Numbers and rates* of deaths with Hepatitis B virus infections listed as a cause of death† among residents, by demographic characteristics — United States, 2017–2021

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◀ Table 2.7
Hepatitis C ▶
Numbers and rates* of deaths with Hepatitis B virus infections listed as a cause of death† among residents, by demographic characteristics — United States, 2017–2021
Rates of death with hepatitis B listed as a cause of death, by state or jurisdiction during 2021. States are grouped in quintiles based on the distribution of the reported rates of death per 100,000 population. Rates for states with fewer than 20 deaths are suppressed because of instability associated with those mortality rates.
Characteristics 2017 No. 2017 Rate*
(95% CI)		 2018 No. 2018 Rate*
(95% CI)		 2019 No. 2019 Rate*
(95% CI)		 2020 No. 2020 Rate*
(95% CI)		 2021 No. 2021 Rate*
(95% CI)
Total 1,727 0.46
(0.44–0.49)		 1,649 0.43
(0.41–0.45)		 1,662 0.42
(0.40–0.44)		 1,752 0.45
(0.42–0.47)		 1,748 0.44
(0.42–0.46)
Age (Years)
0–34 29 0.02
(0.01–0.03)		 32 0.02
(0.01–0.03)		 45 0.03
(0.02–0.04)		 36 0.02
(0.02–0.03)		 30 0.02
(0.01–0.03)
35–44 106 0.26
(0.21–0.31)		 122 0.30
(0.24–0.35)		 110 0.26
(0.21–0.31)		 109 0.26
(0.21–0.31)		 123 0.28
(0.23–0.33)
45–54 323 0.76
(0.68–0.85)		 283 0.68
(0.60–0.76)		 255 0.62
(0.55–0.70)		 269 0.67
(0.59–0.75)		 265 0.65
(0.57–0.73)
55–64 548 1.30
(1.20–1.41)		 520 1.23
(1.12–1.34)		 502 1.18
(1.08–1.29)		 483 1.14
(1.04–1.24)		 486 1.14
(1.03–1.24)
65–74 417 1.40
(1.27–1.54)		 422 1.38
(1.25–1.52)		 484 1.54
(1.40–1.67)		 495 1.52
(1.39–1.65)		 513 1.52
(1.39–1.66)
≥75 303 1.43
(1.27–1.59)		 270 1.23
(1.08–1.38)		 266 1.18
(1.04–1.32)		 360 1.56
(1.40–1.72)		 331 1.49
(1.33–1.65)
Sex
Male 1,275 0.70
(0.66–0.74)		 1,191 0.65
(0.61–0.69)		 1,248 0.66
(0.62–0.70)		 1,278 0.66
(0.63–0.70)		 1,260 0.65
(0.61–0.68)
Female 452 0.23
(0.20–0.25)		 458 0.22
(0.20–0.24)		 414 0.21
(0.19–0.24)		 474 0.22
(0.20–0.24)		 488 0.22
(0.20–0.24)
Race/Ethnicity
White, non-Hispanic 776 0.28
(0.26–0.30)		 754 0.27
(0.25–0.29)		 757 0.28
(0.26–0.30)		 739 0.27
(0.25–0.29)		 702 0.26
(0.24–0.28)
Black, non-Hispanic 320 0.74
(0.66–0.83)		 303 0.72
(0.63–0.80)		 290 0.67
(0.59–0.75)		 307 0.69
(0.61–0.77)		 306 0.66
(0.59–0.74)
Hispanic 109 0.26
(0.21–0.32)		 122 0.28
(0.23–0.33)		 117 0.27
(0.21–0.32)		 132 0.28
(0.23–0.33)		 136 0.28
(0.23–0.32)
Asian/Pacific Islander, non-Hispanic 492 2.45
(2.23–2.67)		 434 2.14
(1.94–2.35)		 457 2.13
(1.92–2.32)		 537 2.51
(2.30–2.73)		 564 2.54
(2.33–2.76)
Asian, non-Hispanic n/a n/a 417 2.13
(1.92–2.32)		 439 2.12
(1.92–2.32)		 514 2.48
(2.26–2.70)		 528 2.43
(2.22–2.64)
Native Hawaiian or Other Pacific Islander, non-Hispanic n/a n/a 17 UR 18 UR 23 3.89
(2.44–.89)		 36 5.95
(4.12–8.31)
American Indian/Alaska Native, non-Hispanic 17 UR S UR 16 UR 16 UR 16 UR
Multiple race, non-Hispanic n/a n/a 12 UR 15 UR 12 UR 14 UR
HHS Region: Regional Office ¶
Region 1: Boston 60 0.35
(0.27–0.46)		 64 0.34
(0.26–0.45)		 43 0.22
(0.16–0.30)		 49 0.24
(0.18–0.33)		 58 0.28
(0.21–0.37)
Region 2: New York 166 0.47
(0.39–0.54)		 156 0.44
(0.36–0.51)		 147 0.42
(0.35–0.49)		 154 0.43
(0.36–0.50)		 149 0.41
(0.34–0.48)
Region 3: Philadelphia 128 0.32
(0.27–0.38)		 130 0.35
(0.29–0.41)		 126 0.32
(0.26–0.38)		 135 0.35
(0.29–0.41)		 130 0.34
(0.28–0.40)
Region 4: Atlanta 365 0.45
(0.41–0.50)		 346 0.45
(0.40–0.50)		 348 0.42
(0.38–0.47)		 352 0.43
(0.39–0.48)		 338 0.42
(0.37–0.47)
Region 5: Chicago 184 0.29
(0.24–0.33)		 174 0.28
(0.24–0.33)		 173 0.27
(0.23–0.31)		 212 0.33
(0.29–0.38)		 217 0.33
(0.28–0.37)
Region 6: Dallas 247 0.55
(0.48–0.62)		 230 0.47
(0.41–0.53)		 230 0.48
(0.42–0.55)		 229 0.47
(0.40–0.53)		 261 0.53
(0.46–0.59)
Region 7: Kansas City 50 0.29
(0.22–0.39)		 65 0.38
(0.29–0.48)		 51 0.30
(0.22–0.40)		 51 0.32
(0.23–0.42)		 35 0.21
(0.15–0.30)
Region 8: Denver 48 0.37
(0.27–0.49)		 34 0.25
(0.17–0.35)		 47 0.32
(0.23–0.43)		 54 0.41
(0.31–0.54)		 48 0.34
(0.25–0.45)
Region 9: San Francisco 393 0.69
(0.62–0.76)		 369 0.62
(0.56–0.69)		 394 0.64
(0.57–0.70)		 411 0.66
(0.59–0.72)		 408 0.68
(0.61–0.74)
Region 10: Seattle 86 0.52
(0.41–0.64)		 81 0.47
(0.37–0.59)		 103 0.58
(0.47–0.70)		 105 0.60
(0.48–0.72)		 104 0.61
(0.49–0.73)

