 0.2
Utah 10 0.4 17 0.6 11 0.4 38 1.3 30 1.0
Vermont 6 1.0 6 1.0 3 0.5 4 0.6 1 0.2
Virginia 25 0.3 76 0.9 41 0.5 54 0.6 52 0.6
Washington 41 0.6 54 0.8 63 0.9 82 1.2 63 0.9
West Virginia 46 2.5 55 3.0 58 3.1 62 3.4 63 3.4
Wisconsin 15 0.3 26 0.5 40 0.7 49 0.9 64 1.1
Wyoming 2 0.4 U U U U U U U U
Total 1232 0.4 1778 0.6 2138 0.7 2194 0.7 2436 0.8

Source: CDC, National Notifiable Diseases Surveillance System.
*Rate per 100,000 population.
U=No data available for reporting.

Table 4.2. Select Clinical Characteristics of Acute Hepatitis C Cases*  Reported in the United States, 2015

Clinical characteristic
Availability of valid data† for clinical characteristic
Cases with clinical characteristic§
No.
%
No.
%
Jaundice
1,696 69.6 927 54.7
Hospitalized for hepatitis C
1,552 63.7 822 53.0
Died from hepatitis C
1,318 54.1 6 0.5

Source: CDC, National Notifiable Diseases Surveillance System.
*A total of 2,436 acute hepatitis C cases were reported during 2015.
Case reports for which questions regarding clinical characteristics were answered with “yes” or “no.” Reports with any other response were excluded.
§Numbers and percentages represent only those case reports for which data regarding clinical characteristics were available; numbers likely are underestimates.

Table 4.3. Number of newly reported case* reports of confirmed past or present Hepatitis C submitted by states and jurisdictions, 2015

State/Jurisdiction No. past/present hepatitis C
case reports submitted
Alabama N
Alaska 1,604
Arizona U
Arkansas 1
California§ 1,182
Colorado 3,561
Connecticut 3,291
Delaware 31
District of Columbia U
Florida 22,793
Georgia 7,175
Hawaii U
Idaho 1,017
Illinois 8,696
Indiana U
Iowa 20
Kansas 1,697
Kentucky 4
Louisiana 2,478
Maine 1,486
Maryland 7,425
Massachusetts 5,482
Michigan 6,808
Minnesota 2,015
Mississippi N
Missouri 7,800
Montana 1,354
Nebraska 893
Nevada N
New Hampshire N
New Jersey 7,928
New Mexico 3,680
New York 15,058
North Carolina N
North Dakota 794
Ohio 19,165
Oklahoma 590
Oregon 5,472
Pennsylvania 11,988
Rhode Island U
South Carolina 4,515
South Dakota 567
Tennessee 2,251
Texas N
Utah 1,578
Vermont 808
Virginia 8,138
Washington 5,712
West Virginia 6,339
Wisconsin 3
Wyoming 472
Total 181,871

Source: CDC, National Notifiable Diseases Surveillance System
*For case-definition, see https://wwwn.cdc.gov/nndss/conditions/hepatitis-c-chronic/case-definition/2012/.
Reports may not reflect unique cases.
§Cases reported by California through NNDSS were all from San Francisco County. Differences in the number of cases in this table and table 4.4 are because NNDSS and CDC’s Secure Access Management System (SAMS) have different data close-out dates by which all annual data must be submitted.
N=Not Reportable, past/present hepatitis C is not reportable in the listed state.
U= No data available for reporting

Table 4.4. Reported cases of past or present hepatitis C, by demographic characteristics and laboratory tests – Enhanced Viral Hepatitis Surveillance Sites, 2015

