To determine probability of causation for a cancer case under the Act, the Department of Labor (DOL) uses a computer software application NIOSH has developed in collaboration with the National Cancer Institute, called NIOSH-IREP (Interactive RadioEpidemiological Program)external icon.
NIOSH-IREP was adapted from the National Institutes of Health’s (NIH) Interactive RadioEpidemiological Program (NIH-IREP) developed by the National Cancer Institute (NCI) to update the 1985 NIH Radioepidemiological Tables.
NIOSH-IREP is a science-based tool that allows DOL to determine the probability a cancer was caused by a person’s radiation dose from nuclear weapons production work. The actual outcome of a case depends on a number of important factors such as the dose estimates of past exposures and the type of cancer that has been diagnosed. NIOSH is responsible for maintaining and updating this software and the scientific elements (cancer risk models) that it uses.
Access and Use
The NIOSH-IREP interactive software program can be found at: https://www.niosh-irep.com/irep_nioshexternal icon. Data can be entered manually or by using a NIOSH-provided input file. Users also have the ability to calculate PC from multiple primary cancers.
User’s Guide Version 5.9 pdf icon[902 KB (22 pages)]
Recently, an issue with the Acute Lymphocytic Leukemia cancer model was found, and it is now corrected in the IREP version v.5.9. Here is a complete description with all the changes that were made in NIOSH-IREP v.5.9:
Fixed issue related to Acute Lymphocytic Leukemia claims
A small issue was identified and fixed related to Acute Lymphocytic Leukemia claims involving exposures to neutrons or alpha particles. Claims evaluated using v.5.9 will result in slight changes in PC values, with a tendency towards larger PC values for claims involving exposures to neutrons and towards lower PC values for claims involving exposures to alpha particles.
Improved Validation Checks
This version includes additional validation checks on user input to provide friendly warnings or messages when invalid inputs are entered.
Example Input Files
Below are example input files that may be uploaded into NIOSH-IREP. The User’s Guide provides instructions for uploading input files. Summaries of the example files are also provided. To work properly, the files must first be saved to a disk or to your computer. From there, they can be uploaded directly into the program.
Subject Matter Expert Review
Comments from Roy E. Shore, Ph.D., Dr. P.H., Professor, Department of Environmental Medicine, Director, Division of Epidemiology and Biostatistics, New York University, School of Medicine. pdf icon[164 KB (4 pages)]
Comments from Daniel O. Stram, Ph.D., Associate Professor, Keck School of Medicine, Department of Preventive Medicine, Division of Biostatistics, University of Southern California. pdf icon[439 KB (5 pages)]
Information on previous updates to the NIOSH-IREP program can be found at https://www.niosh-irep.com/irep_niosh/update.aspexternal icon.
The public may comment on NIOSH-IREP at any time. Comments can be sent by e-mail to email@example.com.
Comments can be mailed to:
National Institute for Occupational Safety and Health
Division of Compensation Analysis and Support
1090 Tusculum Avenue, Mailstop C-45
Cincinnati, Ohio 45226