 

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Source: CDC, National Center for Health Statistics (NCHS), Multiple Cause of Death on CDC WONDER Online Database. Data for 2017 are from the 1999–2020 bridged-race file and data for 2018–2021 are from the 2018–2021 single-race file. Rates for 2018–2020 may differ from previously published rates due to the change from bridged-race to single-race categories. Data are reported for non-Hispanic Asian/Pacific Islander persons and also separately for non-Hispanic Asian persons and non-Hispanic Native Hawaiian persons (shown in italics). Data are based on information from all death certificates filed in the vital records offices of the 50 states and the District of Columbia through the Vital Statistics Cooperative Program. Deaths of nonresidents (e.g., nonresident aliens, nationals living abroad, residents of Puerto Rico, Guam, the Virgin Islands, and other US territories) and fetal deaths are excluded.  Accessed at CDC Wonder on March 13, 2023. CDC WONDER dataset documentation and technical methods can be accessed here.
* Rates for race/ethnicity, sex, US Department of Health and Human Services region, and the overall total are age-adjusted per 100,000 US standard population during 2000 by using the following age group distribution (in years): <1, 1–4, 5–14, 15–24, 25–34, 35–44, 45–54, 55–64, 65–74, 75–84, and ≥85. For age-adjusted death rates, the age-specific death rate is rounded to one decimal place before proceeding to the next step in the calculation of age-adjusted death rates for NCHS Multiple Cause of Death on CDC WONDER. This rounding step might affect the precision of rates calculated for small numbers of deaths. Missing data are not included.
† Cause of death is defined as one of the multiple causes of death and is based on the International Classification of Diseases, 10th Revision (ICD-10) codes B16, B17.0, B18.0, B18.1 (hepatitis B).
§ The bridged-race categories were used for 2017 while single-race categories were used during 2018–2021. Single-race and bridged-race categories are not directly comparable (see Technical Notes).
¶ US Department of Health and Human Services regions were categorized according to the grouping of states and US territories assigned under each of the 10 Health and Human Services regional offices. For the purposes of this report, regions with US territories (Regions 2 and 9) contain data from states only.
n/a: Not applicable. This race category was not available for 2017 data.
UR: Unreliable rate. Rates where death counts were less than 20 were not displayed because of the instability associated with those rates.
S: Suppressed. In order to prevent revealing information that may identify specific individuals, small data values are not available when the count falls below a ratio of the representative demographic population.

This table summarizes the characteristics of hepatitis B-associated deaths among residents in the United States. During 2021, a total of 1,748 hepatitis B-associated deaths among US residents were reported in the US Multiple Cause of Death data from the National Center for Health Statistics, which corresponds to an age-adjusted death rate of 0.44 cases per 100,000 population.

The US age-adjusted death rates for hepatitis B have been relatively consistent during the five-year period from 2017–2021. In 2021, the mortality rate was highest among non-Hispanic Asian/Pacific Islander persons (2.54 deaths per 100,000 population), almost 10 times the rate among non-Hispanic White persons (0.26 deaths per 100,000 population). Due to changes in the type of race and ethnicity data available from the National Vital Statistics System (NVSS) (see Technical Notes), for the first time, data for hepatitis B-associated deaths is reported separately for non-Hispanic Asian persons with a rate of 2.43 deaths per 100,000 population, and for non-Hispanic Native Hawaiian or Other Pacific Islander persons with a rate of 5.95 deaths per 100,000 persons almost 23 times the rate among non-Hispanic White persons. Variations of disease rates by race or ethnicity may reflect systemic cultural, behavioral, environmental, and social factors, including structural racism.

Hepatitis B-associated mortality rates were also higher among persons aged 55 years and older, males, and in US Department of Health and Human Services Regions 9 (Arizona, California, Hawaii, and Nevada) and 10 (Alaska, Idaho, Oregon, and Washington).

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