National Progress Report 2025: Reduce reported rate* of new hepatitis C virus infections among persons who inject drugs† by ≥25%

Incidence rate* of reported acute hepatitis C cases among persons aged 18-40 years

Bar chart for years 2013-2023, charting rate, starting at 1.6in 2013, rising to 2.6 by 2018, and then projected downward to 1.7 by 2023.

Source: CDC, National Notifiable Diseases Surveillance System (1)
*Rate per 100,000 U.S. population.
†Persons aged 18–40 years serve as a proxy for persons who inject drugs.

Summary of Findings

The rate of acute hepatitis C cases reported to CDC among person aged 18–40 years has increased steadily each year since 2013 to 2.6 cases per 100,000 U.S. population in 2018, above the 2018 target rate of 2.2 per 100,000. Injection-drug use is the most common risk reported for persons with new hepatitis C virus infection, and increases in hepatitis C incidence, particularly among persons aged 18–40 years are temporally associated with increases in this risk factor (1).

Reduction needed to meet 2025 goal: A 34.6% reduction from the 2018 rate of reported acute hepatitis C cases is needed to meet the 2025 goal of 1.7 cases per 100,000 population.

This reduction can best be achieved by

  • Supporting local, state, and federal public health surveillance and other data-collection initiatives to detect where HCV transmission is occurring and providing evidence to guide strategies aimed at reducing hepatitis C incidence among the most at-risk groups, particularly persons who inject drugs (PWID).
  • Providing hepatitis C-related health services, including routine hepatitis C testing for PWID and appropriate care and curative hepatitis C treatment for PWID living with hepatitis C.
  • Implementing audience-friendly and culturally and linguistically responsive educational campaigns to encourage testing among PWID.
  • Supporting implementation of comprehensive community-level programs for PWID (e.g., access to syringe services programs, linkage to medication-assisted treatment programs, testing, and treatment).
  • Conducting prevention research to improve the effectiveness of hepatitis C prevention and decrease hepatitis C incidence among PWID.
  • Building partnerships to promote implementation of prevention strategies in settings that serve PWID to increase availability and utilization of hepatitis C prevention services in these settings.

Technical Notes

Data Sources: CDC, National Notifiable Diseases Surveillance System (NNDSS) and CDC/NCHS/U.S. Census Bureau, Bridged-race Population Estimates

Numerator: Number of acute HCV infections reported annually among persons aged 18–40 years

Denominator: Total population of persons aged 18–40 years in reporting jurisdictions

Indicator Notes: (1) The NNDSS is a nationwide collaboration that enables all levels of public health to share notifiable-disease-related health information. Surveillance for viral hepatitis through NNDSS is based on case definitions developed and approved by the Council of State and Territorial Epidemiologists (CSTE) and CDC. Reported cases of acute viral hepatitis C are required to meet specific clinical and laboratory criteria. Only laboratory-confirmed cases of acute viral hepatitis are presented in this report. Acute hepatitis C is reportable in all jurisdictions. Health-care providers, hospitals, and/or laboratories report cases to the local or state health department, and states voluntarily submit reports or notify CDC of newly diagnosed cases of hepatitis C that meet the surveillance case definition. Case rates per 100,000 U.S. population are calculated based on the projected resident population of the United States as of July 1 during each data-collection year.

Goal Setting: The 2025 goal of 1.7 per 100,000 U.S. population is consistent with CDC’s Division of Viral Hepatitis 2025 Strategic Plan. Annual targets assume a constant (linear) rate of change from the observed baseline (2017 data year) to the 2025 goal (2023 data year).

Limitations: Viral hepatitis is largely underreported in the NNDDS. Based on a simple, probabilistic model for estimating the proportion of patients who were symptomatic, received testing, and were reported to health officials in each year, the actual number of acute hepatitis C cases is estimated to be 13.9 times the number reported to CDC. (1–2) Additionally, rates may vary over time based on changes in public and provider awareness, changes in laboratory and diagnostic techniques, and changes in the definition of the condition.


  1. Centers for Disease Control and Prevention. Viral Hepatitis Surveillance—United States, 2018. Atlanta: US Department of Health and Human Services, Centers for Disease Control and Prevention; 2020. Available at:
  2. Klevens RM, Liu S, Roberts H, Jiles RB, Holmberg SD. Estimating acute viral hepatitis infections from nationally reported cases. Am J Public Health. 2014;104(3):482-7.