
Implementing Culturally Tailored Diabetes Prevention in Hispanic Communities: An Integrative Review Using the RE-AIM Framework
SYSTEMATIC REVIEW — Volume 23 — October 29, 2026
Rachell Nguyen, DNP, APRN1 (View author affiliations)
Suggested citation for this article: Nguyen R. Implementing Culturally Tailored Diabetes Prevention in Hispanic Communities: An Integrative Review Using the RE-AIM Framework. Prev Chronic Dis 2026;23:260050. DOI: http://dx.doi.org/10.5888/pcd23.260050.
PEER REVIEWED
What is known on this topic?
Culturally tailored diabetes prevention interventions are effective at reducing diabetes risk among Hispanic adults; however, their translation into routine community practice is limited, despite the population’s high diabetes prevalence.
What is added by this report?
This Reach, Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) framework analysis of 37 studies identified implementation gaps in adoption, sustainability, and male engagement, while documenting successful strategies including community health worker models, community-based delivery, and family-centered programming.
What are the implications for public health practice?
Achieving equitable diabetes prevention requires policy support for community health worker integration, sustainable funding mechanisms beyond time-limited grants, workforce development that addresses bilingual and bicultural shortages, and health care–community partnerships.
Abstract
Introduction
Hispanic adults in the US have disproportionately high rates of diabetes and face persistent barriers to accessing evidence-based prevention programs. Despite the demonstrated efficacy of culturally tailored diabetes prevention interventions, translation into routine community practice is markedly limited. This integrative review examined implementation processes, barriers, and facilitators of culturally tailored diabetes prevention interventions in Hispanic communities, using the Reach, Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) framework to identify strategies that support population-level impact.
Methods
Comprehensive searches of 5 databases (PubMed, CINAHL, Web of Science, EMBASE, ScienceDirect) from 2005 through 2025 identified 69 sources; 37 (empirical studies, study protocols, and reviews) reporting implementation data were analyzed. Data extraction and synthesis aligned with the RE-AIM framework and used constant comparative methods. Quality appraisal used the Johns Hopkins Evidence-Based Practice tool. This review was not registered, consistent with integrative review methods.
Results
Implementation facilitators included cultural concordance, community health worker models, community-based delivery, and family-centered programming. Barriers included funding instability, workforce shortages, male underrepresentation, and limited maintenance data. Interventions achieved clinically meaningful weight loss (3.2 kg–5.8 kg), but real-world outcomes were smaller than those reported in efficacy trials. Community-based organizations were the primary adopters, although resource constraints were common. Only 18% of studies reported outcomes beyond 12 months, limiting the assessment of sustained impact.
Conclusion
Culturally tailored diabetes prevention interventions are effective and acceptable in Hispanic communities; however, implementation gaps in adoption, scaling ability, and sustainability limit population-level impact. Successful translation requires cultural concordance, community partnerships, flexible delivery models, and workforce development. Addressing structural barriers through policy support for community health worker integration, sustainable funding mechanisms, and health care–community partnerships is essential to achieving equitable diabetes prevention at scale.
Introduction
Hispanic adults are the largest ethnic minority group in the US and have a disproportionately high prevalence of type 2 diabetes, nearly 50% higher than that of non-Hispanic White adults, with increased risk and earlier onset of complications, including retinopathy, nephropathy, and cardiovascular disease (1). Despite evidence supporting culturally tailored diabetes prevention interventions, translation into routine community practice is limited (2).
The persistent gap between “what works” in controlled research settings and “what gets implemented” in real-world practice is a barrier to reducing health disparities. Although the National Diabetes Prevention Program (NDPP) has demonstrated efficacy, data show that only 35.5% of participants complete core requirements, with even lower rates among Hispanic participants (3). Programs are limited in Hispanic communities, particularly in rural areas, along with retention challenges and cultural–linguistic barriers that undermine effectiveness (4,5).
Although African American and Asian American communities also have high diabetes risk and face culturally specific barriers to program implementation, each warranting dedicated investigation, the Hispanic population is uniquely underserved by existing NDPP infrastructure, with persistently lower enrollment and completion rates than other high-risk groups (3). The cultural, linguistic, and structural heterogeneity in Hispanic communities, including variation by country of origin, acculturation level, immigration status, and geographic distribution, requires a population-focused implementation science lens.
Implementation science provides frameworks for implementing, adapting, sustaining, and scaling evidence-based interventions across diverse real-world contexts (6). The Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework explicitly addresses implementation dimensions that are overlooked in traditional efficacy research (7). RE-AIM examines 5 interconnected dimensions: reach (proportion and representativeness of participants), effectiveness (impact in real-world settings), adoption (organizational uptake), implementation (fidelity, adaptation, and delivery consistency), and maintenance (sustained effects and organizational continuation).
Although previous reviews examined the effectiveness of culturally tailored diabetes prevention interventions (8), they offered limited guidance on implementation processes, organizational adoption patterns, strategies for balancing fidelity and adaptation, workforce constraints, and factors predicting sustainability.
Health care and public health workforces, including nurses, community health workers, and health educators, play a central role in translating evidence-based prevention into practice; however, implementation strategies that support their success are poorly characterized. This integrative review addresses these gaps by synthesizing implementation science evidence on culturally tailored diabetes prevention for Hispanic adults using the RE-AIM framework. This research sought to answer the following questions:
- What implementation facilitators and barriers affect culturally tailored diabetes prevention interventions for Hispanic adults across RE-AIM domains?
- What evidence-based strategies support the successful adoption, delivery, and sustainability of culturally tailored diabetes prevention in Hispanic communities?
Methods
Design
This integrative review used Whittemore and Knafl’s (9) 5-stage methodology, allowing inclusion of diverse study designs to provide a comprehensive understanding of implementation phenomena. The framework guided data extraction and synthesis across 5 implementation domains. The review followed PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 reporting standards for systematic reviews.
Search strategy
Comprehensive searches were conducted in PubMed, CINAHL, Web of Science, EMBASE, and ScienceDirect from January 2005 through December 2025. Search strategies combined 4 concept domains: diabetes prevention and prediabetes; Hispanic, Latino, Latina, and Latinx populations; cultural adaptation and tailoring; and implementation science constructs (ie, implementation, dissemination, adoption, scalability, feasibility, acceptability, sustainability, barriers and facilitators, community-based participatory research [CBPR], and fidelity).
