A Randomized Controlled Trial Translating the Diabetes Prevention Program to a University Worksite, Ohio, 2012–2014
CME ACTIVITY — Volume 12 — November 25, 2015
Kellie R. Weinhold, MS, RD; Carla K. Miller, PhD, RD; David G. Marrero, PhD; Haikady N. Nagaraja, PhD; Brian C. Focht, PhD; Gregg M. Gascon, PhD
Suggested citation for this article: Weinhold KR, Miller CK, Marrero DG, Nagaraja HN, Focht BC, Gascon GM. A Randomized Controlled Trial Translating the Diabetes Prevention Program to a University Worksite, Ohio, 2012–2014. Prev Chronic Dis 2015;12:150301. DOI: http://dx.doi.org/10.5888/pcd12.150301.
Medscape, LLC is pleased to provide online continuing medical education (CME) for this journal article, allowing clinicians the opportunity to earn CME credit.
This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education through the joint providership of Medscape, LLC and Preventing Chronic Disease. Medscape, LLC is accredited by the ACCME to provide continuing medical education for physicians.
Medscape, LLC designates this Journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
All other clinicians completing this activity will be issued a certificate of participation. To participate in this journal CME activity: (1) review the learning objectives and author disclosures; (2) study the education content; (3) take the post-test with a 75% minimum passing score and complete the evaluation at www.medscape.org/journal/pcd; (4) view/print certificate.
Release date: November 25, 2015; Expiration date: November 25, 2016
Upon completion of this activity, participants will be able to:
- Describe the worksite lifestyle intervention used in this randomized trial among employees with prediabetes
- Discuss the efficacy of a worksite lifestyle intervention for improving metabolic risk factors among employees with prediabetes, based on a randomized trial
- Discuss the efficacy of a worksite lifestyle intervention for improving behavioral risk factors among employees with prediabetes
Editor, Preventing Chronic Disease
Disclosure: Ellen Taratus has disclosed no relevant financial relationships.
Laurie Barclay, MD
Freelance writer and reviewer, Medscape, LLC
Disclosure: Laurie Barclay, MD, has disclosed no relevant financial relationships.
Kellie R. Weinhold, MS, RD, The Ohio State University, Columbus, Ohio
Disclosure: Kellie R. Weinhold, MS, RD, has disclosed no relevant financil relationships.
Carla K. Miller, PhD, RD, The Ohio State University, Columbus, Ohio
Disclosure: Carla K. Miller, PhD, RD, has disclosed no relevant financial relationships.
David G. Marrero, PhD, Indiana University School of Medicine, Indianapolis, Indiana
Disclosure: David G. Marrero, PhD, has disclosed no relevant financial relationships.
Haikady N. Nagaraja, PhD, The Ohio State University, Columbus, Ohio
Disclosure: Haikady N. Nagaraja, PhD, has disclosed the following relevant financial relationships: Served as an advisor or consultant for: Abbott Nutrition.
Brian C. Focht, PhD, The Ohio State University, Columbus, Ohio
Disclosure: Brian C. Focht, PhD, has disclosed no relevant financial relationships.
Gregg M. Gascon, PhD, The Ohio State University Health Plan, Inc., Columbus, Ohio
Disclosure: Gregg M. Gascon, PhD, has disclosed no relevant financial relationships.
Working adults spend much time at the workplace, an ideal setting for wellness programs targeting weight loss and disease prevention. Few randomized trials have evaluated the efficacy of worksite diabetes prevention programs. This study evaluated the efficacy of a worksite lifestyle intervention on metabolic and behavioral risk factors compared with usual care.
A pretest–posttest control group design with 3-month follow-up was used. Participants with prediabetes were recruited from a university worksite and randomized to receive a 16-week lifestyle intervention (n = 35) or usual care (n = 34). Participants were evaluated at baseline, postintervention, and 3-month follow-up. Dietary intake was measured by a food frequency questionnaire and level of physical activity by accelerometers. Repeated measures analysis of variance compared the change in outcomes between and within groups.
Mean (standard error [SE]) weight loss was greater in the intervention (−5.5% [0.6%]) than in the control (−0.4% [0.5%]) group (P < .001) postintervention and was sustained at 3-month follow-up (P < .001). Mean (SE) reductions in fasting glucose were greater in the intervention (−8.6 [1.6] mg/dL) than in the control (−3.7 [1.6] mg/dL) group (P = .02) postintervention; both groups had significant glucose reductions at 3-month follow-up (P < .001). In the intervention group, the intake of total energy and the percentage of energy from all fats, saturated fats, and trans fats decreased, and the intake of dietary fiber increased (all P < .01) postintervention.
The worksite intervention improved metabolic and behavioral risk factors among employees with prediabetes. The long-term impact on diabetes prevention and program sustainability warrant further investigation.
The prevalence of prediabetes among US adults increased significantly from 30.2% in 1999–2002 to 36.5% in 2007–2010 (1). People with prediabetes are at increased risk for type 2 diabetes mellitus (hereinafter referred to as type 2 diabetes) as well as microvascular and macrovascular comorbidities commonly associated with type 2 diabetes (2). Rising rates of prediabetes create an urgent need to prevent or delay the development of type 2 diabetes.
