Reduce estimated new hepatitis C virus infections by 20% or more

Reduce estimated new hepatitis C virus infections by 20% or more
National Progress Report 2025 Goal
X on red, indicating "Not met, no change or moved away from annual target"

Status: Annual target was not met and has not changed or moved away  from annual target

Check-mark on green, indicating "Met or exceeded current annual target"

Met or exceeded current annual target

Arrow on yellow, indicating "not met, moved toward annual target"

Moving toward annual target, but annual target was not fully met

X on red, indicating "Not met, no change or moved away from annual target"

Annual target was not met and has not changed or moved away  from annual target

Source: CDC, National Notifiable Diseases Surveillance System.1
* The number of estimated viral hepatitis infections was determined by multiplying the number of reported cases by a factor that adjusted for underascertainment and underreporting.1,2

Summary of Findings

New hepatitis C virus (HCV) infections have increased each year since 2013 with 69,800 estimated infections in 2021, well above the 2021 target of 38,233 estimated infections. Recent increases are thought to reflect both true increases in incidence and improved case ascertainment resulting from a change in the hepatitis C surveillance case definition in 2020. Injection drug use is the most common risk reported for persons with new HCV infection, and increases in hepatitis C incidence are temporally associated with increases in this risk behavior. A small proportion of cases can be attributed to healthcare-associated outbreaks of hepatitis C. During 2020 and 2021, there were major disruptions in access to medical care, testing, and routine viral hepatitis public health activities due to the COVID-19 pandemic; therefore, 2020 and 2021 data should be interpreted with caution.

Reduction needed to meet 2025 goal:

A 50% reduction from the estimated number of new HCV infections in 2021 is needed to meet the 2025 goal of 35,000 estimated infections.

This reduction can best be achieved by:

  • Supporting routine hepatitis C screening for all adults, at least once in their life and for every pregnant person during each pregnancy.
  • Expanding regular testing and hepatitis C-related services for persons with certain risk factors for HCV infection and persons with hepatitis C to increase their access to curative care and treatment.
  • Continuing to support medical education and developing partnerships with service providers to reach people with hepatitis C.
  • Building capacity within jurisdictions to make it easier for them to collect and use a core set of surveillance data as well as prioritize new data collection initiatives (molecular, computational, informational) that will help pinpoint where HCV infection is occurring, understand transmission networks, enhance what we learn from outbreak investigations, and thereby prioritize prevention efforts.
  • Increasing access to substance use disorder treatment and care services including medication-assisted treatment programs by implementing comprehensive community-level programs especially for disproportionately affected populations.
  • Conducting research focused on improving prevention strategies and increasing awareness of hepatitis C.
  • Building and harnessing partnerships that amplify the use of effective prevention strategies in persons and places with higher rates of HCV transmission.

Technical Notes

Data Sources:
CDC, National Notifiable Diseases Surveillance System (NNDSS)

Number of estimated acute HCV infections

Not applicable

Indicator Notes:
NNDSS is a nationwide collaboration that enables all levels of public health to share notifiable disease-related health information.1 Surveillance for viral hepatitis through NNDSS is based on case definitions developed and approved by the Council of State and Territorial Epidemiologists (CSTE) and CDC. Reported cases of acute hepatitis C are required to meet specific clinical and laboratory criteria. Estimated infections are based on laboratory-confirmed cases of acute viral hepatitis; these estimates are presented in the 2021 Annual Surveillance Report1 along with their 95% Confidence Intervals to show the range of estimated infections accounting for error. Acute hepatitis C is reportable in all jurisdictions except Alaska. Healthcare providers, hospitals, and/or laboratories report cases to the local or state health department, and states voluntarily submit reports or notify CDC of newly diagnosed cases of hepatitis C that meet the CSTE/CDC surveillance case definition. To account for underascertainment and underreporting, the number of reported cases is multiplied by 13.9. The methods for developing the multiplication factor are documented in Klevens et al. and used by CDC to estimate the number of annual infections.1,2

Goal Setting:
The 2025 goal of 35,000 estimated cases is consistent with CDC’s Division of Viral Hepatitis 2025 Strategic Plan and the US Department of Health and Human Services’ 2021–2025 Viral Hepatitis National Strategic Plan. Annual targets assume a constant (linear) rate of change from the observed baseline (2017 data year) to the 2025 goal (2023 data year).

The number of estimated infections is based on a simple, probabilistic model for estimating the proportion of patients who were symptomatic, received testing, and were reported to health officials in each year.2 This constant multiplier may not account for variations over time in underreporting and underascertainment due to changes in public and provider awareness, laboratory and diagnostic techniques, and the definition of the condition.

  1. Centers for Disease Control and Prevention. Viral Hepatitis Surveillance – United States, 2021. Published August 2023. Accessed [date].
  2. Klevens RM, Liu S, Roberts H, Jiles RB, Holmberg SD. Estimating acute viral hepatitis infections from nationally reported cases. Am J Public Health 2014;104(3):482–7.