Category FL*
No. %§
MA
No. %
MI
No. %
NYS
No. %
Phil
No. %
SF
No. %
WA
No. %
Total
No. %
Sex
Female 10,271 2,334 2,666 3,151 560 431 2,236 21,649
40.2% 39.9% 37.9% 37.7% 33.5% 27.2% 37.6% 38.6%
Male 15,206 3,500 4,352 5,131 1,097 1,152 3,639 34,077
59.5% 59.8% 61.9% 61.4% 65.7% 72.7% 61.1% 60.8%
Unknown /missing 98 21 14 71 14 2 80 303
0.4% 0.4% 0.2% 0.8% 0.8% 0.1% 1.3% 0.5%
 Race/ethnicity
American Indian/
Alaska Native, NH
29 14 58 43 2 5 0 151
0.1% 0.2% 0.8% 0.5% 0.1% 0.3% 0.0% 0.3%
Asian/Pacific Islander,  NH 54 97 44 97 13 57 39 404
0.2% 1.7% 0.6% 1.2% 0.8% 3.6% 0.7% 0.7%
Black, NH 957 243 1,184 682 153 234 164 3,617
3.7% 4.2% 16.8% 8.2% 9.2% 14.8% 2.8% 6.5%
White, NH 7,519 2,566 3,346 4,067 185 580 1,611 19,874
29.4% 43.8% 47.6% 48.7% 11.1% 36.6% 27.1% 35.5%
Hispanic 1,135 330 112 541 89 116 135 2,458
4.4% 5.6% 1.6% 6.5% 5.3% 7.3% 2.3% 4.4%
Other,  NH 271 210 86 132 12 0 42 753
1.1% 3.6% 1.2% 1.6% 0.7% 0.0% 0.7% 1.3%
Unknown /missing 15,610 2,395 2,202 2,791 1,217 593 3,964 28,772
61.0% 40.9% 31.3% 33.4% 72.8% 37.4% 66.6% 51.0%
Age group, years
0-14 67 25 16 15 10 1 18 152
0.3% 0.4% 0.2% 0.2% 0.6% 0.1% 0.3% 0.3%
15-24 2,343 794 537 1,064 58 35 427 5,258
9.2% 13.6% 7.6% 12.7% 3.5% 2.2% 7.2% 9.4%
25-39 7,071 2,197 1,795 2,720 362 295 1,473 15,913
27.6% 37.5% 25.5% 32.6% 21.7% 18.6% 24.7% 28.4%
40-54 6,314 1,285 1,454 1,787 466 452 1,590 13,348
24.7% 21.9% 20.7% 21.4% 27.9% 28.5% 26.7% 23.7%
55+ 9,766 1,546 3,226 2,752 773 792 2,438 21,293
38.2% 26.4% 45.9% 32.9% 46.3% 50.0% 40.9% 38.0%
Unknown /missing 14 8 4 15 2 10 9 62
0.1% 0.1% 0.1% 0.2% 0.1% 0.6% 0.2% 0.1%
 Hepatitis C laboratory testing**
Anti-HCV+ 15,975 4,613 4,861 5,715 987 977 3,862 36,990
62.5% 78.8% 69.1% 68.4% 59.1% 61.6% 64.9% 66.0%
HCV RNA+ 15,226 4,505 2,318 5,862 1,639 1,179 2,656 33,385
59.5% 76.9% 33.0% 70.2% 98.1% 74.4% 44.6% 59.6%
Total no. cases   25,575 5,855 7,032 8,353 1,671 1,585 5,955 56,026
2015 Estimated population total†† 20,271,272 6,794,422 9,922,576 11,245,386 1,567,442 864,816 7,170,351 57,836,265
Rate per 100,000 population 126.2 86.2 70.9 74.3 106.6 183.3 83.1 96.9

Source: CDC, Enhanced Viral Hepatitis Surveillance Sites.
Abbreviations: FL, Florida; MA, Massachusetts; MI, Michigan; NYS, New York State; Phil, Philadelphia; SF, San Francisco; WA, Washington State
*Florida DOH only reported cases from the following 10 counties: Alachua, Broward, Hillsborough, Miami-Dade, Orange, Palm Beach, Pinellas, Polk, Sarasota, and Seminole
Cases and population estimates from New York excluded those who resided in New York City because New York City was not included in the reported case counts.
§The denominator used to calculate proportions was the total number of cases reported for each site.
NH: Non-Hispanic
** Cases can be reported with more than one laboratory test result.
†† Population estimates for the United States: https://www.census.gov/quickfacts/table/PST045216/00.
HCV: Hepatitis C virus; Anti-HCV: Hepatitis C Antibody: HCV RNA: Ribonucleic acid.