Intensive lifestyle interventions can prevent or delay type 2 diabetes in at-risk populations (3–5). These interventions target weight loss by improving dietary patterns and increasing physical activity (PA). The Diabetes Prevention Program (DPP), for example, demonstrated that weight loss through lifestyle modification was more effective than pharmacotherapy in reducing the incidence of type 2 diabetes among adults with prediabetes, and the relative reduction in incidence remained at 10-year follow-up (3,6). The current need is to translate effective interventions into practice settings.
Adults spend a large portion of their time at work, making the workplace a potentially effective setting for health promotion and disease prevention. Wellness programs can generate savings in medical costs and reduce absenteeism rates. Although worksite programs can promote weight loss (7), limited evidence exists on worksite diabetes prevention programs for employees at high risk of diabetes. The workplace could be an opportune setting for identifying employees with prediabetes, reducing risk through effective programs, and if employees avert type 2 diabetes, also reducing future costs (8).
The DPP has been adapted for community settings such as churches, hospitals, and YMCAs (9). Although the community-based programs promoted weight loss, thereby reducing risk for type 2 diabetes (3,6), few translational studies have evaluated the efficacy of worksite diabetes prevention programs (10–13). Among worksite studies that implemented the DPP, only 2 studies used a randomized design with a comparison condition (10,13), 2 studies reported the impact of the intervention on outcomes such as glucose and lipid levels (10,12), and none reported changes in dietary intake or objectively measured PA. Moreover, one worksite study implemented a primarily self-directed, low-intensity version of the DPP (13), limiting comparability; in addition, study attrition was high (11,13). The objective of our trial was to evaluate the efficacy of a worksite lifestyle intervention among employees with prediabetes. It was hypothesized that the intervention would facilitate greater reductions in the percentage of weight loss than would usual care.
A randomized pretest–posttest control group design was used at a major university in the midwestern United States. Approval for the study was obtained from the university’s institutional review board, and all participants provided written, informed consent. Eligible participants were randomized at baseline to either a 16-week group-based lifestyle intervention or usual care from their health care providers (control condition) (Figure). Beginning in October 2012, participants were enrolled and allocated to treatment group in a 1-to-1 ratio by the project coordinator. Participants were randomized in blocks of 4 stratified by race and sex; 2 participants each were randomly assigned to the intervention or control arm. Assignment was generated by the statistician, and allocations were concealed in sequentially numbered opaque envelopes. The statistician was blinded to treatment assignment; however, neither participants nor lifestyle coaches were blinded to treatment allocation. All study appointments took place on the university campus. Postintervention data were collected after the 16-week intervention, followed by a 3-month maintenance period, during which participants received no contact from program staff; final data were collected 7 months after enrollment. Follow-up of participants was completed in May 2014 at trial end.
Figure. Phases of the randomized controlled trial for the intervention and usual care (control) groups in a university worksite diabetes prevention stud.y, Ohio, 2012–2014. [A text description of this figure is also available.]
Potentially eligible participants with random glucose levels of 110 to 199 mg/dL during an annual employee health screening received a letter from the university health plan inviting them to participate. Additional study recruitment methods included campus flyers, electronic advertisements in digital newsletters, employee email notifications, and notices in ResearchMatch.com, a website for study recruitment.
Eligibility criteria included being an employee aged 18 to 65 and having a body mass index (BMI) of 25.0 to 50.0 kg/m2 and prediabetes. The 7-item American Diabetes Association risk assessment questionnaire was administered to determine risk for type 2 diabetes, and those with a score of 5 or more were classified as potentially eligible and screened for any exclusionary criteria (14). Eligible participants had fasting finger-stick glucose levels of 100 to 125 mg/dL, indicative of prediabetes (15). Individuals with fasting glucose levels of 95 to 99 mg/dL or 126 to 140 mg/dL completed a second finger stick to assess hemoglobin A1c (HbA1c); HbA1c levels of 5.7% to 6.4% indicated prediabetes and study eligibility (15). Individuals with HbA1c or glucose levels above the indicated ranges were advised to see their physician and excluded from participation.
Potentially eligible participants completed the Physical Activity Readiness Questionnaire; those who answered positively to 1 or more questions were excluded (16). Employees older than 65 receive a separate health plan through the state’s public employee retirement system; they do not routinely complete the biometric screening used for recruitment and were excluded from participation. Individuals were excluded if they had a current diagnosis of type 2 diabetes, were pursuing or recently had weight-loss surgery, were taking medications that modify blood glucose levels, such as metformin or corticosteroids, or were actively participating in a weight-management program. Participants could not be pregnant, breastfeeding, trying to become pregnant, or planning to leave university employment or move from the area within one year of study enrollment.
Participants randomized to the intervention group received the manualized 16-week group-based intervention adapted from the DPP Outcomes Study Lifestyle Balance Program (17,18). The behavioral goals for the program were consistent with those of the DPP: achieve at least 7% weight loss, engage in at least 150 minutes per week of moderate to vigorous PA, and consume 25% or less of total energy from fat (3). The intervention focused on a lower-fat diet, and evidence suggests that reduced-calorie diets can produce clinically meaningful weight loss (19). Groups of 10 to15 participants met for 60 minutes weekly during the lunch hour or after work. Participants were encouraged to attend make-up sessions and obtain a weight measurement if they missed a session. Two university dietitians trained in intervention implementation served as lifestyle coaches for the weekly sessions. Written study materials, a book for estimating fat grams and calorie intake, and booklets for self-monitoring diet and PA were provided to participants. Participants received individual behavioral goals on weight, fat-gram intake, and PA during the first session, and they were encouraged to set small goals each week to facilitate progressive goal attainment. Participants engaged in group discussions and completed individual and group activities to foster skill development and social support. Participants were encouraged to self-monitor diet and PA daily and to submit monitoring booklets weekly for review by the lifestyle coach, who provided individualized feedback.
