TABLE 1. Influenza vaccines — United States, 2020–21 influenza season*

TABLE 1. Influenza vaccines — United States, 2020–21 influenza season*
Trade name
(Manufacturer)
Presentation Age indication HA (IIVs and RIV4) or virus count (LAIV4) for each vaccine virus (per dose) Route Mercury (from thimerosal) μg/0.5mL
IIV4
Standard dose, egg based†
Afluria Quadrivalent
(Seqirus)
0.25-mL PFS§ 6 through 35 mos 7.5 μg/0.25 mL
15 μg/0.5 mL
IM
0.5-mL PFS ≥3 yrs
5.0-mL MDV§ ≥6 mos
(needle/syringe)
18 through 64 yrs
(jet injector)
24.5
Fluarix Quadrivalent
(GlaxoSmithKline)
0.5-mL PFS ≥6 mos 15 μg/0.5 mL IM
FluLaval Quadrivalent
(GlaxoSmithKline)
0.5-mL PFS ≥6 mos 15 μg/0.5 mL IM
Fluzone Quadrivalent
(Sanofi Pasteur)
0.5-mL PFS** ≥6 mos 15 μg/0.5 mL IM
0.5-mL SDV ≥6 mos
5.0-mL MDV ≥6 mos 25
Standard dose, cell culture based (ccIIV4)
Flucelvax Quadrivalent
(Seqirus)
0.5-mL PFS ≥4 yrs 15 μg/0.5 mL IM
5.0-mL MDV ≥4 yrs 25
High dose, egg based† (HD-IIV4)
Fluzone High-Dose Quadrivalent
(Sanofi Pasteur)
0.7-mL PFS ≥65 yrs 60 μg/0.7 mL IM
Standard dose, egg based† with MF59 adjuvant (aIIV4)
Fluad Quadrivalent
(Seqirus)
0.5-mL PFS ≥65 yrs 15 μg/0.5 mL IM
IIV3
Standard dose, egg based† with MF59 adjuvant (aIIV3)
Fluad
(Seqirus)
0.5-mL PFS ≥65 yrs 15 μg/0.5 mL IM
RIV4
Recombinant HA
Flublok Quadrivalent
(Sanofi Pasteur)
0.5-mL PFS ≥18 yrs 45 μg/0.5 mL IM
LAIV4
Egg based†
FluMist Quadrivalent
(AstraZeneca)
0.2-mL prefilled single-use intranasal sprayer 2 through 49 yrs 106.5-7.5 fluorescent focus units/0.2 mL NAS

Abbreviations: ACIP = Advisory Committee on Immunization Practices; FDA = Food and Drug Administration; HA = hemagglutinin; IIV3 = inactivated influenza vaccine, trivalent; IIV4 = inactivated influenza vaccine, quadrivalent; IM = intramuscular; LAIV4 = live attenuated influenza vaccine, quadrivalent; MDV = multidose vial; NAS = intranasal; PFS = prefilled syringe; RIV4 = recombinant influenza vaccine, quadrivalent; SDV = single-dose vial.

* Vaccination providers should consult FDA-approved prescribing information for 2020–21 influenza vaccines for the most complete and updated information, including (but not limited to) indications, contraindications, warnings, and precautions. Package inserts for U.S.-licensed vaccinesexternal icon. Availability and characteristics of specific products and presentations might change and/or differ from what is described in this table and in the text of the full report.

† History of severe allergic reaction (e.g., anaphylaxis) to egg is a labeled contraindication to the use of most IIVs and LAIV4. However, ACIP recommends that persons with a history of egg allergy may receive any licensed, recommended influenza vaccine that is otherwise appropriate for their age and health status. Those who report having had reactions to egg involving symptoms other than urticaria (e.g., angioedema or swelling, respiratory distress, lightheadedness, or recurrent emesis) or who required epinephrine or another emergency medical intervention should be vaccinated in an inpatient or outpatient medical setting (including, but not necessarily limited to, hospitals, clinics, health departments, and physician offices) supervised by a health care provider who is able to recognize and manage severe allergic reactions, if a vaccine other than ccIIV4 or RIV4 is used.

§ The dose volume for Afluria Quadrivalent is 0.25 mL for children aged 6 through 35 months and 0.5 mL for persons aged ≥3 years.

IM-administered influenza vaccines should be given by needle and syringe only, with the exception of the MDV presentation of Afluria Quadrivalent, which may alternatively be given by the PharmaJet Stratis jet injector for persons aged 18 through 64 years only. For adults and older children, the recommended site for intramuscular influenza vaccination is the deltoid muscle. The preferred site for infants and young children is the anterolateral aspect of the thigh. Additional guidance regarding site selection and needle length for intramuscular administration is available in the ACIP General Best Practice Guidelines for Immunization.

** Fluzone Quadrivalent is currently licensed for ages 6 through 35 months at either 0.25 mL or 0.5 mL per dose; however, 0.25-mL prefilled syringes are not expected to be available for the 2020–21 influenza season. If a prefilled syringe of Fluzone Quadrivalent is used for a child in this age group, the dose volume will be 0.5mL per dose.