After removing irrelevant articles, 320 records were obtained; this decreased to 296 unique records after removing 24 duplicates (Figure). A full-text review of 296 articles identified 69 sources that met the initial inclusion criteria. Because only sources reporting implementation data relevant to at least 1 RE-AIM domain were retained for the main analysis, this number was reduced to 37 (1,2,4–6,8,10–40) and organized in Zotero reference manager. Consistent with integrative review methodology (9), the 37 sources include empirical studies, study protocols with implementation detail, and reviews; some contributed data to multiple domains and are therefore represented as separate analytic units.
Figure. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 flow diagram for systematic literature search and study selection process. [A text description of this figure is available.]
All screening, data extraction, and quality appraisal were conducted by a single reviewer (R.N.) with expertise in diabetes management and implementation science, using standardized tools and procedures to minimize bias. Title and abstract screening were conducted systematically using predetermined inclusion criteria. Full-text review applied explicit decision rules documented in an extraction protocol. Detailed characteristics of all 37 included studies, including design, population, intervention type, cultural adaptation strategy, and key findings by RE-AIM domain, were tabulated.
Sample
Inclusion criteria were peer-reviewed sources that were published in English between 2005 and 2025, were conducted in the US, involved Hispanic/Latino adults (aged ≥18 y), addressed diabetes prevention interventions, reported cultural adaptation components, and reported data on 1 or more RE-AIM domains. Consistent with integrative review methodology, which permits synthesis of empirical and nonempirical literature (9), both primary sources (empirical studies) and secondary sources (study protocols, reviews, and program summaries) were eligible when they described implementation processes, barriers, or facilitators. Study designs included randomized controlled trials (RCTs), quasi-experimental studies, mixed-methods studies, qualitative studies, program evaluations, CBPR studies, and feasibility or pilot studies when reporting implementation outcomes. Early phase feasibility and proof-of-concept studies were retained when they reported implementation processes relevant to domains, despite limited outcome data.
Exclusion criteria were sources with no implementation content (including reviews, commentaries, and protocols that described only intervention efficacy), studies on pediatric populations, studies with no cultural adaptation, efficacy trials without implementation context, and non–peer-reviewed literature.
Measurements
All studies meeting initial inclusion criteria were appraised by using the Johns Hopkins Evidence-Based Practice appraisal tool, which evaluates the level and quality of evidence. Of the 69 sources screened, 37 were retained and rated level I through level III, with high (A) or good (B) methodological quality; these 37 sources formed the basis for the results synthesis. Empirical studies were appraised on their design; protocols, reviews, and summaries were appraised as level III nonexperimental evidence on the basis of the implementation detail they provided. Lower-quality studies that provided unique contextual or implementation insights were retained but weighted accordingly in interpretation. Standardized forms captured study characteristics, population characteristics, intervention characteristics, cultural adaptation strategies, and implementation data for each domain. Many studies provided data relevant to multiple domains; the primary domain each study explicitly addressed was documented, while the results synthesis incorporated all relevant data across domains.
Analytic strategy
Data analysis used constant comparative methods and thematic synthesis. The initial analysis organized findings from the 37 sources by domain. Within each domain, iterative coding identified patterns and themes. Implementation barriers and facilitators were categorized by using multilevel socioecological frameworks. Given substantial heterogeneity, narrative synthesis rather than meta-analysis was used.
Results
Study characteristics
Thirty-seven sources published from 2005 through 2025 informed the synthesis: 24 empirical studies (RCTs, quasi-experimental and pilot studies, and qualitative, observational, and mixed-methods studies), 6 study protocols with implementation detail, and 7 reviews or program summaries (Table 1). Sample sizes ranged from 21 to 143,000 participants, reflecting both intensive community-based feasibility studies and large-scale national program evaluations. Studies were geographically concentrated in regions with substantial Hispanic populations, particularly the Southwest (California, Texas, Arizona, New Mexico), with additional representation from Florida, Illinois, New York, and North Carolina. Approximately 44% of studies explicitly referenced implementation science frameworks or constructs. Methodological quality, assessed using the Johns Hopkins Evidence-Based Practice criteria, were rated either high or good (Table 2). All 37 studies contributed meaningfully to understanding the implementation of culturally tailored diabetes prevention across diverse Hispanic populations and settings.
Population characteristics
Mexican Americans were the most frequently represented subgroup across studies, followed by Puerto Ricans. Many studies reported participants as “Hispanic/Latino” without specifying their ethnic subgroup. Female participation averaged 78% (range, 65%–100%), with only 3 studies specifically studying men (25,30). Male participation ranged from 7% to 35% in mixed-sex studies, below population parity, despite Hispanic men experiencing comparable diabetes rates (1). Studies successfully reached high-risk populations: 64% enrolled low-income participants, 50% enrolled uninsured or Medicaid-insured participants, and 73% enrolled Spanish-speaking participants (22,29,38).
Table 3 provides a summary of facilitators, barriers, and notable outcomes across all 5 RE-AIM domains.
Reach: participation and representativeness
Of the studies, 18 provided data relevant to the reach outcomes. Among those reporting participation rates, enrollment ranged from 18% to 67% of eligible people, with a median of 43% (5,10,37). A large-scale NDPP implementation study encountered challenges: only 35.5% of enrolled participants completed the core requirements, with even lower completion rates among Hispanic participants (3). Rural Hispanic adults faced limited access due to fewer available sites, geographic distances, and transportation issues (10). A community-based program using intensive engagement strategies reported higher enrollment rates, ranging from 45% to 67%, despite serving smaller eligible populations (22).
Reach facilitators. Community-based recruitment through trusted venues (churches, community centers) proved most effective (75% of studies). Promotora-led recruitment leveraged community health workers’ shared cultural backgrounds and existing trust relationships (52% of studies), achieving higher enrollment than professional recruiters (22). CBPR approaches were commonly associated with improved cultural appropriateness (25% of studies). Culturally tailored recruitment materials featuring Spanish language, culturally relevant imagery, and messaging emphasizing family health resonated powerfully with Hispanic adults (68% of studies) (12). Family-based recruitment, leveraging familismo values and flexible, low-barrier approaches that accommodate work schedules and reduce administrative burden, improved participation (39% of studies) (13,15,33).