Participants in the control group received usual care from their health care providers. At baseline they received a booklet developed by the National Diabetes Education Program that describes strategies for self-regulated weight loss (20). Use of these materials is associated with modest weight loss (21). In their written materials, the control group was given a 7% target for weight loss. Following completion of all data collection, control group participants were invited to attend an informational session that addressed key weight-loss principles from the intervention.
A checklist for monitoring adherence to the intervention program was used to ensure fidelity. The principal investigator observed more than 20% of intervention sessions and found no serious departures from the curriculum as planned.
All study measures were collected at baseline, postintervention (4 months), and at 3-month follow-up (7 months). The primary outcome was percentage weight change; secondary outcomes were anthropometric measures (height, waist circumference), clinical measures (glucose, blood lipids, blood pressure), dietary intake, and PA levels. Body weight was measured using a calibrated digital scale (Health-O-Meter Professional). Height was measured at baseline using a standing stadiometer (Perspective Enterprises). For height and weight measurements, participants wore light clothing and removed shoes. Waist circumference was assessed using the National Health and Nutrition Examination Survey protocol (22). Anthropometric measurements were collected twice per visit, and mean values were used for analyses.
Finger-stick blood samples were collected after a minimum 8-hour fast. The Alere Cholestech LDX System (23) was used to complete point-of-care analysis of the blood samples for glucose, total cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides. Low-density lipoprotein (LDL) cholesterol was calculated using the Friedewald equation (24). The Alere Cholestech LDX System was certified as accurate and reproducible by the Centers for Disease Control and Prevention’s Lipid Standardization Program and Cholesterol Reference Method Laboratory Network (23). At each assessment, 2 systolic and 2 diastolic blood pressure readings were collected from seated participants with an Omron Healthcare 7-Series home blood pressure cuff, which meets the protocol criteria for validation standards of the European Society of Hypertension (25).
Dietary intake was estimated from the self-administered full-length Block 2005 Food Frequency Questionnaire (FFQ) (NutritionQuest). Portion sizes ranged from ¼ cup to 2 cups, and a food portion visual aid was provided. Nine response options on frequency of intake were included. PA was assessed using the Lifecorder Plus Accelerometer (Suzuken-Kenz, Inc), which estimates minutes spent in light, moderate, and vigorous PA. Participants were instructed to wear the accelerometer on their hip at the waistline for all waking hours on 7 consecutive days during each assessment.
Between-group differences in baseline demographic characteristics were assessed using Pearson χ2 tests or Fisher exact tests; differences in age were assessed using a 2-sample t test. We developed and validated mixed models in which participants nested within treatment groups were used as random effects, and treatment group, time, and their interaction were used as fixed effects. Outcome variables were assessed in the framework of these models using Student t tests within a repeated measures analysis of variance framework for between-group comparisons of mean values at baseline, and between-group and within-group change from baseline to postintervention and from baseline to 3-month follow-up. Outcome variables with residuals containing skewed distributions were modeled on the logarithmic scale to achieve approximately normal distributions. Relationships between postintervention weight change and intervention participation were assessed using Spearman correlations. Power analysis (power = 0.90, 2-tailed α = .05) for the primary outcome, percentage weight change, based on a previous DPP translational study, indicated that 25 participants in each treatment group were needed to detect a 4.04% difference between groups (21). All analyses were completed using SAS software package JMP version 10 (SAS Institute, Inc).
We found no significant differences in demographic characteristics between eligible individuals who enrolled in the study and those who declined enrollment, except for age (50.6 vs. 44.9 years, respectively; P = .005). We found no significant baseline differences in demographic characteristics between treatment groups, except for occupation (P = .01) (Table 1). Similarly, we found no significant difference between treatment groups at baseline for study outcomes, except for significantly lower diastolic blood pressure in the control than intervention group (P = .04) (Table 2). We found no significant differences in participant characteristics at baseline between those who did and those who did not complete the study (all P > .05).
We found a significant between-group difference in mean (SE) percentage weight change from baseline to postintervention (−5.5% [0.6], intervention; −0.4% [0.5], control; P < .001). Postintervention, the intervention group achieved significantly greater reductions in waist circumference, fasting glucose, and systolic and diastolic blood pressure than did the control group (all P < .025). Total cholesterol declined significantly (P = .01) in the intervention group.
The intervention group had a greater reduction in percentage energy from fat (P = .008) and a greater increase in fiber intake (P = .05) than the control group. In the intervention group postintervention, total energy intake decreased significantly (P < .001); intake of total fats, saturated fats, and trans fats decreased significantly; and carbohydrate and dietary fiber intake increased significantly (all P < .01).
Changes from baseline to 3-month follow-up remained significantly greater for the intervention than the control group for percentage weight change, body weight, waist circumference, and systolic and diastolic blood pressure (all P < .05). HDL cholesterol significantly increased from baseline to 3-month follow-up (P = .002) in the intervention group; this increase was significantly different from that of the control group (P = .04).
Changes in dietary intake and PA from baseline to 3-month follow-up were not significantly different between groups for any outcome. Total energy intake significantly decreased from baseline in the intervention group (P = .002) and control group (P < .001) at study end.
