Numbers and rates* of deaths with Hepatitis A virus infection listed as a cause of death† among residents, by demographic characteristics — United States, 2017–2021
| Characteristics | 2017 No. | 2017 Rate* (95% CI) | 2018 No. | 2018 Rate* (95% CI) | 2019 No. | 2019 Rate* (95% CI) | 2020 No. | 2020 Rate* (95% CI) | 2021 No. | 2021 Rate* (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|
| Total | 91 | 0.02 (0.02 – 0.03) |
171 | 0.05 (0.04 – 0.06) |
225 | 0.04 (0.03 – 0.05) |
179 | 0.04 (0.03 – 0.05) |
135 | 0.03 (0.02 – 0.03) |
| Age (Years) | ||||||||||
| 0–44 | 9 | UR | 33 | 0.02 (0.01 – 0.02) |
24 | 0.01 (0.01 – 0.02) |
19 | UR | 12 | UR |
| 45–64 | 35 | 0.04 (0.03 – 0.06) |
72 | 0.09 (0.07 – 0.11) |
118 | 0.14 (0.12 – 0.17) |
72 | 0.09 (0.07 – 0.11) |
52 | 0.06 (0.05 – 0.08) |
| ≥65 | 47 | 0.09 (0.07 – 0.12) |
66 | 0.13 (0.10 – 0.16) |
83 | 0.15 (0.12 – 0.19) |
88 | 0.16 (0.13 – 0.19) |
71 | 0.13 (0.10 – 0.16) |
| Sex | ||||||||||
| Male | 63 | 0.03 (0.02 – 0.03) |
115 | 0.07 (0.06 – 0.08) |
159 | 0.09 (0.07 – 0.10) |
120 | 0.06 (0.05 – 0.07) |
89 | 0.05 (0.04 – 0.06) |
| Female | 28 | 0 (0.00 – 0.00) |
56 | 0.02 (0.02 – 0.03) |
66 | 0.04 (0.03 – 0.05) |
59 | 0.01 (0.01 – 0.02) |
46 | 0.02 (0.01 – 0.03) |
| Race/Ethnicity | ||||||||||
| White, Non-Hispanic | 69 | 0.02 (0.02 – 0.03) |
150 | 0.06 (0.05 – 0.07) |
194 | 0.09 (0.07 – 0.10) |
146 | 0.05 (0.04 – 0.06) |
103 | 0.04 (0.03 – 0.05) |
| Other or not stated | 22 | S | 21 | S | 31 | S | 33 | S | 32 | S |
Source: CDC, National Center for Health Statistics (NCHS), Multiple Cause of Death on CDC WONDER online database. Data for 2017 are from the 1999–2020 bridged-race file and data for 2018–2021 are from the 2018–2021 single-race file. Single-race and bridged-race categories are not directly comparable (see Technical Notes). Data are based on information from all death certificates filed in the vital records offices of the 50 states and the District of Columbia through the Vital Statistics Cooperative Program. Deaths of nonresidents (e.g., nonresident aliens, nationals living abroad, residents of Puerto Rico, Guam, the Virgin Islands, and other US territories) and fetal deaths are excluded. Accessed at CDC Wonder on March 13, 2023. CDC WONDER data set documentation and technical methods can be accessed here.
* Rates for race/ethnicity, sex, and the overall total are age-adjusted per 100,000 US standard population during 2000 by using the following age group distribution (in years): <1, 1–4, 5–14, 15–24, 25–34, 35–44, 45–54, 55–64, 65–74, 75–84, and ≥85. For age-adjusted death rates, the age-specific death rate is rounded to one decimal place before proceeding to the next step in the calculation of age-adjusted death rates for NCHS Multiple Cause of Death on CDC WONDER. This rounding step might affect the precision of rates calculated for small numbers of deaths. Missing data are not included.
† Cause of death is defined as one of the multiple causes of death and is based on the International Classification of Diseases, 10th Rev. (ICD-10) codes B15 (hepatitis A).
UR: Unreliable rate. Rates where death counts were less than 20 were not displayed because of the instability associated with those rates.
S: Suppressed. CDC WONDER did not have the functionality to calculate rates for the “Other or not stated”’ race/ethnicity group.
* Rates for race/ethnicity, sex, and the overall total are age-adjusted per 100,000 US standard population during 2000 by using the following age group distribution (in years): <1, 1–4, 5–14, 15–24, 25–34, 35–44, 45–54, 55–64, 65–74, 75–84, and ≥85. For age-adjusted death rates, the age-specific death rate is rounded to one decimal place before proceeding to the next step in the calculation of age-adjusted death rates for NCHS Multiple Cause of Death on CDC WONDER. This rounding step might affect the precision of rates calculated for small numbers of deaths. Missing data are not included.
† Cause of death is defined as one of the multiple causes of death and is based on the International Classification of Diseases, 10th Rev. (ICD-10) codes B15 (hepatitis A).
UR: Unreliable rate. Rates where death counts were less than 20 were not displayed because of the instability associated with those rates.
S: Suppressed. CDC WONDER did not have the functionality to calculate rates for the “Other or not stated”’ race/ethnicity group.
Hepatitis A is a self-limited disease that does not result in chronic infection and rarely results in death. In 2021, a total of 135 deaths with hepatitis A virus infection listed as a cause of death were reported among US residents in the US Multiple Cause of Death data from the National Center for Health Statistics, resulting in an age-adjusted death rate of 0.03 per 100,000 population. The 2021 hepatitis A-associated mortality rate was highest among persons aged 65 years and older (0.13 deaths per 100,000 population) and among males (0.05 deaths per 100,000 population). Because of the low number of reported deaths, further stratification by age, race and ethnicity categories, state, and US Department of Health and Human Services region was not possible because of the instability associated with the rates.
Hepatitis A Figures and Tables
- Figure 1.1. Number of reported cases of hepatitis A virus infection and estimated infections — United States, 2014–2021
- Figure 1.2. Rates of reported cases of hepatitis A virus infection, by state or jurisdiction — United States, 2020–2021
- Figure 1.3. Rates of reported cases of hepatitis A virus infection, by state or jurisdiction — United States, 2021
- Figure 1.4. Rates of reported cases of hepatitis A virus infection, by age group — United States, 2006–2021
- Figure 1.5. Rates of reported cases of hepatitis A virus infection, by sex — United States, 2006–2021
- Figure 1.6. Rates of reported cases of hepatitis A virus infection, by race/ethnicity — United States, 2006–2021
- Figure 1.7. Availability of information regarding risk behaviors or exposures associated with reported cases of hepatitis A virus infection — United States, 2021
- Table 1.1. Numbers and rates of reported cases of hepatitis A virus infection, by state or jurisdiction — United States, 2017–2021
- Table 1.2. Numbers and rates of reported cases of hepatitis A virus infection, by demographic characteristics — United States, 2017–2021
- Table 1.3. Reported risk behaviors or exposures among reported cases of hepatitis A virus infection — United States, 2021
- Table 1.4. Numbers and rates of deaths with hepatitis A virus infection listed as a cause of death among residents, by demographic characteristics — United States, 2017–2021