Reach barriers. Low prediabetes awareness and fatalistic beliefs about diabetes undermined prevention messages (n =12 studies, 32%), with patients unaware of their prediabetes status or unfamiliar with available prevention options (17,41). Language and health literacy barriers persisted even with Spanish-language offerings, as technical verbiage intimidated prospective participants (n = 17, 46%). Work schedule conflicts affected low-income hourly workers without flexible schedules (n = 19, 51%) (39). Transportation and childcare barriers prevented attendance, especially in rural areas (n = 14, 38%). Immigration concerns deterred participation among undocumented immigrants and mixed-status families (n = 7, 19%). Diabetes-related stigma affected enrollment decisions (n = 9, 24%). Sex-specific barriers for Hispanic men included programs that men felt were designed for women, work inflexibility, discomfort with group settings, and cultural expectations of masculine self-sufficiency (n = 6, 16%). Digital access barriers limited the use of technology-delivered interventions among low-income participants (n = 8, 22%).
Effectiveness: real-world outcomes
Community-based interventions produced clinically meaningful weight loss averaging 3.2 kg to 5.8 kg, body mass index reductions of 1.1 kg/m2 to 2.3 kg/m2, reductions in waist circumference of 3.4 cm to 7.1 cm, and reductions in hemoglobin A1C of 0.2 to 0.6 percentage points (26,40). These real-world effect sizes were smaller than those in the original Diabetes Prevention Program (DPP) efficacy trial but were clinically significant (34). Dietary and physical activity improvements were substantial (21), with participants reporting sustained adoption of healthier practices culturally adapted to Hispanic preferences, including remotely delivered plant-based culinary programs that demonstrated feasibility and cultural acceptability among Hispanic adults (19,42). Participant satisfaction ratings were high (85%–95%) (36).
Implementation context effects. A community-based setting achieved outcomes comparable to or exceeding clinical settings while achieving higher levels of engagement (26). A promotora-led intervention reached results comparable to professional-led interventions while improving cultural acceptability and cost-effectiveness (22). Per NDPP data, dose–response relationships underscored retention’s importance: participants completing 9 or more of 16 NDPP sessions achieved 2 to 3 times more weight loss than those attending fewer sessions (3). Interventions using multiple cultural adaptation strategies achieved superior outcomes compared with single-strategy adaptations (31,40).
Adoption: organizational settings and delivery personnel
Twenty-seven studies provided data on organizational adoption. Community-based organizations were the most common adopters, offering trusted venues and cultural concordance, although resource constraints were typical. Faith-based organizations (33%) successfully adopted programs by leveraging social networks and trusted religious leaders but faced challenges with volunteer-dependent delivery. Primary care clinics and federally qualified health centers (26%) integrated programs but faced capacity constraints and competing priorities (11,28). Workplace (7%) and educational settings (4%) showed promise but faced sustainability challenges,
Delivery personnel varied across studies: community health workers/promotoras (52%) brought shared cultural backgrounds and community trust but faced recruitment challenges and limited career pathways; professional health educators (26%) provided clinical expertise but with limited bilingual/bicultural availability; hybrid models (15%), which partnered promotoras with professionals, optimized cultural responsiveness and clinical quality.
Adoption facilitators. Mission alignment with health equity (33% of studies), existing community relationships (43%), leadership support (22%), bilingual/bicultural staff characteristics (26%), external technical assistance (19%), and funding availability (41%) facilitated organizational adoption.
Adoption barriers. Resource constraints, including limited staff capacity and inadequate funding (37%), lack of a bicultural workforce (27%), organizational readiness gaps (15%), competing priorities (19%), sustainability concerns about time-limited grants (26%), and adaptation-fidelity tensions related to Centers for Disease Control and Prevention recognition requirements (11%), impeded adoption.
Implementation
Implementation success across studies was linked to cultural concordance and to predominantly bilingual/bicultural staff serving as trusted cultural brokers (22). One program delivered in trusted community settings reduced structural barriers and increased acceptability (35). CBPR approaches strengthened recruitment and supported adaptation without compromising core components (31). Flexibility accommodating work schedules, caregiving responsibilities, and transportation constraints improved attendance and retention (14).
Implementation barriers identified across studies included limited time-bound funding, which constrained staffing and continuity; bicultural personnel shortages, which impeded scalability; digital literacy gaps, which challenged remotely delivered interventions (18); and insufficient leadership buy-in, which complicated implementation in health care systems (2,24).
Maintenance
Maintenance was the least consistently examined domain, with only 1 analytical study (40) clearly treating it as a primary focus, although several others provided maintenance-related insights. Only 18% of studies reported outcomes beyond 12 months. Sustainability was closely linked to integration within existing health care infrastructures rather than to stand-alone, grant-funded initiatives (2). Programs integrated into primary care or community health organizations demonstrated greater continuity than those dependent on short-term external funding.
At the individual level, sustained behavior change was supported by family involvement, peer support, and ongoing group interaction (20,23). Institutional ownership, reimbursement mechanisms, and workforce stability facilitated organizational sustainability. Programs aligned with NDPP reimbursement pathways were more likely to persist (40). Few studies reported cost-effectiveness analyses or formal sustainability plans, limiting assessment of long-term feasibility (40).
Discussion
This integrative review of 37 studies showed that culturally tailored diabetes prevention interventions for Hispanic adults are effective at reducing diabetes risk; however, their translation into sustained real-world practice is uneven. Applying the RE-AIM framework showed that, while reach and effectiveness are well documented, adoption, implementation, and maintenance lag, limiting population-level impact.
Interventions grounded in cultural concordance, community partnerships, and flexible delivery showed stronger implementation outcomes than clinic-based or technology-driven models alone (16,35). Promotora-led and family-centered approaches effectively fostered trust, relevance, and engagement, underscoring the importance of relational and culturally embedded strategies (43). However, persistent gaps, including male underrepresentation, workforce shortages, and sustainability limitations, underscore the need for intentional implementation planning that addresses structural barriers alongside intervention design.