In the intervention group, 32.4% met the goal of achieving 7% or more weight loss postintervention, which was significantly more than in the control group (2.9%; P = .003). The proportion of participants in each group who lost more than 5% of their weight differed postintervention and at 3-month follow-up (Table 3). Fewer than 10% of participants in either group met the dietary goal of consuming 25% or less of total energy intake from fat at any time point. Postintervention, although few participants met the behavioral goal, fat intake had shifted from baseline more in the intervention than in the control group (P = .01).
The mean (standard deviation [SD]) number of sessions attended by intervention participants was 11.6 (4.5) or 72.5% of the 16 sessions offered. Participants recorded their dietary intake for a mean (SD) of 5.6 (1.5) days per week, and reported a mean (SD) of 161.9 (135.0) minutes per week of PA. In the intervention group, the change in body weight postintervention was negatively associated with total days of self-monitoring dietary intake (r = −0.62, P < .001), total minutes spent in PA (r = −0.49, P = .004), and total number of sessions attended (r = −0.60, P < .001).
The 16-week group-based lifestyle intervention delivered at a university worksite facilitated reductions in body weight among employees with prediabetes. These results support the efficacy of the intervention for promoting risk reduction (3) and provide evidence for its utility at the worksite. Whereas 50% of participants who received the original 24-week DPP intervention, which included individual counseling, lost at least 7% of body weight (3), 32.4% of intervention participants in our study lost that amount. The smaller proportion in our study may have resulted from the shorter intervention period and group delivery format. We chose a group delivery format for a worksite approach to reduce personnel demands and enhance employee cohesion and support.
Weight loss in the DPP was the primary predictor of reduction in diabetes incidence; every percentage point of weight loss achieved at the end of the intervention contributed to a 10% reduction in diabetes risk, independent of glycemic changes (26). Mean postintervention weight loss in our study was 5.5%, which is considered clinically significant and is frequently associated with reduced morbidity and mortality (27). An 8-year longitudinal study examined changes in risk factors after a worksite wellness program at a US university and found that obese participants who achieved and maintained a BMI less than 30 kg/m2 for 3 consecutive years reduced the risk of developing type 2 diabetes by 78% compared with those who remained obese (28). Thus, a mean weight loss of 5.5% following the intervention in our study contributes to risk reduction for type 2 diabetes. Long-term follow-up is needed to determine the progression to type 2 diabetes after weight loss.
Fasting glucose values returned to near-normal levels in the intervention group postintervention, and the improvement was maintained at 3-month follow-up. Each 5 mg/dL decrement of fasting glucose at 6 months in the DPP was related to a 26% reduction in diabetes risk (26). We did not assess postload glucose. DPP reports identified the lifestyle intervention as being superior to metformin in restoring normal postload glucose values; however, that was not the case for fasting glucose (3). Further research of worksite translations of the DPP should consider assessing both fasting and postload glucose; however, the assessment of postload glucose increases participant burden and study costs.
PA levels in the intervention group approached the goal of 150 minutes per week postintervention. However, PA returned to near baseline levels after the 3-month maintenance phase. Half of the intervention group achieved the PA goal postintervention, suggesting that this population of primarily working women struggled to initiate and sustain regular PA. The postintervention decline in PA is consistent with findings from other lifestyle interventions documenting that overweight individuals with or at risk for chronic disease often rapidly return to sedentary behavior upon intervention completion (29). However, our findings are in contrast to the DPP, in which 74% of lifestyle participants met the goal immediately after intervention completion, and 67% did 2 years later (30). Working adults may need more support than the general population to increase PA levels. Incentives used in the DPP to keep participants at goal may have been responsible for the higher levels of PA observed (18). Free-of-charge membership to campus exercise facilities might enhance engagement in PA for university worksite studies. A meta-analysis of PA interventions concluded that to be most effective, interventions targeting PA should include self-monitoring, goal setting, and modeling PA behaviors (31). Although our intervention included both PA self-monitoring and goal setting, the findings suggest that greater emphasis on the development and practice of key PA-related self-regulatory skills (ie, goal setting, barrier problem solving, PA planning) necessary to facilitate the transition to independent maintenance of PA may also promote long-term PA adherence.
Study participants reported changes in dietary intake. Total energy intake and percentage energy from fat decreased and fiber intake increased significantly in the intervention group postintervention. Lower fat intake and greater fiber intake in combination with modest weight loss and increased PA was associated with reduced risk for type 2 diabetes among at-risk adults (32,33). Reducing fat intake to less than 30% of energy is associated with preventing weight regain after periods of energy restriction, highlighting the benefits of reduced fat intake for long-term maintenance of weight loss (34).
Energy intake at 3-month follow-up also decreased significantly (P < .001) in the control group. All eligible participants were informed after screening that their glucose values were in the prediabetes range, and the control group received written materials on diet and PA changes to promote weight loss. Knowledge of their own prediabetes may promote behavioral change in at-risk individuals. Additionally, participants may have reported lifestyle changes because of repeated assessment of weight, diet, and PA behaviors, consistent with the Hawthorne effect.
