Number of reported cases* of acute Hepatitis C virus infection and estimated infections — United States, 2014–2021

Number of reported cases* of acute hepatitis C virus infection and estimated infections† — United States, 2014–2021

Source: CDC, National Notifiable Diseases Surveillance System.
* Reported confirmed cases. For the case definition, see Acute Hepatitis C.
† The number of estimated viral hepatitis infections was determined by multiplying the number of reported cases that met the classification criteria for a confirmed case by a factor that adjusted for underascertainment and underreporting. The 95% bootstrap confidence intervals for the estimated number of infections are displayed in the Appendix.

The number of acute hepatitis C cases reported in the United States increased every year during 2014–2021. During 2021, a total of 5,023 acute cases were reported, corresponding to 69,800 estimated infections after adjusting for case underascertainment and underreporting.1 The number of cases reported during 2021 corresponded to a 5% increase from the 4,798 cases reported during 2020 and a 129% increase from the 2,194 cases reported during 2014.

While the COVID-19 pandemic disrupted health care access during 2020 and 2021, any anticipated reductions in the number of reported acute hepatitis C cases was likely offset by a change to the acute hepatitis C case definition in 2020. The new case definition was designed to better characterize cases classified as acute hepatitis C (see Technical Notes).

Hepatitis C Figures and Tables


  1. Klevens RM, Liu, S, Roberts H, et al. Estimating acute viral hepatitis infections from nationally reported cases. Am J Public Health 2014; 104:482. PMC3953761.