Numbers and rates* of reported cases† of acute Hepatitis C virus infection, by demographic characteristics — United States, 2017–2021

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◀ Table 3.1
Table 3.3 ▶
Numbers and rates* of reported cases† of acute Hepatitis C virus infection, by demographic characteristics — United States, 2017–2021
Table 2.2.
Characteristics 2017 No. 2017 Rate* 2018 No. 2018 Rate* 2019 No. 2019 Rate* 2020 No. 2020 Rate* 2021 No. 2021 Rate*
Total § 3,216 1.0 3,621 1.2 4,136 1.3 4,798 1.5 5,023 1.6
Age (Years)
0–19 103 0.1 81 0.1 63 0.1 57 0.1 67 0.1
20–29 1,189 2.7 1,310 3.0 1,262 2.9 1,230 2.8 1,045 2.5
30–39 937 2.3 1,070 2.6 1,347 3.2 1.526 3.5 1,551 3.5
40–49 441 1.1 494 1.3 664 1.7 820 2.1 901 2.3
50–59 332 0.8 366 0.9 442 1.1 578 1.4 696 1.7
≥60 185 0.3 295 0.4 358 0.5 586 0.8 753 1.0
Sex
Male 1,775 1.2 2,012 1.3 2,471 1.6 3,105 2.0 3,348 2.1
Female 1,431 0.9 1,605 1.0 1,653 1.0 1,687 1.0 1,669 1.0
Race/Ethnicity
American Indian/Alaska Native, non-Hispanic 67 2.9 83 3.6 83 3.6 48 2.1 55 2.7
Asian/Pacific Islander, non-Hispanic 23 0.1 29 0.1 36 0.2 76 0.4 67 0.3
Black, non-Hispanic 202 0.5 231 0.6 267 0.7 458 1.1 561 1.4
White, non-Hispanic 2,227 1.2 2,405 1.3 2,683 1.4 3,060 1.6 3,097 1.6
Hispanic 234 0.4 280 0.5 350 0.6 415 0.7 549 0.9
Urbanicity ¶
Urban 2,397 0.9 2,782 1.0 3,275 1.2 3,957 1.4 4,215 1.5
Rural 485 1.1 676 1.6 720 1.7 757 1.7 790 1.7
HHS Region: Regional Office **
Region 1: Boston 391 2.8 172 1.2 237 1.7 329 2.4 334 2.4
Region 2: New York 313 1.1 332 1.2 405 1.4 455 1.6 371 1.3
Region 3: Philadelphia 424 1.4 404 1.4 392 1.3 365 1.2 365 1.2
Region 4: Atlanta 826 1.3 1,056 1.7 1,253 2.0 1,957 2.9 2,247 3.3
Region 5: Chicago 692 1.3 977 1.9 1,053 2.0 902 1.7 835 1.6
Region 6: Dallas 105 0.2 114 0.3 157 0.4 384 0.9 405 0.9
Region 7: Kansas City 70 0.6 89 0.8 74 0.5 60 0.4 44 0.3
Region 8: Denver 162 1.4 225 1.9 222 1.9 138 1.1 184 1.5
Region 9: San Francisco 138 0.3 133 0.3 222 0.5 71 0.2 107 0.2
Region 10: Seattle 95 0.7 119 0.9 121 0.9 137 1.0 131 0.9

 

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Source: CDC, National Notifiable Diseases Surveillance System.

* Rates per 100,000 population. Beginning in 2021, single-race population estimates are used for rate calculations. For prior years, bridged-race population estimates are used. When comparing the 2021 rates by race/ethnicity to prior years, differences may be due to the change in denominator and should be interpreted with caution (see Technical Notes).
† Reported confirmed cases. For the case definition, see Acute Hepatitis C.
§ Numbers reported in each category may not add up to the total number of reported cases in a year due to cases with missing data or, in the case of race/ethnicity, cases categorized as “Other.”
Urbanicity was categorized according to the 2013 National Center for Health Statistics (NCHS) urban-rural classification scheme for counties and county-equivalent entities. Large central metro, large fringe metro, medium metro, and small metro counties were grouped as urban. Micropolitan and noncore counties were grouped as rural.
** US Department of Health and Human Services regions were categorized according to the grouping of states and US territories assigned under each of the 10 Department of Health and Human Services regional offices. For the purposes of this report, regions with US territories (Region 2 and Region 9) contain data from states only.

This table summarizes the epidemiology of acute hepatitis C in the United States. During 2021, rates of acute hepatitis C were highest among persons aged 20–49 years, males, non-Hispanic American Indian/Alaska Native persons, and those living in US Department of Health and Human Services Region 4 (Alabama, Florida, Georgia, Kentucky, Mississippi, North Carolina, South Carolina, and Tennessee).  

Using urbanicity categories defined by the National Center for Health Statistics, from 2020–2021 the rates of reported cases of acute hepatitis C increased in urban settings, but in 2021 rates remained slightly higher in rural settings compared with urban settings. Among all acute hepatitis C cases reported during 2021, 52% occurred among persons aged 20–39 years, 68% occurred among non-Hispanic White persons, and 84% occurred in urban areas.

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