Although results from our study are promising, some limitations exist. Follow-up was limited to 3-months postintervention; thus, long-term outcomes are unknown. A larger translational study with longer follow-up is needed to further evaluate effectiveness in delaying or preventing type 2 diabetes. A worksite approach is promising for tracking disease progression, especially when annual employee biometric screenings are implemented. For worksite adoption, the lifestyle intervention needs to be cost-effective, sustainable, and compatible with existing health care systems. Future research should evaluate the cost-effectiveness and long-term sustainability of worksite translations of the DPP. In our study, 80% of the participants were women, whereas 62% of the benefit-eligible university employees were women. Disparity in enrollment by sex is common in weight-loss studies, and recruitment of men deserves further evaluation. Men may benefit from Internet-based gender-tailored programs (35). Future research should address how best to tailor programs to the interests and needs of men and racial/ethnic minority populations.
Prediabetes is a growing problem in the United States and places individuals at increased risk for type 2 diabetes. Worksites can be effective settings for offering health promotion programs to employees; however, few studies have evaluated the impact of the DPP intervention at the worksite. Our study contributes to the limited evidence and demonstrates, through a randomized design, the feasibility and efficacy of the group-based DPP intervention in facilitating improvement in lifestyle behaviors, weight control, and reduction in metabolic risk for type 2 diabetes among university employees with prediabetes.
Research reported in this publication was supported by the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under award no. R34DK093907. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. ClinicalTrials.gov ID: NCT01682954. Title: Evaluation of a Lifestyle Intervention for Employees with Prediabetes. Date of registration: September 7, 2012. Funding source: National Institute of Diabetes and Digestive and Kidney Diseases.
Corresponding Author: Carla K. Miller, PhD, RD, The Ohio State University, 1787 Neil Ave, 325 Campbell Hall, Columbus, OH 43210. Telephone: 614-292-1391. Email: email@example.com.
Author Affiliations: Kellie R. Weinhold, Haikady N. Nagaraja, Brian C. Focht, The Ohio State University, Columbus, Ohio; David G. Marrero, Indiana University School of Medicine, Indianapolis, Indiana; Gregg M. Gascon, The Ohio State University Health Plan, Inc, Columbus, Ohio.
- Bullard KM, Saydah SH, Imperatore G, Cowie CC, Gregg EW, Geiss LS, et al. Secular changes in U.S. prediabetes prevalence defined by hemoglobin A1c and fasting plasma glucose: National Health and Nutrition Examination Surveys, 1999–2010. Diabetes Care 2013;36(8):2286–93. CrossRef PubMed
- Tabák AG, Herder C, Rathmann W, Brunner EJ, Kivimäki M. Prediabetes: a high-risk state for diabetes development. Lancet 2012;379(9833):2279–90. CrossRef PubMed
- Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002;346(6):393–403. CrossRef PubMed
- Pan XR, Li GW, Hu YH, Wang JX, Yang WY, An ZX, et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care 1997;20(4):537–44. CrossRef PubMed
- Tuomilehto J, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001;344(18):1343–50. CrossRef PubMed
- Knowler WC, Fowler SE, Hamman RF, Christophi CA, Hoffman HJ, Brenneman AT, et al. 10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. Lancet 2009;374(9702):1677–86. CrossRef PubMed
- Schröer S, Haupt J, Pieper C. Evidence-based lifestyle interventions in the workplace — an overview. Occup Med (Lond) 2014;64(1):8–12. CrossRef PubMed
- Goetzel RZ, Pei X, Tabrizi MJ, Henke RM, Kowlessar N, Nelson CF, et al. Ten modifiable health risk factors are linked to more than one-fifth of employer-employee health care spending. Health Aff (Millwood) 2012;31(11):2474–84. CrossRef PubMed
- Jackson L. Translating the Diabetes Prevention Program into practice: a review of community interventions. Diabetes Educ 2009;35(2):309–20. CrossRef PubMed
- Barham K, West S, Trief P, Morrow C, Wade M, Weinstock RS. Diabetes prevention and control in the workplace: a pilot project for county employees. J Public Health Manag Pract 2011;17(3):233–41. CrossRef PubMed
- Giese KK, Cook PF. Reducing obesity among employees of a manufacturing plant: translating the Diabetes Prevention Program to the workplace. Workplace Health Saf 2014;62(4):136–41. CrossRef PubMed
- Aldana S, Barlow M, Smith R, Yanowitz F, Adams T, Loveday L, et al. A worksite diabetes prevention program: two-year impact on employee health. AAOHN J 2006;54(9):389–95. CrossRef PubMed
- Wilson MG, DeJoy DM, Vandenberg R, Padilla H, Davis M. FUEL your life: a translation of the Diabetes Prevention Program to worksites. Am J Health Promot 2015. CrossRef PubMed
- Are you at risk for type 2 diabetes? Diabetes risk test. American Diabetes Association; 2015. http://main.diabetes.org/dorg/PDFs/risk-test-paper-version.pdf. Accessed June 18, 2015.
- American Diabetes Association. (2) Classification and diagnosis of diabetes. Diabetes Care 2015;38(Suppl):S8–16. CrossRef PubMed
- Thomas S, Reading J, Shephard RJ. Revision of the Physical Activity Readiness Questionnaire (PAR-Q). Can J Sport Sci 1992;17(4):338–45. PubMed
- Diabetes Prevention Program curriculum. Atlanta (GA): Centers for Disease Control and Prevention (CDC): National Center for Chronic Disease Prevention and Health Promotion, Division of Diabetes Translation; 2012. http://www.cdc.gov/diabetes/prevention/recognition/curriculum.htm. Accessed November 19, 2014.
