Live Attenuated Influenza Vaccine [LAIV] (The Nasal Spray Flu Vaccine)

Brand name: FluMist Quadrivalent

Vaccine Information Statements (VIS)

Flu VISs are no longer updated every year. The edition dated 8/15/2019 should be used for the current flu season.

VIS Statement

Several formats including PDF available

Nasal Spray (Live Attenuated
Influenza Vaccine (LAIV)) VIS

What flu viruses does the nasal spray vaccine protect against?

All nasal spray influenza (flu) vaccines for the 2020-2021 season are quadrivalent, meaning they will be made using four flu viruses: an influenza A(H1N1) virus, an influenza A(H3N2) virus and two influenza B viruses.

Learn more about the vaccine composition of the 2020-2021 flu season vaccines.

Are any of the available flu vaccines recommended over the others?

For the 2020-2021 flu season, the Advisory Committee on Immunization Practices (ACIP) recommends annual influenza (flu) vaccination for everyone 6 months and older with any licensed, influenza vaccine that is appropriate for the recipient’s age and health status, including inactivated influenza vaccine (IIV), recombinant influenza vaccine (RIV), or live attenuated nasal spray influenza vaccine (LAIV4) with no preference expressed for any one vaccine over another.

There are many vaccine options to choose from, but the most important thing is for all people 6 months and older to get a flu vaccine every year. If you have questions about which vaccine is best for you, talk to your doctor or other health care professional.

Who can be vaccinated with the nasal spray flu vaccine?

The nasal spray flu vaccine is approved for use in healthy non-pregnant individuals, 2 years through 49 years old. People with certain medical conditions should not receive the nasal spray flu vaccine.

Who should not be vaccinated with the nasal spray flu vaccine?

Some people should not get the nasal spray flu vaccine:

  • Children younger than 2 years
  • Adults 50 years and older
  • People with a history of severe allergic reaction to any ingredient of the vaccine or to a previous dose of any influenza vaccine
  • Children 2 years through 17 years old who are receiving aspirin- or salicylate-containing medications.
  • Children 2 years through 4 years old who have asthma or who have had a history of wheezing in the past 12 months
  • People with weakened immune systems (immunosuppression) from any cause
  • People who care for severely immunocompromised persons who require a protected environment (or otherwise avoid contact with those persons for 7 days after getting the nasal spray vaccine)
  • People without a spleen, or with a non-functioning spleen
  • Pregnant women
  • People with an active leak between the cerebrospinal fluid and the mouth, nose, ear, or other place within the skull
  • People with cochlear implants
  • People who have taken flu antiviral drugs within the previous 48 hours for oseltamivir and zanamivir, previous 5 days for peramivir, and previous 17 days for baloxavir.

In addition, the following conditions are precautions to the use of the nasal spray flu vaccine:

  • Asthma in people aged 5 years and older.
  • Other underlying medical conditions that can put people at higher risk of serious flu complications. These include conditions such as lung disease, heart disease (except isolated hypertension), kidney disease (like diabetes), kidney or liver disorders, neurologic/neuromuscular, or metabolic disorders. “People at High Risk of Developing Flu–Related Complications.”
  • Moderate or severe acute illness with or without fever.
  • Guillain-Barré Syndrome within 6 weeks following a previous dose of flu vaccine.

How effective is the nasal spray seasonal flu vaccine?

Flu vaccine effectiveness (VE) can vary from year to year, among different age and risk groups, by vaccine type, and even by virus type and subtype. Prior to the 2009 flu pandemic, the nasal spray vaccine was found to be effective against different flu viruses. After the 2009 pandemic, several U.S. studies among 2 through 17-year-olds found that the nasal spray vaccine was as effective against influenza B viruses and influenza A(H3N2) viruses as inactivated influenza vaccines, but was less effective than inactivated flu vaccines against the 2009 pandemic H1N1 viruses. These data led ACIP and CDC to recommend against use of the nasal spray vaccine for the 2016-17 and 2017-18 seasons.

Since the 2017-2018 season, the manufacturer of nasal spray vaccine has used new influenza A(H1N1) vaccine virus ingredients in production.  Because of limited use, there have been no effectiveness estimates in the United States since LAIV was recommended again in the 2018-2019 influenza season. Data from other countries have demonstrated protection from LAIV to be similar to that of standard-dose, egg-based inactivated flu vaccine in children.

Should the nasal spray flu vaccine be given to patients with chronic diseases?

LAIV is not recommended for people with some  chronic health conditions because the safety and effectiveness of this vaccine in people with those conditions has not been established.

See Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices—United States, 2020—21 Influenza Season for a list of contraindications and precautions for the nasal spray vaccine

Should pregnant and postpartum women avoid contact with people who were recently vaccinated with the nasal spray vaccine?

Pregnant and postpartum women do not need to avoid contact with persons recently vaccinated with the nasal spray flu vaccine. However, the nasal spray flu vaccine should not be given to women who are pregnant. Postpartum women can receive a flu shot or the nasal spray flu vaccine.

Are there any contraindications to giving breastfeeding mothers the nasal spray vaccine?

Breastfeeding is not a contraindication for the nasal spray vaccine. Breastfeeding mothers younger than 50 years can get the nasal spray flu vaccine as long as they do not have a contraindication to getting that vaccine. See Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices—United States, 2020—21 Influenza Season for a list of contraindications and precautions for the nasal spray vaccine.

Can the nasal spray flu vaccine be given to patients when they are ill?

The nasal spray flu vaccine can be given to people with mild illnesses (e.g., diarrhea or mild upper respiratory tract infection with or without fever). However, nasal congestion might limit delivery of the vaccine to the nasal lining, and so delaying vaccination with LAIV until the nasal congestion is reduced or use of an age-appropriate injectable vaccine instead of LAIV should be considered. People with moderate or severe illness, with or without fever, should generally wait to be vaccinated until they have recovered. Your health care provider can provide advice about when to get vaccinated if you are feeling ill.

Can nasal spray flu vaccine give me flu?

Flu vaccines do not cause flu illness. The nasal spray flu vaccine contains weakened (attenuated) viruses, so that they will not cause flu illness. The weakened viruses are cold-adapted, which means they are designed to only multiply at the cooler temperatures found within the nose, and not the lungs or other areas where warmer temperatures exist.

What are the side effects that could occur with the nasal spray flu vaccine?

The viruses in the nasal spray flu vaccine are weakened and do not cause severe symptoms often associated with flu illness. In children, side effects from the nasal spray may include:

  • Runny nose
  • Wheezing
  • Headache
  • Vomiting
  • Muscle aches
  • Fever (low grade)
  • Sore throat (in older children)

In adults, side effects from the nasal spray vaccine may include:

  • Runny nose
  • Headache
  • Cough

If these problems occur, they begin soon after vaccination and usually are mild and short-lived. People sometimes faint after medical procedures, including vaccination. Tell your provider if you feel dizzy or have vision changes or ringing in the ears. Rarely, people can experience a severe allergic reaction after a flu vaccine (or any vaccine); there are about 1-2 cases of severe allergic reactions per million flu vaccine doses administered and these reactions can be treated with medication. People who think that they have been injured by a flu vaccine can file a claim with the National Vaccine Injury Compensation Program (VICP)external icon.

More information about the safety of flu vaccines is available at Influenza Vaccine Safety.

Vaccine Information Statements (VIS)

Flu VISs are no longer updated every year. The edition dated 8/15/2019 should be used for the current flu season.

Nasal Spray (Live Attenuated Influenza Vaccine (LAIV)) VIS