The persistent gap between reach/effectiveness and the downstream domains of adoption, implementation, and maintenance reflects well-documented patterns in implementation science; interventions that demonstrate efficacy under controlled conditions frequently encounter structural, organizational, and resource barriers that impede real-world translation. Community-based organizations, while culturally aligned, frequently lack the infrastructure, reimbursement mechanisms, and workforce stability to sustain programming beyond initial grant periods, a phenomenon consistent with the implementation outcomes framework by Proctor et al, which identifies sustainability as the most distal and difficult-to-achieve implementation outcome (44).
Moreover, community partnerships improve implementation outcomes by reducing the structural distance between intervention design and the delivery context, facilitating real-time adaptation without compromising core components, a process that Glasgow et al describe as “fit” within the RE-AIM framework (7). Flexible delivery accommodates the lived realities of low-income, hourly-wage, and caregiving populations for whom rigid scheduling constitutes a participation barrier independent of intervention quality (2).
Promotora-led models are effective because promotoras serve as cultural and epistemological agents, people who share the participants’ language, cultural frameworks, and social contexts and who, therefore, communicate health information through culturally resonant meaning systems (22). Family-centered approaches leverage familismo, a core Hispanic cultural value emphasizing collective family identity and interdependence, thereby transforming behavior change from an individual responsibility into a shared family commitment, a reframing that reduces stigma and increases social accountability (44). The qualitative review by Sanders Thompson et al similarly identified culturally grounded theoretical frameworks as essential to intervention engagement and retention among Hispanic adults (43).
Implications for public health practice
Translating evidence-based diabetes prevention into sustainable community practice requires strategic implementation that addresses multilevel barriers (27). Community-based organizations demonstrated strong cultural alignment and trust but faced resource constraints that threatened continuity. Health care and public health workforces are well positioned to operationalize culturally tailored prevention strategies through partnerships with trusted community organizations, including faith-based settings (45), flexible delivery models that reduce structural barriers to participation, and the integration of cultural humility and language concordance into service delivery.
Addressing upstream factors, including stigma, gender norms, health literacy, and social determinants, is essential to improving reach and engagement. Persistent underrepresentation of Hispanic men across studies underscores the need for targeted outreach, including workplace-based programs, male-specific messaging, and interventions that address cultural expectations of masculine self-sufficiency. Rural communities face compounded access barriers related to geographic distance, transportation, and limited program availability, necessitating deliberate strategies such as telehealth adaptation, mobile delivery, and regional coordination.
The success of promotora-led models underscores the value of leveraging community health workers’ shared cultural backgrounds, existing trust relationships, and community embeddedness. However, workforce development must address recruitment challenges, limited career pathways, and the need for ongoing training and support. Hybrid models that pair community health workers with professional health educators optimize both cultural responsiveness and clinical quality while expanding workforce capacity.
Implications for policy and systems
Sustainable diabetes prevention requires structural support that extends beyond time-limited grant funding. Policy priorities include reimbursement for community health workers and promotoras, investment in bicultural workforce development, and incentives for health care–community partnerships (1,2). Without policy alignment, culturally tailored interventions risk remaining fragmented, short-term, and grant-dependent rather than embedded in health care and public health systems.
Integration into existing health care infrastructures demonstrated greater continuity than stand-alone initiatives. Programs aligned with NDPP reimbursement pathways were more likely to persist (40). Policy support for prevention services, workforce development, and health care–community integration is essential to achieving equitable access and sustained impact. Policies that address social determinants of health, which include immigration concerns, transportation barriers, childcare access, and inflexible work schedules, can reduce structural barriers that limit participation among populations at high risk of poor health outcomes.
Implications for the workforce
Implementation success depends on a culturally concordant, well-trained, and sustainably employed workforce. Findings from studies underline the need to equip public health and health care professionals with competencies in cultural adaptation, community-based participatory approaches, and implementation science frameworks. Educational programs should emphasize partnership development, health equity advocacy, and systems thinking to address multilevel barriers to diabetes prevention.
Public health workers, particularly those in community and public health settings, play essential roles in bridging evidence, culture, and community context. Their population-focused lens helps identify groups requiring targeted outreach, and their competencies in cultural humility, trust-building, and addressing social determinants position them to lead implementation efforts. However, successful workforce development extends beyond individual competencies to include career pathways for community health workers, continuing education and technical assistance, and organizational support for implementation fidelity and adaptation (2).
Integrating RE-AIM and similar implementation frameworks into workforce development strengthens the capacity to translate evidence-based interventions into equitable, sustainable community practice. Workforce planning must address bilingual/bicultural personnel shortages, which have emerged as a persistent implementation barrier to scalability and adoption across diverse settings (24).
Recommendations for future research
Research priorities that emerged from the synthesis of 37 studies include comparative implementation trials that identify which strategies work best in specific contexts (45), long-term maintenance studies extending beyond 12 months, cost-effectiveness analyses to inform sustainability decisions, tailored strategies to engage Hispanic men and underrepresented subgroups, and hybrid effectiveness–implementation designs that advance equitable, scalable prevention (27,40).
Inconsistent reporting of implementation outcomes, predominantly in the adoption and maintenance domains, limits evidence synthesis and cross-study comparisons. Future research should systematically measure and report RE-AIM outcomes using standardized metrics to strengthen the evidence base for implementation decision-making. Research examining workforce contributions to diabetes prevention implementation would inform workforce planning and educational preparation.
Limitations
Although comprehensive, the review had several limitations. These articles were limited to English-language studies conducted in the US, potentially excluding relevant international perspectives. The variability in study designs, intervention components, and outcome reporting across the 37 studies limited direct comparisons. Implementation outcomes were inconsistently reported, particularly in the adoption and maintenance domains, with only 2 studies examining maintenance beyond 12 months. The inclusion of study protocols and reviews alongside empirical studies broadened the implementation evidence but means that not all sources contributed outcome data; effectiveness findings are drawn from the empirical studies only.
