Current Knowledge on Correlations Between Highly Prevalent Dental Conditions and Chronic Diseases: An Umbrella Review
SYSTEMATIC REVIEW — Volume 16 — September 26, 2019
We identified 1,249 articles through a search of databases (Embase, n = 578; PubMed, n = 568; Cochrane, n = 76; LILACS, n = 27) and no articles through other sources. After removing duplicates, 992 articles remained and were screened. After screening titles and abstracts, 725 articles were excluded; 267 full-text articles were assessed for eligibility. Of these, 235 were excluded for the following reasons: not a systematic review (n = 96); did not report on one of the prioritized diseases (n = 50); reported on the same topic and period as an included umbrella review (n = 38); reported the same study as the included article (ie, duplicate) (n = 16); did not report on the link between prioritized diseases (n = 15); no full text or author contact details not listed (n = 10); not in English (n = 9); or did not report data separately for subjects older than 18 years (n = 1).
Flow diagram showing exclusion and inclusion process during the literature review based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) system. Articles were screened for an umbrella review of systematic reviews published between 1995 and 2017 on correlation between prevalent dental conditions and chronic diseases in Germany.
The figure illustrates the number of identified systematic reviews that investigated correlations between highly prevalent dental conditions and chronic diseases. Lines of varying width represent connections between the three dental diseases in the upper boxes (periodontitis, tooth loss and caries) and the chronic diseases in the 7 lower boxes (diabetes mellitus, cardiovascular disease, cerebrovascular disease, COPD, dementia, psoriasis, and lung cancer).
Illustration of the number of identified systematic reviews that showed disease correlations, umbrella review of systematic reviews published between 1995 and 2017 on correlation between prevalent dental conditions and chronic diseases in Germany. Width of lines illustrates the number of systematic reviews that report on the disease combinations. Abbreviation: COPD, chronic obstructive pulmonary disease.
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