Number and rate* of newly reported cases† of chronic Hepatitis C virus infection, by demographic characteristics — United States, 2021

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◀ Table 3.5
Table 3.7 ▶
Number and rate* of newly reported cases† of chronic Hepatitis C virus infection, by demographic characteristics — United States, 2021
The number and rate of newly reported cases of chronic hepatitis C virus infection, by demographic characteristics. The first column lists the demographic characteristics (age, sex, race and ethnicity, urbanicity, and US Department of Health and Human Services region). The second column provides the number of newly reported chronic hepatitis C cases, and the third column provides rates, expressed as reported cases per 100,000 population, for each demographic category during 2021.
Characteristics No. Rate*
Total§ 107,540 39.8
Age (Years)
0–19 935 1.4
20–29 14,850 41.9
30–39 27,578 74.9
40–49 18,089 54.6
50–59 17,501 50.2
≥60 24,149 37.8
Sex
Male 69,927 52.3
Female 37,205 27.3
Race/Ethnicity
American Indian/Alaska Native, non-Hispanic 1,327 68.9
Asian/Pacific Islander, non-Hispanic 764 4.5
Black, non-Hispanic 9,537 27.9
White, non-Hispanic 47,868 29.2
Hispanic 4,604 10.0
Urbanicity 
Urban 84,588 36.3
Rural 21,388 57.9
HHS Region**
Region 1: Boston 4,213 30.1
Region 2: New York 7,061 24.3
Region 3: Philadelphia 16,234 53.1
Region 4: Atlanta 30,152 57.2
Region 5: Chicago 14,044 30.5
Region 6: Dallas 8,307 60.4
Region 7: Kansas City 6,057 42.5
Region 8: Denver 4,461 35.7
Region 9: San Francisco 11,621 27.4
Region 10: Seattle 5,390 36.9
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Source: CDC, National Notifiable Diseases Surveillance System.
* Rates per 100,000 population.
† Reported confirmed cases. For the case definition, see Chronic Hepatitis C.
§ Numbers reported in each category may not add up to the total number of reported cases in a year due to cases with missing data or, in the case of race/ethnicity, cases categorized as “Other.”
Urbanicity was categorized according to the 2013 National Center for Health Statistics (NCHS) urban-rural classification scheme for counties and county-equivalent entities. Large central metro, large fringe metro, medium metro, and small metro counties were grouped as urban. Micropolitan and noncore counties were grouped as rural.
** US Department of Health and Human Services regions were categorized according to the grouping of states and US territories assigned under each of the 10 Department of Health and Human Services regional offices. For the purposes of this report, regions with US territories (Region 2 and Region 9) contain data from states only.

During 2021, the rates of newly reported chronic hepatitis C were highest among persons aged 30–39 years, males, non-Hispanic American Indian/Alaska Native persons, those living in rural areas, and persons in US Department of Health and Human Services Region 6 (Arkansas, Louisiana, New Mexico, Oklahoma, and Texas). Among all newly reported chronic hepatitis C cases during 2021, 27% occurred among persons aged 30–39 years, 65% occurred among males, and 80% occurred in urban areas. Race and ethnicity information was only available for 70,129 (65%) cases of newly reported chronic hepatitis C; after excluding cases with missing race and ethnicity information, 68% of cases occurred among non-Hispanic White persons.  Variations of disease rates by race or ethnicity may reflect systemic cultural, behavioral, environmental, and social factors, including structural racism.

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