Despite an equity focus, some studies may have excluded structurally marginalized people, including people who are undocumented or those with unstable housing. Persistent male underrepresentation limits generalizability to Hispanic men. Furthermore, quality appraisal and data extraction were conducted by a single reviewer, which is a methodological limitation. Although standardized Johns Hopkins Evidence-Based Practice criteria were applied consistently and the reviewer has expertise in diabetes and implementation science, the absence of a second independent appraiser increases the risk of bias and limits the confirmability of quality ratings. Future reviews should incorporate dual reviewers and inter-rater reliability calculations to strengthen methodological rigor.
Conclusion
This integrative review demonstrates that culturally tailored diabetes prevention interventions for Hispanic adults are effective, acceptable, and culturally resonant. Yet, their real-world impact is limited by implementation and sustainability challenges. The application of the RE-AIM framework to analyze 37 primary research studies indicated gaps beyond effectiveness, particularly in adoption, implementation, and maintenance, which hinders equitable benefits at the population level.
Evidence from studies supports cultural concordance, community-based delivery, promotora models, and family-centered approaches as foundational to successful diabetes prevention in Hispanic populations. However, persistent barriers that include workforce limitations, funding instability, male underrepresentation, and limited maintenance data highlight the need for intentional implementation planning and sustainability-focused research.
Advancing equitable diabetes prevention requires coordinated efforts across practice, education, research, and policy to ensure that interventions are culturally tailored, accessible, scalable, and sustainable. Addressing structural inequities through workforce development, sustainable funding mechanisms, and health care–community partnerships is essential to translating evidence into population-level impact.
Acknowledgments
The author thanks the PhD faculty at Texas Woman’s University for their mentorship in nursing scholarship, as well as the colleagues and mentors who provided guidance and support during the development of this integrative review.
The author declares no potential conflicts of interest with respect to the research, authorship, and publication of this article. The author received no external financial support for the research, authorship, or publication of this article. This research received no specific grant from any funding agency in the public, commercial, or nonprofit sectors. No copyrighted material, surveys, instruments, or tools were used in the research described in this article. This integrative review analyzed published literature and did not involve human participants. Ethical approval was not required. Data extraction forms and analysis materials are available from the corresponding author upon reasonable request.
Author Information
Corresponding Author: Rachell Nguyen, DNP, APRN, Texas Woman’s University College of Nursing, 6700 Fannin St, Houston, TX 77030 (rnguyen8@twu.edu).
Author Affiliations: 1Texas Woman’s University College of Nursing, Houston, Texas.
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Tables
| Study author (year) | Study design | Sample/setting | RE-AIM domain(s) informed | JHNEBP levelb | Quality (A–C)c | Key strengths | Key limitations |
|---|---|---|---|---|---|---|---|
| Ariel-Donges et al (10), 2020 | Observational | Rural/urban NDPP | Reach | III | B | Access disparities | Descriptive |
| Balan et al (11), 2025 | Program evaluation | Hispanic women | Adoption | V | B | Equity emphasis | Executive summary |
| Brown et al (12), 2018 | Qualitative | Mexican American adults | Implementation | III | B | Rich participant voice | No outcomes |
| Burd et al (2), 2020 | Policy implementation | Medicare NDPP | Adoption | III | B | System-level insight | No individual outcomes |
| Cranston et al (13), 2025 | Community evaluation | Inclusive DPP | Implementation | III | B | Equity-driven | Localized |
| Dineen et al (6), 2022 | Qualitative | Community sites | Implementation | III | B | Implementation depth | No outcomes |
| Fontil et al (14), 2016 | Pilot feasibility | Low-income Hispanic adults | Implementation | II | B | Digital adaptation | Short follow-up |
| Franklin et al (15), 2025 | Study protocol | Hispanic adults | Implementation | NA | NA | Family-centered | Early phase |
| Gutierrez Chavez et al (4), 2025 | Qualitative | NDPP coaches | Implementation | III | B | Cultural delivery | Small sample |
| Horowitz et al (16), 2011 | Mixed methods | Community-based intervention | Reach, implementation | III | B | Strong CBPR approach | Limited control |
| Johnston et al (5), 2025 | Scoping review | NDPP reach | Reach | V | B | Comprehensive | Secondary data |
| Joiner et al (17), 2025 | Qualitative | Hispanic adults | Reach | III | B | Awareness focus | No intervention |
| Joseph (1), 2023 | Narrative review | Minority populations | Adoption | V | B | Equity framing | Broad scope |
| Kim et al (18), 2018 | Study protocol | Medicaid population | Implementation | NA | NA | Real-world context | Selection bias |
| Koh (19), 2023 | Integrative review | Hispanic adults | Effectiveness | V | B | Nutrition focus | Dietary self-report |
| Ling et al (20), 2023 | Narrative review | Minority adults | Implementation | V | B | Peer support | Limited Hispanic-only data |
| Loya et al (21), 2025 | Pilot feasibility | Hispanic adults | Effectiveness | II | B | Physical activity focus | Small sample |
| McCurley et al (22), 2017 | Pilot trial | Latina women | Effectiveness | II | B | Cultural relevance | Small sample |
| McCurley et al (8), 2017 | Systematic review | Hispanic adults | Effectiveness | II | A | Strong synthesis | Not implementation-focused |
| McEwen et al (23), 2010 | Intervention trial | Border populations | Effectiveness | II | B | Social support | Older model |
| Meulenberg et al (24), 2025 | Survey | NDPP participants | Adoption | III | B | Barrier analysis | Self-report |
| Miranda et al (25), 2025 | Qualitative | Mexican-origin men | Reach | III | B | Cultural narratives | Gender-specific |
| Ockene et al (26), 2012 | RCT | Latino community adults | Effectiveness | I | A | Randomization, objective outcomes | Single region |
| Patel et al (27), 2025 | Scoping review | Population level | Adoption | V | A | Multilevel lens | Heterogeneous data |
| Risica et al (28), 2018 | Study protocol | Latino adults | Implementation | NA | NA | Program rationale | Outcomes pending |
| Rosas et al (29), 2016 | Study protocol: RCT | Primary care Latino adults | Effectiveness | NA | NA | Rigorous design | Clinic-based only |
| Rosas et al (30), 2018 | Study protocol: RCT | Latino men | Effectiveness | NA | NA | Male engagement | Gender-specific |
| Rosas et al (31), 2018 | Program description | Latino adults | Adoption | V | B | Patient engagement | Limited follow-up |
| Rosas et al (32), 2024 | Study protocol: RCT | Latina women | Effectiveness | NA | NA | Innovative groceries | Resource intensive |
| Sanchez et al (33), 2022 | Qualitative | Latinx families | Reach | III | B | Family dynamics | Regional |
| Saju et al (34), 2022 | Qualitative | Diverse adults | Reach | III | B | Equity focus | Recall bias |
| Soltero et al (2019) (35), 2019 | Multilevel intervention | Community settings | Adoption | I | A | Multisector model | Complex replication |
| Vincent et al (36), 2007 | Feasibility | Mexican American adults | Implementation | II | B | Early cultural tailoring | Dated context |
| Vincent et al (2013) (37), 2013 | Mixed methods | Mexican-descent adults | Reach, implementation | III | B | Recruitment/retention focus | Small sample |
| Vincent et al (38), 2014 | Quasi-experimental | Community based | Effectiveness | II | B | Cultural tailoring | No randomization |
| Joachim-Célestin et al (39), 2020 | Qualitative | Latina participants | Reach, implementation | III | B | Cultural insight | Subjective data |
| Lewis et al (40), 2025 | Longitudinal qualitative | Vida Sana | Maintenance | III | B | Sustainability insight | Qualitative only |
Abbreviations: DPP, diabetes prevention program; JHNEBP, Johns Hopkins Evidence-Based Practice; NA, not applicable; NDPP, National Diabetes Prevention Program; RCT, randomized controlled trial; RE-AIM, Reach, Effectiveness, Adoption, Implementation, and Maintenance.
