Numbers and rates* of deaths with hepatitis C listed as a cause of death† among residents, by state or jurisdiction — United States, 2016-2020
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Source: CDC, National Center for Health Statistics, Multiple Cause of Death 1999–2020 on CDC WONDER Online Database. Data are from the 2016–2020 Multiple Cause of Death files and are based on information from all death certificates filed in the vital records offices of the 50 states and the District of Columbia through the Vital Statistics Cooperative Program. Deaths of nonresidents (e.g., nonresident aliens, nationals living abroad, residents of Puerto Rico, Guam, the Virgin Islands, and other US territories) and fetal deaths are excluded. Numbers are slightly lower than previously reported for 2016 because of NCHS standards that restrict displayed data to US residents. Accessed at http://wonder.cdc.gov/mcd-icd10.html on January 13, 2022. CDC WONDER data set documentation and technical methods can be accessed here.
* Rates are age-adjusted per 100,000 US standard population during 2000 by using the following age group distribution (in years): <1, 1–4, 5–14, 15–24, 25–34, 35–44, 45–54, 55–64, 65–74, 75– 84, and ≥85. For age-adjusted death rates, the age-specific death rate is rounded to 1 decimal place before proceeding to the next step in the calculation of age-adjusted death rates for NCHS Multiple Cause of Death on CDC WONDER. This rounding step might affect the precision of rates calculated for small numbers of deaths. Missing data are not included.
† Cause of death is defined as one of the multiple causes of death and is based on the International Classification of Diseases, 10th Rev. (ICD-10) codes B17.1, and B18.2 (hepatitis C).
During 2020, a total of 14,863 hepatitis C-associated deaths were reported in the US Multiple Cause of Death data from the National Center for Health Statistics. Although death certificate data can help characterize deaths in the United States associated with hepatitis C, underreporting of hepatitis C as a primary or underlying cause of death does occur.
Treatment of hepatitis C with direct-acting antiviral agents and sustained viral response is associated with reductions in mortality among persons with chronic hepatitis C. During 2020, the age-adjusted mortality rate was 3.45 deaths per 100,000 population, representing an approximate 22% decrease from the corresponding rate during 2016. However, in 2020 the age-adjusted mortality rate for hepatitis C-associated deaths was higher than the 2019 rate (3.33 deaths per 100,000 population).
The overall increase in the US death rate due to COVID-19 may have had some impact. The highest mortality rates in 2020 were observed in Oklahoma and the District of Columbia (10.28 and 9.65 deaths per 100,000 population, respectively), whereas the lowest rates were observed in Illinois and Delaware (1.68 and 1.94 deaths per 100,000 population, respectively). Three states (California, Texas, and Florida) had the highest number of hepatitis C-associated deaths reported, accounting for more than 30% of all the deaths reported nationally during 2020.
- Figure 3.1. Number of reported cases of acute hepatitis C virus infection and estimated infections — United States, 2013-2020
- Figure 3.2. Rates of reported cases of acute hepatitis C virus infection, by state or jurisdiction — United States, 2019-2020
- Figure 3.3. Rates of reported cases of acute hepatitis C virus infection, by state or jurisdiction — United States, 2020
- Figure 3.4. Rates of reported cases of acute hepatitis C virus infection, by age group — United States, 2005-2020
- Figure 3.5. Rates of reported cases of acute hepatitis C virus infection, by sex — United States, 2005-2020
- Figure 3.6. Rates of reported cases of acute hepatitis C virus infection, by race/ethnicity — United States, 2005-2020
- Figure 3.7. Availability of information on risk behaviors or exposures associated with reported cases of acute hepatitis C virus infection — United States, 2020
- Figure 3.8. Number of newly reported chronic hepatitis C virus infection cases by sex and age — United States, 2020
- Figure 3.9. Rates of death with hepatitis C virus infection listed as a cause of death among residents, by state or jurisdiction — United States, 2020
- Table 3.1. Numbers and rates of reported cases of acute hepatitis C virus infection, by state or jurisdiction — United States, 2016-2020
- Table 3.2. Numbers and rates of reported cases of acute hepatitis C virus infection, by demographic characteristics — United States 2016-2020
- Table 3.3. Reported risk behaviors or exposures among reported cases of acute hepatitis C virus infection — United States, 2020
- Table 3.4. Number of newly reported cases of perinatal hepatitis C virus infection, by state or jurisdiction — United States, 2020
- Table 3.5. Number and rate of newly reported cases of chronic hepatitis C virus infection, by state or jurisdiction — United States, 2020
- Table 3.6. Number and rate of newly reported cases of chronic hepatitis C virus infection, by demographic characteristics — United States, 2020
- Table 3.7. Numbers and rates of deaths with hepatitis C listed as a cause of death among residents, by state or jurisdiction — United States, 2016-2020
- Table 3.8. Numbers and rates of deaths with hepatitis C virus infection listed as a cause of death among residents, by demographic characteristics — United States, 2016-2020
Source:
- Spradling PR, Zhong Y, Moorman AC, et al. The persistence of underreporting of hepatitis C as an underlying or contributing cause of death, 2011–2017. Clin Infect Dis. 2021 Sep 7;73(5):891-894. doi: 10.1093/cid/ciab108. PMID: 33561187.