Supplemental Report
Perinatal Hepatitis B Prevention Program Data
Outcome data on infants born to persons with hepatitis B virus infection are reported by the CDC Perinatal Hepatitis B Prevention Program (PHBPP)(1), which funds 64 jurisdictions to identify pregnant persons infected with hepatitis B virus and to case-manage their infants to improve receipt of post-exposure prophylaxis (hepatitis B vaccine birth dose and hepatitis B immune globulin), hepatitis B vaccine series completion, and post-vaccination serologic testing. Participating jurisdictions are the 50 US states, District of Columbia, 5 cities (Chicago, Houston, New York City, Philadelphia, and San Antonio), 5 territories (American Samoa, Guam, N. Mariana Islands, Puerto Rico, U.S. Virgin Islands), and 3 freely associated island nations (Federated States of Micronesia, Republic of the Marshall Islands, Republic of Palau). Data in this report are from the reporting period for the 2018 birth cohort, followed from January 1, 2018 through December 31, 2019 and only include infants managed by the program. Infants have variable lengths of follow-up time depending on their date of birth. Not all infants identified as HBsAg positive are reported to the CDC National Notifiable Diseases Surveillance System (NNDSS). (https://www.cdc.gov/vaccines/programs/perinatal-hepb/index.html
- National Perinatal Hepatitis B Prevention Program: 2009–2017. Koneru A, Fenlon N, Schillie S, et al. Pediatrics March 2021, 147 (3) e20201823; DOI: https://doi.org/10.1542/peds.2020-1823external icon.
| Hepatitis B vaccine administration | Post-vaccination serologic testing | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Grantee | All infants managed | HBIG & vaccine at birth | Complete series by 12 months of age | Complete series after 12 months of age | Total with complete series | Received† | HBsAg positive | Immune§ | |||||||
| No. | No. | % | No. | % | No. | % | No. | % | No. | % | No. | % ¶ | No. | % ¶ | |
| All Jurisdictions | 9,950 | 9,617 | 97% | 8,609 | 87% | 129 | 1% | 8,738 | 88% | 6,828 | 69% | 23 | 0% | 6,547 | 96% |
| State | |||||||||||||||
| Alabama | 61 | 60 | 98% | 58 | 95% | 0 | 0% | 58 | 95% | 52 | 85% | 1 | 2% | 48 | 92% |
| Alaska | 31 | 30 | 97% | 23 | 74% | 0 | 0% | 23 | 74% | 19 | 61% | 1 | 5% | 18 | 95% |
| Arizona | 120 | 112 | 93% | 103 | 86% | 7 | 6% | 110 | 92% | 67 | 56% | 0 | 0% | 64 | 96% |
| Arkansas | 61 | 60 | 98% | 59 | 97% | 0 | 0% | 59 | 97% | 53 | 87% | 1 | 2% | 50 | 94% |
| California | 1,739 | 1,700 | 98% | 1316 | 76% | 7 | 0% | 1,323 | 76% | 983 | 57% | 3 | 0% | 940 | 96% |
| Colorado | 131 | 130 | 99% | 128 | 98% | 1 | 1% | 129 | 98% | 113 | 86% | 0 | 0% | 110 | 97% |
| Connecticut | 85 | 84 | 99% | 71 | 84% | 2 | 2% | 73 | 86% | 22 | 26% | 0 | 0% | 21 | 95% |
| Delaware | 46 | 46 | 100% | 43 | 93% | 2 | 4% | 45 | 98% | 41 | 89% | 0 | 0% | 39 | 95% |
| Florida | 383 | 338 | 88% | 308 | 80% | 5 | 1% | 313 | 82% | 141 | 37% | 2 | 1% | 130 | 92% |
| Georgia | 292 | 279 | 96% | 260 | 89% | 5 | 2% | 265 | 91% | 230 | 79% | 0 | 0% | 220 | 96% |
| Hawaii | 152 | 152 | 100% | 146 | 96% | 3 | 2% | 149 | 98% | 134 | 88% | 0 | 0% | 132 | 99% |
| Idaho | 20 | 20 | 100% | 20 | 100% | 0 | 0% | 20 | 100% | 13 | 65% | 0 | 0% | 13 | 100% |
| Illinois | 168 | 161 | 96% | 159 | 95% | 1 | 1% | 160 | 95% | 133 | 79% | 0 | 0% | 128 | 96% |
| Indiana | 130 | 130 | 100% | 124 | 95% | 0 | 0% | 124 | 95% | 109 | 84% | 0 | 0% | 109 | 100% |
| Iowa | 100 | 96 | 96% | 96 | 96% | 1 | 1% | 97 | 97% | 78 | 78% | 0 | 0% | 74 | 95% |
