Numbers and rates* of deaths with Hepatitis C listed as a cause of death† among residents, by state or jurisdiction — United States, 2017–2021
Source: CDC, National Center for Health Statistics (NCHS), Multiple Cause of Death on CDC WONDER Online Database. Data for 2017 are from the 1999–2020 bridged–race file and data for 2018–2021 are from the 2018–2021 single-race file. Data are based on information from all death certificates filed in the vital records offices of the 50 states and the District of Columbia through the Vital Statistics Cooperative Program. Deaths of nonresidents (e.g., nonresident aliens, nationals living abroad, residents of Puerto Rico, Guam, the Virgin Islands, and other US territories) and fetal deaths are excluded. Accessed at CDC Wonder on March 13, 2023. CDC WONDER data set documentation and technical methods can be accessed here and here.
* Rates are age-adjusted per 100,000 US standard population during 2000 by using the following age group distribution (in years): <1, 1–4, 5–14, 15–24, 25–34, 35–44, 45–54, 55–64, 65–74, 75–84, and ≥85. For age-adjusted death rates, the age-specific death rate is rounded to one decimal place before proceeding to the next step in the calculation of age-adjusted death rates for NCHS Multiple Cause of Death on CDC WONDER. This rounding step might affect the precision of rates calculated for small numbers of deaths. Missing data are not included.
† Cause of death is defined as one of the multiple causes of death and is based on the International Classification of Diseases, 10th Rev. (ICD-10) codes B17.1, and B18.2 (hepatitis C).
During 2021, a total of 13,895 hepatitis C-associated deaths were reported in the US Multiple Cause of Death data from the National Center for Health Statistics. Although death certificate data can help characterize deaths in the United States associated with hepatitis C, underreporting of hepatitis C as a primary or underlying cause of death does occur. Treatment of hepatitis C with direct-acting antiviral agents and sustained viral response is associated with reductions in mortality among persons with chronic hepatitis C.1 During 2021, the age-adjusted death rate was 3.18 deaths per 100,000 population, representing a 23% decrease from the corresponding rate during 2017. In 2021, the highest rates of death were observed in Oklahoma and the District of Columbia (11.05 and 9.20 deaths per 100,000 population, respectively), whereas the lowest rates were observed in Connecticut and Maine (1.18 and 1.25 deaths per 100,000 population, respectively).
- Figure 3.1. Number of reported cases of acute hepatitis C virus infection and estimated infections — United States, 2014–2021
- Figure 3.2. Rates of reported cases of acute hepatitis C virus infection, by state or jurisdiction — United States, 2020–2021
- Figure 3.3. Rates of reported cases of acute hepatitis C virus infection, by state or jurisdiction — United States, 2021
- Figure 3.4. Rates* of reported cases of acute hepatitis C virus infection, by age group — United States, 2006–2021
- Figure 3.5. Rates of reported cases of acute hepatitis C virus infection, by sex — United States, 2006–2021
- Figure 3.6. Rates of reported cases of acute hepatitis C virus infection, by race/ethnicity — United States, 2006–2021
- Figure 3.7. Availability of information on risk behaviors or exposures associated with reported cases of acute hepatitis C virus infection — United States, 2021
- Figure 3.8. Number of newly reported chronic hepatitis C virus infection cases by sex and age — United States, 2021
- Figure 3.9. Rates of death with hepatitis C virus infection listed as a cause of death among residents, by state or jurisdiction — United States, 2021
- Table 3.1. Numbers and rates of reported cases† of acute hepatitis C virus infection, by state or jurisdiction — United States, 2017–2021
- Table 3.2. Numbers and rates of reported cases† of acute hepatitis C virus infection, by demographic characteristics — United States, 2017–2021
- Table 3.3. Reported risk behaviors or exposures among reported cases of acute hepatitis C virus infection — United States, 2021
- Table 3.4. Number of newly reported cases of perinatal hepatitis C virus infection, by state or jurisdiction — United States, 2021
- Table 3.5. Number and rate of newly reported cases of chronic hepatitis C virus infection, by state or jurisdiction — United States, 2021
- Table 3.6. Number and rate of newly reported cases of chronic hepatitis C virus infection, by demographic characteristics — United States, 2021
- Table 3.7. Numbers and rates of deaths with hepatitis C listed as a cause of death among residents, by state or jurisdiction — United States, 2017–2021
- Table 3.8. Numbers and rates of deaths with hepatitis C virus infection listed as a cause of death among residents, by demographic characteristics — United States, 2017–2021
Source:
- Spradling PR, Zhong Y, Moorman AC, et al. The persistence of underreporting of hepatitis C as an underlying or contributing cause of death, 2011–2017. Clin Infect Dis. 2021 Sep 7;73(5):891–-894. doi: 10.1093/cid/ciab108. PMID: 33561187.