Number of reported acute and chronic cases* of Hepatitis C virus infection by case status — United States, 2021

Number of reported acute and chronic cases* of Hepatitis C virus infection by case status — United States, 2021
For 2021, cases that meet both the confirmed and probable case definitions for acute hepatitis C and newly reported chronic hepatitis C are summarized to show the total burden of cases reported by jurisdictions to CDC.
Acute Hepatitis C Chronic Hepatitis C
State or Jurisdiction Confirmed Probable Confirmed Probable
Alabama 110 19 4,273 3,346
Alaska N N 498 301
Arizona U U U U
Arkansas 44 17 2,189 1,560
California† 100 5 9,717 14,381
Colorado 3 2 1,737 949
Connecticut 36 809
Delaware 58 1 710 291
District of Columbia U U U U
Florida 1,545 264 9,130 3,776
Georgia 114 65 4,405 6,392
Hawaii U U
Idaho 669 827
Illinois 230 12 2,759 1,285
Indiana 179 18 N N
Iowa 21 729 4
Kansas 2 26 647 1,270
Kentucky 198 113 N N
Louisiana 308 1 3,634 1,188
Maine 134 34 704 870
Maryland 51 3 2,142 1,756
Massachusetts 161 11 2,346 1,461
Michigan 103 22 2,396 1,696
Minnesota 64 2 843 160
Mississippi 3 47 1,951
Missouri 11 4,267
Montana 26 3 684 356
Nebraska 10 414 261
Nevada 7 1,904 2,503
New Hampshire 3 14 47 82
New Jersey 88 6 2,366 2,604
New Mexico 288 121
New York 283 15 4,695 2,295
North Carolina 67 31 N N
North Dakota 461 189
Ohio 126 27 6,661 5,471
Oklahoma 30 18 2,196 5,452
Oregon 21 7 1,657 2,097
Pennsylvania 158 6,891 4,090
Rhode Island U U U U
South Carolina 2 3 3,448 4,293
South Dakota 4 425 417
Tennessee 208 91 6,945 4,285
Texas 23 14 N N
Utah 149 73 835 863
Vermont 307 68
Virginia 27 12 3,792 2,840
Washington 110 12 2,566 1,425
West Virginia 71 13 2,699 2,110
Wisconsin 133 4 1,385 522
Wyoming 2 319
Total 5,023 1,005 107,540 83,857

Source: CDC, National Notifiable Diseases Surveillance System.
* Confirmed and probable case definition available for Acute Hepatitis C and for Chronic Hepatitis C.
† California excludes chronic hepatitis C case counts from Los Angeles County (except for the City of Long Beach and the City of Pasadena) and San Diego County, geographic areas which include approximately 32% of California’s total population.
—: No reported cases. The reporting jurisdiction did not submit any cases to CDC.
N: Not reportable. The disease or condition was not reportable by law, statue, or regulation in the reporting jurisdiction.
U: Unavailable. The data were unavailable.

For 2021, cases that meet both the confirmed and probable case definitions for acute hepatitis C and newly reported chronic hepatitis C are summarized to show the total burden of cases reported by jurisdictions to CDC.

The ability of a jurisdiction to apply the case definitions varies (see Technical Notes). Cases of probable hepatitis C require a positive test for antibodies to hepatitis C virus (anti-HCV) and an absence of other case definition criteria.

Therefore, it is unknown if cases represent current hepatitis C virus infection or a resolved hepatitis C virus infection. Jurisdictions without a public health reporting law or mandate for negative ribonucleic acid (RNA) test results will classify a positive anti-HCV test result as a probable case of hepatitis C.

Whereas jurisdictions with a public health reporting law or mandate for negative RNA test results will be more able to determine whether a positive anti-HCV test result is not a case (i.e., evidence of prior infection). For this reason, caution should be taken when comparing case counts for probable acute and chronic hepatitis C across jurisdictions.