| Kansas | 52 | 52 | 100% | 48 | 92% | 0 | 0% | 48 | 92% | 33 | 63% | 0 | 0% | 33 | 100% |
| Kentucky | 78 | 60 | 77% | 38 | 49% | 8 | 10% | 46 | 59% | 46 | 59% | 0 | 0% | 46 | 100% |
| Louisiana | 149 | 136 | 91% | 128 | 86% | 5 | 3% | 133 | 89% | 81 | 54% | 0 | 0% | 78 | 96% |
| Maine | 11 | 9 | 82% | 7 | 64% | 0 | 0% | 7 | 64% | 6 | 55% | 2 | 33% | 4 | 67% |
| Maryland | 253 | 243 | 96% | 168 | 66% | 1 | 0% | 169 | 67% | 163 | 64% | 0 | 0% | 161 | 99% |
| Massachusetts | 305 | 304 | 100% | 287 | 94% | 1 | 0% | 288 | 94% | 255 | 84% | 0 | 0% | 251 | 98% |
| Michigan | 154 | 153 | 99% | 144 | 94% | 1 | 1% | 145 | 94% | 118 | 77% | 0 | 0% | 117 | 99% |
| Minnesota | 378 | 377 | 100% | 361 | 96% | 4 | 1% | 365 | 97% | 311 | 82% | 0 | 0% | 303 | 97% |
| Mississippi | 53 | 50 | 94% | 47 | 89% | 6 | 11% | 53 | 100% | 26 | 49% | 2 | 8% | 18 | 69% |
| Missouri | 93 | 87 | 94% | 80 | 86% | 0 | 0% | 80 | 86% | 56 | 60% | 0 | 0% | 51 | 91% |
| Montana | 3 | 3 | 100% | 3 | 100% | 0 | 0% | 3 | 100% | 3 | 100% | 0 | 0% | 3 | 100% |
| Nebraska | 60 | 56 | 93% | 55 | 92% | 0 | 0% | 55 | 92% | 49 | 82% | 0 | 0% | 47 | 96% |
| Nevada | 73 | 67 | 92% | 65 | 89% | 0 | 0% | 65 | 89% | 52 | 71% | 0 | 0% | 49 | 94% |
| New Hampshire | 13 | 13 | 100% | 11 | 85% | 0 | 0% | 11 | 85% | 11 | 85% | 0 | 0% | 11 | 100% |
| New Jersey | 297 | 278 | 94% | 263 | 89% | 7 | 2% | 270 | 91% | 147 | 49% | 0 | 0% | 124 | 84% |
| New Mexico | 11 | 11 | 100% | 11 | 100% | 0 | 0% | 11 | 100% | 7 | 64% | 0 | 0% | 7 | 100% |
| New York State | 246 | 239 | 97% | 232 | 94% | 1 | 0% | 233 | 95% | 202 | 82% | 0 | 0% | 196 | 97% |
| North Carolina | 202 | 199 | 99% | 187 | 93% | 3 | 1% | 190 | 94% | 143 | 71% | 2 | 1% | 134 | 94% |
| North Dakota | 40 | 40 | 100% | 35 | 88% | 0 | 0% | 35 | 88% | 24 | 60% | 0 | 0% | 24 | 100% |
| Ohio | 282 | 251 | 89% | 266 | 94% | 2 | 1% | 268 | 95% | 171 | 61% | 1 | 1% | 157 | 92% |
| Oklahoma | 66 | 64 | 97% | 59 | 89% | 1 | 2% | 60 | 91% | 47 | 71% | 1 | 2% | 43 | 91% |
| Oregon | 101 | 100 | 99% | 93 | 92% | 2 | 2% | 95 | 94% | 80 | 79% | 0 | 0% | 75 | 94% |
| Pennsylvania | 157 | 157 | 100% | 150 | 96% | 1 | 1% | 151 | 96% | 126 | 80% | 1 | 1% | 125 | 99% |
| Rhode Island | 40 | 40 | 100% | 24 | 60% | 12 | 30% | 36 | 90% | 36 | 90% | 0 | 0% | 36 | 100% |
| South Carolina | 74 | 65 | 88% | 69 | 93% | 3 | 4% | 72 | 97% | 58 | 78% | 0 | 0% | 58 | 100% |
| South Dakota | 25 | 25 | 100% | 25 | 100% | 0 | 0% | 25 | 100% | 18 | 72% | 0 | 0% | 17 | 94% |
| Tennessee | 143 | 141 | 99% | 131 | 92% | 3 | 2% | 134 | 94% | 105 | 73% | 1 | 1% | 100 | 95% |
| Texas | 647 | 624 | 96% | 550 | 85% | 5 | 1% | 555 | 86% | 438 | 68% | 1 | 0% | 428 | 98% |
| Utah | 71 | 69 | 97% | 70 | 99% | 0 | 0% | 70 | 99% | 59 | 83% | 0 | 0% | 58 | 98% |
| Vermont | 7 | 7 | 100% | 6 | 86% | 0 | 0% | 6 | 86% | 1 | 14% | 0 | 0% | 1 | 100% |
| Virginia | 282 | 268 | 95% | 254 | 90% | 0 | 0% | 254 | 90% | 165 | 59% | 1 | 1% | 159 | 96% |
| Washington | 303 | 291 | 96% | 271 | 89% | 2 | 1% | 273 | 90% | 234 | 77% | 0 | 0% | 204 | 87% |
| West Virginia | 21 | 20 | 95% | 21 | 100% | 0 | 0% | 21 | 100% | 17 | 81% | 0 | 0% | 17 | 100% |
| Wisconsin | 128 | 127 | 99% | 113 | 88% | 2 | 2% | 115 | 90% | 86 | 67% | 0 | 0% | 85 | 99% |
| Wyoming | 2 | 2 | 100% | 2 | 100% | 0 | 0% | 2 | 100% | 2 | 100% | 0 | 0% | 2 | 100% |
| City | |||||||||||||||
| Chicago | 96 | 96 | 100% | 95 | 99% | 0 | 0% | 95 | 99% | 80 | 83% | 0 | 0% | 76 | 95% |
| District of Columbia | 34 | 34 | 100% | 32 | 94% | 0 | 0% | 32 | 94% | 29 | 85% | 0 | 0% | 29 | 100% |
| Houston | 139 | 129 | 93% | 107 | 77% | 1 | 1% | 108 | 78% | 96 | 69% | 0 | 0% | 95 | 99% |