- Diabetes Prevention Program (DPP) Research Group. The Diabetes Prevention Program (DPP): description of lifestyle intervention. Diabetes Care 2002;25(12):2165–71. CrossRef PubMed
- Sacks FM, Bray GA, Carey VJ, Smith SR, Ryan DH, Anton SD, et al. Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N Engl J Med 2009;360(9):859–73. CrossRef PubMed
- National Diabetes Education Program. Small steps. Big rewards. Your game plan to prevent type 2 diabetes. http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=71. Accessed August 20, 2014.
- Ackermann RT, Finch EA, Brizendine E, Zhou H, Marrero DG. Translating the Diabetes Prevention Program into the community: the DEPLOY pilot study. Am J Prev Med 2008;35(4):357–63. CrossRef PubMed
- National Health and Nutrition Examination Survey Examination: anthropometry procedures manual. Hyattsville (MD): Centers for Disease Control and Prevention, National Center for Health Statistics; 2011. http://www.cdc.gov/nchs/data/nhanes/nhanes_11_12/Anthropometry_Procedures_Manual.pdf. Accessed August 20, 2014.
- Alere. Alere Cholestech LDX System. http://www.alere.com/us/en/product-details/cholestech-ldx-system.html. Accessed August 20, 2014.
- Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18(6):499–502. PubMed
- Omron Healthcare, Inc. Validation standards and testing for blood pressure monitors. http://omronhealthcare.com/service-and-support/clinical-validation/. Accessed August 20, 2014.
- Maruthur NM, Ma Y, Delahanty LM, Nelson JA, Aroda V, White NH, et al. Early response to preventive strategies in the Diabetes Prevention Program. J Gen Intern Med 2013;28(12):1629–36. CrossRef PubMed
- Jensen MD, Ryan DH, Apovian CM, Ard JD, Comuzzie AG, Donato KA, et al. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. Circulation 2014;129(25 Suppl 2):S102–38. Erratum in Circulation 2014;129(25 Suppl 2):S139–40. CrossRef PubMed
- Rolando L, Byrne DW, McGown PW, Goetzel RZ, Elasy TA, Yarbrough MI. Health risk factor modification predicts incidence of diabetes in an employee population: results of an 8-year longitudinal cohort study. J Occup Environ Med 2013;55(4):410–5. CrossRef PubMed
- Wing RR, Venditti E, Jakicic JM, Polley BA, Lang W. Lifestyle intervention in overweight individuals with a family history of diabetes. Diabetes Care 1998;21(3):350–9. CrossRef PubMed
- Wing RR, Hamman RF, Bray GA, Delahanty L, Edelstein SL, Hill JO, et al. Achieving weight and activity goals among Diabetes Prevention Program lifestyle participants. Obes Res 2004;12(9):1426–34. CrossRef PubMed
- Conn VS, Hafdahl AR, Mehr DR. Interventions to increase physical activity among healthy adults: meta-analysis of outcomes. Am J Public Health 2011;101(4):751–8. CrossRef PubMed
- Jaacks LM, Ma Y, Davis N, Delahanty LM, Mayer-Davis EJ, Franks PW, et al. Long-term changes in dietary and food intake behaviour in the Diabetes Prevention Program Outcomes Study. Diabet Med 2014;31(12):1631–42. CrossRef PubMed
- Roumen C, Corpeleijn E, Feskens EJ, Mensink M, Saris WH, Blaak EE. Impact of 3-year lifestyle intervention on postprandial glucose metabolism: the SLIM study. Diabet Med 2008;25(5):597–605. CrossRef PubMed
- Leser MS, Yanovski SZ, Yanovski JA. A low-fat intake and greater activity level are associated with lower weight regain 3 years after completing a very-low-calorie diet. J Am Diet Assoc 2002;102(9):1252–6. CrossRef PubMed
- Morgan PJ, Callister R, Collins CE, Plotnikoff RC, Young MD, Berry N, et al. The SHED-IT community trial: a randomized controlled trial of internet- and paper-based weight loss programs tailored for overweight and obese men. Ann Behav Med 2013;45(2):139–52. CrossRef PubMed
Table 1. Demographic Characteristics of Participants in a Diabetes Prevention Study at a University Worksite, by Treatment Group at Baseline, 2012–2014a
|Characteristic||Intervention (n = 35)||Control (n = 34)||P Value|
|Age, mean (SD), y||51.6 (9.5)||51.0 (8.1)||.50b|
|White||27 (77.1)||30 (88.2)||.34c|
|Asian or black||8 (22.9)||4 (11.8)|
|Non-Hispanic||35 (100.0)||33 (97.1)||.49c|