a This table summarizes the methodological quality appraisal of the 37 sources (empirical studies, study protocols, and reviews) included in the integrative review, using the JHNEBP appraisal tool.
b Level I, experimental/RCT; Level II, quasi-experimental; Level III, nonexperimental, qualitative, mixed methods.
c A indicates high quality, B indicates good quality, and C indicates low quality.
| Study author (year) | Study design | Sample population | Setting | Intervention type | Cultural adaptation strategy | Analytic approach | Key barriers | Key facilitators | RE-AIM domain(s) |
|---|---|---|---|---|---|---|---|---|---|
| Ariel-Donges et al (10), 2020 | Observational | Rural/urban NDPP participants | Rural and urban US communities | NDPP access comparison | Geographic access analysis | Descriptive/comparative analysis | Fewer rural sites; transportation; geographic distance | Identification of access disparities to inform targeted outreach | Reach |
| Balan et al (11), 2025 | Program evaluation | Hispanic women | Community/health system settings | Diabetes prevention program evaluation | Equity-focused program design for Black and Hispanic women | Executive summary/synthesis of lessons learned | Resource constraints; need for tailored strategies | Equity-driven program design; actionable lessons learned | Adoption |
| Brown et al (12), 2018 | Qualitative | Mexican American adults (Starr County) | Border community (Starr County, TX) | Diabetes prevention focus groups | Community-based, border-region cultural framing | Thematic/qualitative analysis of focus groups | Limited program availability; no quantitative outcomes | Rich participant voice on cultural perceptions and needs | Implementation |
| Burd et al (2), 2020 | Policy implementation | Medicare NDPP beneficiaries (national) | Medicare program/national health system | Medicare expansion of NDPP lifestyle intervention | National program adaptation for diverse populations | Policy/translational analysis | No individual-level outcomes; system-level barriers to uptake | System-level insight; reimbursement pathway model | Adoption |
| Cranston et al (13), 2025 | Community evaluation | Inclusive DPP participants | Community-based DPP sites | Inclusive DPP | Equity-driven program adaptations for inclusion | Program evaluation/descriptive analysis | Localized findings; limited generalizability | Equity-driven approach to inclusive program design | Implementation |
| Dineen et al (6), 2022 | Qualitative | Community site staff/participants | 2 Community-based DPP sites | DPP implementation | Community site–based delivery adaptation | Qualitative implementation analysis | No outcome data; site-specific findings | Implementation depth; site-level insights | Implementation |
| Fontil et al (14), 2016 | Pilot feasibility | Low-income Hispanic adults | Safety-net hospital system + digital health partner | Digital health diabetes prevention program | Digital adaptation for low-income, Spanish-speaking patients | Feasibility analysis | Short follow-up; digital literacy gaps | Digital adaptation feasible in safety-net setting | Implementation |
| Franklin et al (15), 2025 | Study protocol | Hispanic/Latino adults at high risk for type 2 diabetes | Community/family setting | PrevenganT2 family-based diabetes prevention intervention | Family-based, culturally responsive program design | Proof-of-concept/feasibility analysis | Early-phase program; limited outcome data | Family-centered design promotes engagement | Implementation |
| Gutierrez Chavez et al (4), 2025 | Qualitative | NDPP coaches | NDPP delivery sites | NDPP delivery (coach perspective) | Culturally responsive coaching strategies | Qualitative thematic analysis | Small sample size | Cultural delivery strategies identified by coaches | Implementation |
| Horowitz et al (16), 2011 | Mixed methods | Community-based intervention participants | Historically underserved urban community | Community-based diabetes prevention translation model | CBPR-driven community partnership model | Mixed methods (quantitative outcomes + qualitative process) | Limited experimental control | Strong CBPR approach; successful translation model | Reach, Implementation |
| Johnston et al (5), 2025 | Scoping review | NDPP participants (secondary data) | NDPP sites | NDPP reach analysis | Secondary analysis of reach across populations | Secondary/observational data analysis | Secondary data limitations | Comprehensive national reach data | Reach |
| Joiner et al (17), 2025 | Qualitative | Hispanic adults with prediabetes risk | Community settings | Prediabetes awareness exploration (no intervention) | Culturally grounded awareness framing | Qualitative thematic analysis | Low prediabetes awareness; fatalistic beliefs | Awareness-focused insights to inform recruitment messaging | Reach |
| Joseph (1), 2023 | Narrative review | Minority populations (national) | US health system/policy context | Diabetes prevention, treatment, and outcomes equity review | Equity-focused framing across diabetes care continuum | Translational/narrative synthesis | Broad scope limits specificity | Equity framing applicable across implementation domains | Adoption |
| Kim et al (18), 2018 | Study protocol | Medicaid population | Digital diabetes prevention program (Medicaid) | Digital DPP adapted for Medicaid population | Adaptation for low-income/Medicaid-insured population | Nonrandomized comparative analysis | Selection bias; nonrandomized design | Real-world implementation context for underserved population | Implementation |
| Koh (19), 2023 | Integrative review | Hispanic/Latino adults | Community-based nutrition program | Plant-based nutrition intervention | Culturally tailored plant-based dietary adaptation | Pre/post outcome analysis | Reliance on dietary self-report | Nutrition-focused cultural tailoring | Effectiveness |
| Ling et al (20), 2023 | Narrative review | Minority adults (diabetes prevention) | Community-based peer support program | Peer-support intervention for diabetes prevention | Peer-led culturally relevant support model | Synthesis/comparative analysis | Limited Hispanic-specific data | Peer support enhances engagement and retention | Implementation |