Table 4.5. Number and rate* of hepatitis C-related deaths, by demographic characteristic and year — United States, 2011-2015

Demographic characteristic
2011
2012
2013
2014
2015
No. Rate No. Rate No. Rate No. Rate No. Rate
Age Group (years)§ 0–34 128 0.09 158 0.11 121 0.08 162 0.11 196 0.13
35–44 696 1.71 622 1.54 573 1.42 552 1.36 597 1.47
45–54 5,073 11.34 4,749 10.73 4,344 9.93 4,118 9.48 3,676 8.51
55–64 8,330 21.89 9,235 23.93 9,899 25.18 9,999 24.95 9,702 23.73
65–74 2,136 9.50 2,515 10.49 3,004 11.91 3,390 12.84 4,023 14.60
>75 1,357 7.18 1,369 7.15 1,425 7.31 1,433 7.22 1,434 7.10
Race/ ethnicity White, NH (non-Hispanic) 11,196 4.19 11,839 4.35 12,219 4.40 12,455 4.46 12,355 4.38
Black, NH 3,167 7.89 3,232 7.81 3,520 8.35 3,540 8.12 3,606 8.14
Hispanic 2,555 7.15 2,668 7.19 2,699 6.91 2,767 6.81 2,699 6.40
Asian/Pacific Islander 455 3.14 472 3.15 495 3.09 438 2.56 445 2.49
American Indian/Alaska Native 275 10.61 313 11.81 324 12.22 317 11.2 367 12.95
Sex Male 12,651 7.11 13,300 7.31 13,745 7.40 13,998 7.39 14,095 7.31
Female 5,070 2.70 5,350 2.77 5,623 2.85 5,661 2.81 5,534 2.71
Overall 17,721 4.82 18,650 4.96 19,368 5.03 19,659 5.01 19,629 4.91

Source: CDC, National Vital Statistics System.
*Rates for race, sex, and overall total are age-adjusted per 100,000 U.S. standard population in 2000.
Cause of death is defined as the underlying cause of death or one of the multiple causes of death and is based on the International Classification of Diseases, 10th Revision (ICD-10) codes B17.1, and B18.2 (hepatitis C).
§One death in 2011, two deaths in 2012, two deaths in 2013, five deaths in 2014, and one death in 2015 are not represented under the age category due to missing age data.
The race/ethnicity category was added starting in 2010 to incorporate bridged race categories. 73 deaths in 2011, 126 deaths in 2012, 111 deaths in 2013, 142 deaths in 2014, and 157 in 2015 are not represented under the race/ethnicity category due to missing data.

Figure 4.1. Reported number of acute hepatitis C cases — United States, 2000–2015
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Figure 4.2. Incidence of acute hepatitis C, by age group — United States, 2000–2015
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Figure 4.3. Incidence of acute hepatitis C, by sex — United States, 2000–2015
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Figure 4.4. Incidence of acute hepatitis C, by race/ethnicity — United States, 2000–2015
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Figure 4.5. Availability of information on risk exposures/behaviors associated with acute hepatitis C — United States, 2015
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Figure 4.6a. Acute hepatitis C reports, by risk exposure/behavior — United States, 2015
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Figure 4.6b. Acute hepatitis C reports, by risk exposure/behavior — United States, 2015
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Map 4.1. 2015 State Acute Hepatitis C Incidence Compared to Healthy People 2020 National Goal
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