Rates* of reported cases of acute Hepatitis C virus infection, by age group — United States, 2006–2021

Rates* of reported cases† of acute hepatitis C virus infection, by age group — United States, 2006–2021

Source: CDC, National Notifiable Diseases Surveillance System.
* Rates per 100,000 population. Beginning in 2021, single-race population estimates are used for rate calculations. For prior years, bridged-race population estimates are used.
† Reported confirmed cases. For the case definition, see Acute Hepatitis C.

Since 2010, rates of reported cases of acute hepatitis C consistently increased among nearly all age groups of 20 years and older, then during 2019–2021 rates declined each year among persons aged 20–29 years. In 2021, the rate of reported cases of acute hepatitis C remained the highest among persons aged 30–39 years (3.5 cases per 100,000 population) and 20–29 years (2.5 cases per 100,000 population), similar to age groups at highest risk for fatal overdose in the United States and age at initiation of injection drug use among certain US populations.1 Rates have consistently been lowest among those aged less than 20 years or 60 years and older; however, rates have been increasing among those aged 60 years and older since 2016.

Hepatitis C Figures and Tables


  1. Jalal H, Buchanich JM, Sinclair DR, et al. Age and generational patterns of overdose death risk from opioids and other drugs. Nat Med 2020;26:699–704. doi: 10.1038/s41591-020-0855.