TABLE. Influenza vaccines — United States, 2021–22 influenza season*

Trade name (manufacturer) Presentations Age indication µg HA (IIV4s and RIV4)
or virus count (LAIV4)
for each vaccine virus (per dose)
Route Mercury
(from thimerosal, if present),
µg/0.5 mL
Influenza vaccines — United States, 2021–22 influenza season*
IIV4 (standard-dose, egg-based vaccines)
Afluria Quadrivalent
(Seqirus)
0.25-mL PFS§ 6 through 35 mos§ 7.5 µg/0.25 mL IM
0.5-mL PFS§ ≥3 yrs§ 15 µg/0.5 mL IM
5.0-mL MDV§ ≥6 mos§
(needle/syringe)
18 through 64 yrs
(jet injector)
15 µg/0.5 mL IM 24.5
Fluarix Quadrivalent
(GlaxoSmithKline)
0.5-mL PFS ≥6 mos 15 µg/0.5 mL IM
FluLaval Quadrivalent
(GlaxoSmithKline)
0.5-mL PFS ≥6 mos 15 µg/0.5 mL IM
Fluzone Quadrivalent
(Sanofi Pasteur)
0.5-mL PFS** ≥6 mos** 15 µg/0.5 mL IM
0.5-mL SDV** ≥6 mos** 15 µg/0.5 mL IM
5.0-mL MDV** ≥6 mos** 15 µg/0.5 mL
7.5 µg/0.25 mL
IM 25
ccIIV4 (standard-dose, cell culture–based vaccine)
Flucelvax Quadrivalent
(Seqirus)
0.5-mL PFS ≥2 yrs 15 µg/0.5 mL IM
5.0-mL MDV ≥2 yrs 15 µg/0.5 mL IM 25
HD-IIV4 (high-dose, egg-based vaccine)
Fluzone High-Dose Quadrivalent
(Sanofi Pasteur)
0.7-mL PFS ≥65 yrs 60 µg/0.7 mL IM
aIIV4 (standard-dose, egg-based vaccine with MF59 adjuvant)
Fluad Quadrivalent
(Seqirus)
0.5-mL PFS ≥65 yrs 15 µg/0.5 mL IM
RIV4 (recombinant HA vaccine)
Flublok Quadrivalent
(Sanofi Pasteur)
0.5-mL PFS ≥18 yrs 45 µg/0.5 mL IM
LAIV4 (egg-based vaccine)
FluMist Quadrivalent
(AstraZeneca)
0.2-mL prefilled single-use intranasal sprayer 2 through 49 yrs  

106.5–7.5 fluorescent focus units/0.2 mL

NAS

Abbreviations: ACIP = Advisory Committee on Immunization Practices; FDA = Food and Drug Administration; HA = hemagglutinin; IIV4 = inactivated influenza vaccine, quadrivalent; IM = intramuscular; LAIV4 = live attenuated influenza vaccine, quadrivalent; MDV = multidose vial; mos = months; NAS = intranasal; PFS = prefilled syringe; RIV4 = recombinant influenza vaccine, quadrivalent; SDV = single-dose vial

* Vaccination providers should consult FDA-approved prescribing information for 2021–22 influenza vaccines for the most complete and updated information, including (but not limited to) indications, contraindications, warnings, and precautions. Package inserts for U.S.-licensed vaccines are available at https://www.fda.gov/vaccines-blood-biologics/approved-products/vaccines-licensed-use-united-statesexternal icon. Availability and characteristics of specific products and presentations might change or differ from what is described in this table and in the text of this report.

Although a history of severe allergic reaction (e.g., anaphylaxis) to egg is a labeled contraindication to the use of egg-based IIV4s and LAIV4, ACIP recommends that persons with a history of egg allergy may receive any licensed, recommended influenza vaccine that is otherwise appropriate for their age and health status. Those who report having had reactions to egg involving symptoms other than urticaria (e.g., angioedema or swelling, respiratory distress, lightheadedness, or recurrent emesis) or who required epinephrine or another emergency medical intervention should be vaccinated in an inpatient or outpatient medical setting (including but not necessarily limited to hospitals, clinics, health departments, and physician offices) supervised by a health care provider who is able to recognize and manage severe allergic reactions, if a vaccine other than ccIIV4 or RIV4 is used.

§The dose volume for Afluria Quadrivalent is 0.25 mL for children aged 6 through 35 months and 0.5 mL for persons aged ≥3 years.

IM-administered influenza vaccines should be given by needle and syringe only, with the exception of the MDV presentation of Afluria Quadrivalent, which may alternatively be given by the PharmaJet Stratis jet injector for persons aged 18 through 64 years only. For adults and older children, the recommended site for intramuscular influenza vaccination is the deltoid muscle. The preferred site for infants and young children is the anterolateral aspect of the thigh. Additional specific guidance regarding site selection and needle length for intramuscular administration is available in the ACIP General Best Practice Guidelines for Immunization, available at https://www.cdc.gov/vaccines/hcp/acip-recs/general-recs/index.html.

** Fluzone Quadrivalent is currently approved for ages 6 through 35 months at either 0.25 mL or 0.5 mL per dose; however, 0.25-mL prefilled syringes are not expected to be available for the 2021–22 influenza season. If a prefilled syringe of Fluzone Quadrivalent is used for a child in this age group, the dose volume will be 0.5 mL per dose.