| Loya et al (21), 2025 | Pilot feasibility | Hispanic adults | Community-based physical activity program | Culturally tailored physical activity intervention | Culturally adapted physical activity programming | Pilot/feasibility pre/post analysis | Small sample size | Physical activity focus shows feasibility and acceptability | Effectiveness |
| McCurley et al (22), 2017 | Pilot trial | Latina women | Primary care + community (Nuevo Amanecer-II) | Nuevo Amanecer-II culturally appropriate DPP | Promotora-led, Spanish-language, family-involved adaptation | Pilot pre/post analysis | Small sample size | Cultural relevance and promotora delivery model | Effectiveness |
| McCurley et al (8), 2017 | Systematic review | Hispanic adults | Multiple community/clinical settings | Synthesis of culturally tailored DPP interventions | Synthesis of multiple cultural adaptation strategies | Systematic synthesis/narrative review | Not implementation-focused | Strong synthesis of effective adaptation strategies | Effectiveness |
| McEwen et al (23), 2010 | Intervention trial | US–Mexico border populations | Border community health setting | Type 2 diabetes self-management social support intervention | Border-region, family/peer social support model | Pre/post intervention analysis | Older program model; limited generalizability | Social support drives sustained behavior change | Effectiveness |
| Meulenberg et al (24), 2025 | Survey | NDPP lifestyle coaches (Latino-serving) | NDPP delivery sites serving Latino participants | NDPP delivery (coach-reported barriers/facilitators) | Coach-identified cultural adaptation needs | Survey/descriptive analysis | Self-report bias; coach-identified resource barriers | Barrier analysis informs workforce/training needs | Adoption |
| Miranda et al (25), 2025 | Qualitative | Mexican-origin men | Community settings | Nutrition/health discussion using cultural dichos | Use of culturally rooted sayings (dichos) for health messaging | Qualitative thematic analysis | Gender-specific findings limit generalizability | Cultural narratives (dichos) enhance engagement among men | Reach |
| Ockene et al (26), 2012 | RCT | Latino community adults (Lawrence, MA) | Community-based (Lawrence Latino Diabetes Prevention Project) | Community-based DPP-adapted lifestyle intervention | Spanish-language, community-delivered cultural adaptation | RCT with objective outcome measures | Single-region sample limits generalizability | Randomized design with community-based delivery success | Effectiveness |
| Patel et al (27), 2025 | Scoping review | Population-level (multilevel interventions) | Multilevel settings | Multilevel diabetes prevention interventions | Multilevel cultural and contextual adaptation | Scoping/mixed-methods synthesis | Heterogeneous data across contexts | Multilevel lens applicable to adoption strategies | Adoption |
| Risica et al (28), 2018 | Study protocol | Latino adults | Community clinic-based program | Vida Saludable/Healthy Life lifestyle change program | Community clinic–based cultural tailoring | Pilot methods/protocol-level analysis | Outcomes pending at time of publication | Clear program rationale and clinic-based delivery model | Implementation |
| Rosas et al (29), 2016 | Study protocol: RCT | Primary care Latino adults | Primary care setting (Vida Sana) | Culturally adapted lifestyle intervention (Vida Sana) | Culturally adapted lifestyle program for cardiometabolic risk | RCT with rigorous outcome evaluation | Clinic-based delivery only | Rigorous design demonstrates effectiveness in primary care | Effectiveness |
| Rosas et al (30), 2018 | Study protocol: RCT | Latino men (HOMBRE trial) | Community/clinical settings | HOMBRE intervention for obesity and prediabetes | Male-targeted culturally tailored intervention | RCT outcome analysis | Gender-specific design limits broader generalizability | Male engagement model addresses underrepresentation | Effectiveness |
| Rosas et al (31), 2018 | Program description | Latino adults | Patient-centered care setting (Vida Sana) | Patient-centered diabetes prevention and weight loss approach | Patient-centered cultural tailoring | Patient-centered outcome analysis | Limited follow-up duration | Strong patient engagement and acceptability | Adoption |
| Rosas et al (32), 2024 | Study protocol: RCT | Latina women (Vida Sana y Completa) | Primary care setting | Vida Sana y Completa culturally adapted DPP with grocery component | Innovative grocery/food-access cultural adaptation | RCT protocol-based outcome analysis | Resource-intensive intervention model | Innovative grocery-based component supports adherence | Effectiveness |
| Sanchez et al (33), 2022 | Qualitative | Latinx families | Community/family settings | Healthy living facilitators/barriers exploration | Family-centered cultural framing (familismo) | Qualitative thematic analysis | Regional sample limits generalizability | Family dynamics identified as key facilitator | Reach |
| Saju et al (34), 2022 | Qualitative | Diverse adults (including Hispanic/Latino) in lifestyle program | Community-based lifestyle intervention sites | Lifestyle intervention weight-loss program | Equity-focused exploration of race/ethnicity differences | Qualitative/comparative analysis | Recall bias in self-reported data | Equity focus highlights differential outcomes by group | Reach |
| Soltero et al (35), 2019 | Multilevel intervention | Adults of Mexican descent (Maryvale community) | Multisector community settings (Viva Maryvale) | Community- and multi-level physical activity intervention | Multi-level, multi-sector cultural and environmental adaptation | Multilevel program evaluation | Complex model difficult to replicate | Multisector model demonstrates strong adoption pathway | Adoption |
| Vincent et al (36), 2007 | Feasibility | Mexican Americans | Community-based setting | Early culturally tailored diabetes prevention intervention | Early-stage cultural tailoring for Mexican American adults | Feasibility analysis | Dated context; limited modern applicability | Early cultural tailoring established foundational model | Implementation |