|Male||7 (20.0)||7 (20.6)||>.99c|
|Female||28 (80.0)||27 (79.4)|
|Less than bachelor’s degree||15 (42.9)||9 (26.5)||.32d|
|Bachelor’s degree||11 (31.4)||12 (35.3)|
|Postgraduate degree||9 (25.7)||13 (38.2)|
|Full-time employment||32 (91.4)||33 (97.1)||.61c|
|Part-time employment||3 (8.6)||1 (2.9)|
|Married||24 (68.6)||26 (76.5)||.59c|
|Not married||11 (31.4)||8 (23.5)|
|Professional||12 (35.3)||19 (55.9)||.01d|
|Clerical||10 (29.4)||13 (38.2)|
|Other||12 (35.3)||2 (5.9)|
|Years at current job|
|1–5||13 (37.1)||11 (32.4)||.27d|
|6–10||13 (37.1)||7 (20.6)|
|11–15||3 (8.6)||6 (17.7)|
|=16||6 (17.1)||10 (29.4)|
|Nonstudent||30 (85.7)||32 (94.1)||.22d|
|Full-time student||3 (8.6)||0|
|Part-time student||2 (5.7)||2 (5.9)|
|Number of people in the household|
|1||5 (14.3)||2 (5.9)||.64d|
|2||17 (48.6)||16 (47.1)|
|3||6 (17.1)||5 (14.7)|
|4||5 (14.3)||9 (26.5)|
|=5||2 (5.7)||2 (5.9)|
|Annual household incomee, $|
|20,000–39,999||8 (23.5)||3 (8.8)||.22d|
|40,000–59,999||4 (11.8)||4 (11.8)|
|60,000–79,999||6 (17.7)||6 (17.6)|
|80,000–99,999||9 (26.5)||6 (17.6)|
|=100,000||7 (20.6)||15 (44.1)|
Table 2. Changes in Anthropometric, Clinical, Dietary, and Physical Activity Outcomes of Participants in a Diabetes Prevention Study at a University Worksite, by Treatment Group at Baseline, 4 Months, and 7 Months, 2012–2014
|Outcome||ANOVA Model Effects||Timea||Intervention, Mean (SE) (n = 35)b||Control, Mean (SE) (n = 34)b||P Valuec|
|Time||Group||Group × Time|
|Weight change, %d||—||—||—||Baseline||—||—||—|
|4 Months||-5.5 (0.6)||-0.4 (0.5)||<.001|
|7 Months||-5.2 (1.0)||-0.2 (0.7)||<.001|
|Body weight, kg||<.001||.02||<.001||Baseline||95.4 (2.9)||101.9 (2.9)||.12|
|4 Months||-5.1 (0.6)||-0.4 (0.6)||<.001|
|7 Months||-4.9 (0.6)||-0.4 (0.6)||<.001|
|Body mass index, kg/m2||<.001||.15||<.001||Baseline||35.0 (1.0)||35.9 (1.0)||.53|
|4 Months||-1.9 (0.2)||-0.1 (0.2)||<.001|
|7 Months||-1.7 (0.2)||-0.1 (0.2)||<.001|
|Waist circumference, cm||<.001||.04||.01||Baseline||107.2 (2.0)||110.8 (2.0)||.21|
|4 Months||-4.8 (0.9)||-1.3 (0.9)||.007|
|7 Months||-5.1 (0.9)||-2.1 (0.9)||.02|
|Fasting glucose, mg/dL||<.001||.11||.05||Baseline||108.9 (1.8)||110.8 (1.9)||.52f|
|4 Months||-8.6 (1.6)||-3.7 (1.6)||.02f|
|7 Months||-8.2 (1.5)||-7.5 (1.6)||.69f|
|Total cholesterol, mg/dL||.01||.42||.06||Baseline||194.7 (4.7)||197.8 (4.8)||.64|
|4 Months||-11.3 (4.4)||-1.6 (4.4)||.12|
|7 Months||5.7 (4.4)||0.4 (4.5)||.40|
|LDL cholesterol, mg/dL||.08||.34||.21||Baseline||112.6 (4.1)||114.5 (4.2)||.75|
|4 Months||-9.1 (4.2)||-0.2 (4.2)||.13|
|7 Months||2.1 (4.0)||1.6 (4.2)||.93|
|HDL cholesterol, mg/dL||.06||.40||.06||Baseline||50.9 (2.5)||50.5 (2.5)||.71f|
|4 Months||-0.04 (1.4)||-0.3 (1.4)||.95f|
|7 Months||4.1 (1.4)||-0.3 (1.4)||.04f|
|Triglycerides, mg/dL||.24||.98||.99||Baseline||166.1 (13.1)||163.0 (13.4)||.99f|
|4 Months||-8.0 (9.3)||-4.8 (9.3)||.92f|
|7 Months||-12.9 (9.1)||-3.0 (9.4)||.98f|
|Systolic blood pressure, mm Hg||.02||.85||.02||Baseline||128.8 (2.4)||124.4 (2.4)||.21|
|4 Months||-8.3 (2.2)||-0.4 (2.2)||.01|
|7 Months||-6.3 (2.1)||0.4 (2.2)||.03|
|Diastolic blood pressure, mm Hg||<.001||.95||<.001||Baseline||90.9 (1.6)||86.2 (1.6)||.04|
|4 Months||-8.5 (1.2)||-1.8 (1.3)||<.001|
|7 Months||-7.5 (1.2)||-0.6 (1.3)||<.001|
|Total energy, kcal||<.001||.10||.13||Baseline||1,797 (117)||1,903 (120)||.26f|
|4 Months||-424 (99)||-183 (101)||.12f|
|7 Months||-318 (97)||-309 (100)||.73f|
|Protein, % of total energy||.56||.73||.11||Baseline||15.8 (0.4)||14.9 (0.4)||.13|
|4 Months||-0.3 (0.4)||1.0 (0.4)||.05|
|7 Months||-0.3 (0.4)||0.7 (0.4)||.12|
|Fat, % of energy||.30||.14||.007||Baseline||36.7 (1.0)||37.6 (1.1)||.54|
|4 Months||-2.6 (0.8)||0.8 (0.9)||.008|
|7 Months||-0.1 (0.8)||-0.2 (0.9)||.88|
|Saturated fat, g/1,000 kcal||.02||.09||.006||Baseline||12.6 (0.5)||13.3 (0.5)||.32|
|4 Months||-1.5 (0.4)||-0.1 (0.4)||.01|
|7 Months||-0.3 (0.4)||-0.6 (0.4)||.57|
|Trans fat, g/1,000 kcal||.02||.11||.30||Baseline||1.3 (0.1)||1.4 (0.1)||.48|
|4 Months||-0.2 (0.1)||-0.05 (0.1)||.13|
|7 Months||-0.1 (0.06)||-0.1 (0.1)||.53|
