Use of COVID-19 Vaccines in the United States

Interim Clinical Considerations

Some 2023-2024 COVID-19 vaccines will expire in summer 2024. Expiration dates vary by manufacturer and vaccine. Always check the expiration date or beyond-use date/time to ensure it has not passed. Never use expired vaccine or diluent.

See the Interim Clinical Considerations for Use of COVID-19 Vaccines in the United States for information on interchangeability of COVID-19 vaccines.

Summary of recent changes (last updated April 4, 2024):
  • New guidance on COVID-19 vaccination and pemivibart (Pemgarda™), a monoclonal antibody authorized for COVID-19 pre-exposure prophylaxis in people who are moderately or severely immunocompromised and meet the FDA-authorized conditions for use.