Effectiveness research assesses whether interventions and strategies to prevent, diagnose, treat, and monitor diabetes work. This research is designed to inform patients, providers, and decision makers which interventions or strategies are most effective for which populations or populations of patients, and under what circumstances.
- Diabetes Prevention Program Outcome Studyexternal icon (DPPOS)
The DPPOS study assesses the long-term effects of the intensive lifestyle intervention or metformin on diabetes-related complications and cancer. This a follow-up study of a multicenter, randomized control trial called the Diabetes Prevention Program (DPP)external icon. The DPP showed that people who are at high risk for type 2 diabetes can prevent or delay the disease by losing a modest amount of weight through lifestyle changes (dietary changes and increased physical activity) and is also cost effective, providing the evidence base for CDC’s National DPP.
- The Action for Health in Diabetes (Look AHEAD)-Extensionexternal icon
The Look AHEAD-Extension study assesses the long-term effect of the intensive lifestyle intervention on life expectancy, health care costs, and the key dimensions of healthy aging (less frailty, reduced diabetic small blood vessel complications, and improved quality of life).
- 30-Year Follow-up of Da Qing Diabetes Prevention Study
The 30-year follow-up of the Da Qing Diabetes Prevention Study (DQDPS) examines the long-term effects of lifestyle changes on major cardiovascular (heart) disease, microvascular (small blood vessel) complications (e.g., eye and kidney diseases), and life expectancy.
- Look AHEAD Research Group, Wadden TA, Chao AM, Anderson H, Annis K, Atkinson K, Bolin P, Brantley P, Clark JM, Coday M, Dutton G, Foreyt JP, Gregg EW, Hazuda HP, Hill JO, Hubbard VS, Jakicic JM, Jeffery RW, Johnson KC, Kahn SE, Knowler WC, Korytkowski M, Lewis CE, Laferrère B, Middelbeek RJ, Munshi MN, Nathan DM, Neiberg RH, Pilla SJ, Peters A, Pi-Sunyer X, Rejeski JW, Redmon B, Stewart T, Vaughan E, Wagenknecht LE, Walkup MP, Wing RR, Wyatt H, Yanovski SZ, Zhang P. Changes in mood and health-related quality of life in Look AHEAD 6 years after termination of the lifestyle intervention.external icon Obesity (Silver Spring). 2021 Aug;29(8):1294–1308.
- Chen Y, Zhang P, Wang J, Gong Q, An Y, Qian X, Zhang B, Li H, Gregg EW, Bennett PH, Li G. Associations of progression to diabetes and regression to normal glucose tolerance with development of cardiovascular and microvascular disease among people with impaired glucose tolerance: a secondary analysis of the 30 year Da Qing Diabetes Prevention Outcome Study.external icon Diabetologia. 2021 Jun;64(6):1279–1287.