| Vincent et al (37), 2013 | Mixed methods | Adults of Mexican descent | Community-based program | Culturally tailored diabetes prevention program (recruitment/retention focus) | Recruitment/retention-focused cultural strategies | Mixed-methods recruitment/retention analysis | Small sample size | Recruitment and retention strategies identified | Reach, Implementation |
| Vincent et al (38), 2014 | Quasi-experimental | Community-based adults of Mexican descent | Community-based setting | Community-based culturally tailored diabetes prevention intervention | Community-based cultural tailoring for high-risk adults | Quasi-experimental pre/post analysis | No randomization | Cultural tailoring associated with positive outcomes | Effectiveness |
| Joachim-Célestin et al (39), 2020 | Qualitative | Latina participants (DPP enrollees) | Diabetes prevention program setting | Diabetes prevention program (participant perspective) | Exploration of Latina cultural perspectives on DPP enrollment | Qualitative thematic analysis | Subjective, self-reported data | Cultural insight into participant experience and motivation | Reach, Implementation |
| Lewis et al (40), 2025 | Longitudinal qualitative | Vida Sana participants | Primary care/community setting | Vida Sana culturally adapted lifestyle program evaluated via RE-AIM framework | Long-term cultural adaptation sustainability strategies | Longitudinal qualitative analysis | Qualitative-only data limits generalizability | Sustainability insight from long-term participant follow-up | Maintenance |
Abbreviations: CBPR, community-based participatory research; DPP, diabetes prevention program; NDPP, National Diabetes Prevention Program; RCT, randomized controlled trial; RE-AIM, Reach, Effectiveness, Adoption, Implementation, and Maintenance.
| RE-AIM domain | No. of studies reporting | Key facilitators | Key barriers | Notable outcomes |
|---|---|---|---|---|
| Reach | 18 | Community-based recruitment via trusted venues (75%); promotora-led recruitment (52%); culturally tailored materials/messaging (68%); family-based, familismo-oriented recruitment (39%); CBPR approaches (25%) | Low prediabetes awareness and fatalism (n = 12, 32%); language/health literacy barriers (n = 17, 46%); work schedule conflicts (n = 19, 51%); transportation/childcare barriers (n = 14, 38%); immigration concerns (n = 7, 19%); diabetes stigma (n = 9, 24%); gender-specific barriers for men (n = 6, 16%); digital access barriers (n = 8, 22%) | Enrollment ranged from 18% to 67% of eligible people (median, 43%); community-based intensive engagement achieved 45% to 67% enrollment; NDPP completion was 35.5%, with lower completion among Hispanic participants |
| Effectiveness | 36 | Cultural concordance; multiple (vs single) cultural adaptation strategies; promotora-led delivery comparable to professional-led delivery; community-based settings matched or exceeded clinical settings | Real-world effect sizes were smaller than those reported in the original DPP efficacy trial; heterogeneity in outcome reporting across studies | Weight loss, 3.2 kg to 5.8 kg; BMI reduction, 1.1 kg/m2 to 2.3 kg/m2; waist circumference reduction, 3.4 cm to 7.1 cm; HbA1C reduction, 0.2 to 0.6 percentage points; participant satisfaction, 85% to 95%; attending 9 or more of 16 NDPP sessions was associated with 2 to 3 times more weight loss |
| Adoption | 27 | Mission alignment with health equity (33%); existing community relationships (43%); leadership support (22%); bilingual/bicultural staff (26%); external technical assistance (19%); funding availability (41%) | Resource constraints/inadequate funding (37%); lack of bicultural workforce (27%); organizational readiness gaps (15%); competing priorities (19%); sustainability concerns related to time-limited grants (26%); adaptation–fidelity tensions associated with CDC recognition requirements (11%) | Community-based organizations were the most common adopters; other adopting settings were faith-based organizations (33%), primary care clinics/FQHCs (26%), workplaces (7%), and educational settings (4%). Programs were delivered by CHWs/promotoras (52%), professional health educators (26%), or hybrid promotora–professional teams (15%). |
| Implementation | Multiple (cross-domain) | Cultural concordance and bilingual/bicultural staff as trusted cultural brokers; community-based delivery settings; CBPR approaches supporting adaptation without compromising fidelity; flexible scheduling accommodating work, caregiving, and transportation constraints | Limited time-bound funding constrained staffing and continuity; bicultural personnel shortages impeded scalability; digital literacy gaps challenged remote delivery; insufficient leadership buy-in within healthcare systems | Promotora-led interventions achieved cultural acceptability and cost-effectiveness comparable to professional-led models; CBPR strengthened recruitment and adaptation |
| Maintenance | 1 (Primary focus); several others contributing related insights | Integration within existing health care infrastructure; institutional ownership; reimbursement mechanisms (eg, NDPP alignment); workforce stability; family involvement, peer support, and ongoing group interaction | Only 18% of studies reported outcomes beyond 12 months; sustainability was undermined by reliance on stand-alone, grant-funded initiatives; few studies included cost-effectiveness analyses or formal sustainability plans | Programs integrated into primary care and community health organizations demonstrated greater continuity than externally funded stand-alone programs; NDPP reimbursement-aligned programs were more likely to be sustained |
Abbreviations: BMI, body mass index; CBPR, community-based participatory research; CDC, Centers for Disease Control and Prevention; CHW, community health worker; FQHC, federally qualified health center; HbA1c, hemoglobin A1c; NDPP, National Diabetes Prevention Program; RE-AIM, Reach, Effectiveness, Adoption, Implementation, and Maintenance.
a Percentages are calculated on all 37 included sources; some sources contributed data to more than 1 domain.
The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors’ affiliated institutions.
