Effectiveness research assesses whether interventions and strategies to prevent, diagnose, treat, and monitor diabetes work. This research is designed to inform patients, providers, and decision makers which interventions or strategies are most effective for which populations or populations of patients, and under what circumstances.
- Diabetes Prevention Program Outcome Studyexternal icon (DPPOS)
The DPPOS study assesses the long-term effects of the intensive lifestyle intervention or metformin on diabetes-related complications and cancer. This a follow-up study of a multicenter, randomized control trial called the Diabetes Prevention Program (DPP)external icon. The DPP showed that people who are at high risk for type 2 diabetes can prevent or delay the disease by losing a modest amount of weight through lifestyle changes (dietary changes and increased physical activity) and is also cost effective, providing the evidence base for CDC’s National DPP.
- The Action for Health in Diabetes (Look AHEAD)-Extensionexternal icon
The Look AHEAD-Extension study assesses the long-term effect of the intensive lifestyle intervention on life expectancy, health care costs, and the key dimensions of healthy aging (less frailty, reduced diabetic small blood vessel complications, and improved quality of life).
- 30-Year Follow-up of Da Qing Diabetes Prevention Study
The 30-year follow-up of the Da Qing Diabetes Prevention Study (DQDPS) examines the long-term effects of lifestyle changes on major cardiovascular (heart) disease, microvascular (small blood vessel) complications (e.g., eye and kidney diseases), and life expectancy.
- Neuwahl SJ, Zhang P, Chen H, Shao H, Laxy M, Anderson AM, Craven TE, Hoerger TJ; Look AHEAD Research Group. Patient health utility equations for a type 2 diabetes model.external icon Diabetes Care. 2021 Feb;44(2):381–389.
- Zhang P, Atkinson KM, Bray GA, Chen H, Clark JM, Coday M, Dutton GR, Egan C, Espeland MA, Evans M, Foreyt JP, Greenway FL, Gregg EW, Hazuda HP, Hill JO, Horton ES, Hubbard VS, Huckfeldt PJ, Jackson SD, Jakicic JM, Jeffery RW, Johnson KC, Kahn SE, Killean T, Knowler WC, Korytkowski M, Lewis CE, Maruthur NM, Michaels S, Montez MG, Nathan DM, Patricio J, Peters A, Pi-Sunyer X, Pownall H, Redmon B, Rushing JT, Steinburg H, Wadden TA, Wing RR, Wyatt H, Yanovski SZ; Look AHEAD Research Group. Within-trial cost-effectiveness of a structured lifestyle intervention in adults with overweight/obesity and type 2 diabetes: results from the Action for Health in Diabetes (Look AHEAD) Study.external icon Diabetes Care. 2021 Jan;44(1):67–74.