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Dose–Response Association Between High-Density Lipoprotein Cholesterol and Stroke: A Systematic Review and Meta-Analysis of Prospective Cohort Studies


The 4 figures show a linear inverse dose–response association between high-density lipoprotein cholesterol level and risk of total stroke and subarachnoid hemorrhage, a nonlinear inverse dose–response association for ischemic stroke risk, but a linear positive dose–response association for intracerebral hemorrhage risk.

Linear dose–response association between high-density lipoprotein cholesterol and risk of stroke and stroke subtypes modeled with restricted cubic splines. Graph A shows total stroke; B, ischemic stroke; C, intracerebral hemorrhage; and D, subarachnoid hemorrhage.

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Page last reviewed: May 13, 2021