| New York City | 1,083 | 1,077 | 99% | 973 | 90% | 8 | 1% | 981 | 91% | 918 | 85% | 3 | 0% | 891 | 97% |
| Philadelphia | 139 | 135 | 97% | 124 | 89% | 6 | 4% | 130 | 94% | 108 | 78% | 0 | 0% | 106 | 98% |
| San Antonio | 34 | 34 | 100% | 31 | 91% | 0 | 0% | 31 | 91% | 26 | 76% | 0 | 0% | 25 | 96% |
| Territory | |||||||||||||||
| American Samoa | 7 | 7 | 100% | 6 | 86% | 0 | 0% | 6 | 86% | 0 | 0% | 0 | 0% | 0 | 0% |
| Guam | 12 | 12 | 100% | 3 | 25% | 5 | 42% | 8 | 67% | 0 | 0% | 0 | 0% | 0 | 0% |
| N. Mariana Islands | 9 | 9 | 100% | 8 | 89% | 1 | 11% | 9 | 100% | 7 | 78% | 0 | 0% | 7 | 100% |
| Puerto Rico | 3 | 3 | 100% | 1 | 33% | 0 | 0% | 1 | 33% | 0 | 0% | 0 | 0% | 0 | 0% |
| Virgin Islands | 3 | 3 | 100% | 1 | 33% | 1 | 33% | 2 | 67% | 0 | 0% | 0 | 0% | 0 | 0% |
| Freely Associated Island Nations | |||||||||||||||
| Micronesia | 35 | 35 | 100% | 23 | 66% | 3 | 9% | 26 | 74% | 0 | 0% | 0 | 0% | 0 | 0% |
| Republic of the Marshall Island | U | U | U | U | U | U | U | U | U | U | U | U | U | U | U |
| Palau | 17 | 17 | 100% | 17 | 100% | 0 | 0% | 17 | 100% | 0 | 0% | 0 | 0% | 0 | 0% |
* These data only include infants followed by the Perinatal Hepatitis B Prevention Program (PHBPP). National and jurisdictional level HepB vaccination coverage rates are available via annual MMWR publications of National Immunization Survey data (https://www.cdc.gov/vaccines/imz-managers/nis/index.html) and via VaxView (https://www.cdc.gov/vaccines/vaxview/index.html).
† Post vaccination serologic testing includes a test for HBsAg, anti-HBs, or both.
§ Anti-HBs >10 mIU/mL
¶ Percentage is among infants that completed the vaccine series and received PVST (postvaccination serological testing).
This table summarizes outcome data on infants born to persons with hepatitis B virus infection from the CDC Perinatal Hepatitis B Prevention Program. The 2018 birth cohort includes infants born in 2018 and followed through December 31, 2019. Among the 9,950 infants managed by the Perinatal Hepatitis B Prevention Program, 97% received recommended prophylaxis at birth, 88% completed the vaccine series, and 69% received recommended post-vaccination serologic testing. Among infants with post-vaccination testing (6,828), there were 23 (0.3%) cases of perinatal hepatitis B transmission; the proportion of infants testing positive for hepatitis B was lower among those who received prophylaxis within 1 day of birth (21/6,697, 0.3%) compared to those who did not (2/131, 1.5%).
Figure. Outcomes of infants born to hepatitis B infected persons and managed by the CDC Perinatal Hepatitis B Prevention Program, by birth cohort year —56 US Jurisdictions*, 2009–2018
PEP (postexposure prophylaxis), number of infants who received PEP (hepatitis B immune globulin and 1st dose of hepatitis B vaccine) for hepatitis B infection;
PVST (postvaccination serological testing), number of infants who received PVST after hepatitis B vaccine series completion.
* Includes 50 states, District of Columbia, and 5 cities. Excludes territories and freely associated island nations.
Number of infants managed in the Perinatal Hepatitis B Prevention Program from 50 states, District of Columbia, and 5 cities was 11,551 in 2009 and 9,864 in 2018. During 2009 to 2018, the percentage of infants managed who received PEP has remained relatively stable between 95% to 97% each year. The percentage of infants managed who received PSVT has increased from 59% (6,792 of 11,551 infants managed) in 2009 to 69% (6,820 of 9,864 infants managed) in 2018.