|Monounsaturated fat, g/1,000 kcal||.63||.19||.03||Baseline||16.2 (0.5)||16.5 (0.5)||.67|
|4 Months||-1.0 (0.5)||0.6 (0.5)||.02|
|7 Months||0.2 (0.5)||0.2 (0.5)||.97|
|Polyunsaturated fat, g/1,000 kcal||.48||.70||.53||Baseline||8.9 (0.3)||8.8 (0.3)||.89|
|4 Months||-0.17 (0.3)||0.3 (0.3)||.27|
|7 Months||0.2 (0.3)||0.3 (0.3)||.75|
|Carbohydrate, % of total energy||.14||.31||.002||Baseline||46.7 (1.3)||46.8 (1.3)||.96|
|4 Months||3.7 (1.0)||-1.0 (1.0)||<.001|
|7 Months||0.6 (1.0)||-0.04 (1.0)||.62|
|Fiber, g/1,000 kcal||<.001||.50||.06||Baseline||10.5 (0.6)||10.0 (0.6)||.87f|
|4 Months||2.2 (0.5)||0.9 (0.5)||.05f|
|7 Months||0.8 (0.4)||1.2 (0.5)||.87f|
|Total sugars, g/1,000 kcal||.47||.34||.06||Baseline||51.6 (2.8)||52.5 (2.9)||.84|
|4 Months||6.8 (2.8)||-2.4 (2.8)||.02|
|7 Months||3.6 (2.7)||0.4 (2.8)||.41|
|Moderate/vigorous intensity physical activity, total minutes per week||.34||.28||.20||Baseline||122.6 (14.8)||106.9 (15.3)||.80f|
|4 Months||23.9 (12.0)||2.2 (12.4)||.08f|
|7 Months||6.8 (11.9)||9.9 (12.2)||.29f|
Table 3. Attainment of Program Goals Among Intervention and Control Participants in a Diabetes Prevention Study at a University Worksite, by Treatment Group at Baseline, 4 Months, and 7 Months, 2012–2014a
|Program Goal||Baseline||4 Months (Postintervention)||7 Months (3-Month Follow-Up)|
|Intervention (n = 35)||Control (n = 34)||Pb||Intervention (n = 34)c||Control (n = 34)c||Pb||Intervention (n = 35)||Control (n = 33)||Pb|
|>5% Weight loss||—||—||—||18 (52.9)||1 (2.9)||<.001||17 (48.6)||3 (9.1)||<.001|
|0%–5% Weight loss||—||—||—||14 (41.2)||17 (50.0)||13 (37.1)||12 (36.4)|
|Weight gain||—||—||—||2 (5.9)||16 (47.1)||5 (14.3)||18 (54.5)|
|150 Min/wk MVPA||10 (28.6)||8 (23.5)||.79d||17 (50.0)||8 (25.0)||.05d||12 (34.3)||9 (27.3)||.60d|
|<30% Energy from fat||3 (8.6)||2 (5.9)||.87||13 (39.4)||3 (9.4)||.01||6 (17.1)||1 (3.0)||.13|
|30%–35% Energy from fat||8 (22.9)||7 (20.6)||6 (18.2)||5 (15.6)||6 (17.1)||9 (27.3)|
|>35% Energy from fat||24 (68.6)||25 (73.5)||14 (42.4)||24 (75.0)||23 (65.7)||23 (69.7)|
To obtain credit, you should first read the journal article. After reading the article, you should be able to answer the following, related, multiple-choice questions. To complete the questions (with a minimum 75% passing score) and earn continuing medical education (CME) credit, please go to http://www.medscape.org/journal/pcd. Credit cannot be obtained for tests completed on paper, although you may use the worksheet below to keep a record of your answers. You must be a registered user on Medscape.org. If you are not registered on Medscape.org, please click on the "Register" link on the right hand side of the website to register. Only one answer is correct for each question. Once you successfully answer all post-test questions you will be able to view and/or print your certificate. For questions regarding the content of this activity, contact the accredited provider, CME@medscape.net. For technical assistance, contact CME@webmd.net. American Medical Association’s Physician’s Recognition Award (AMA PRA) credits are accepted in the US as evidence of participation in CME activities. For further information on this award, please refer to http://www.ama-assn.org/ama/pub/about-ama/awards/ama-physicians-recognition-award.page. The AMA has determined that physicians not licensed in the US who participate in this CME activity are eligible for AMA PRA Category 1 Credits™. Through agreements that the AMA has made with agencies in some countries, AMA PRA credit may be acceptable as evidence of participation in CME activities. If you are not licensed in the US, please complete the questions online, print the AMA PRA CME credit certificate and present it to your national medical association for review.
Article Title: A Randomized Controlled Trial Translating the Diabetes Prevention Program to a University Worksite, Ohio, 2012–2014
- You are consulting for a large health maintenance organization regarding use of a worksite lifestyle intervention for employees with prediabetes. Which of the following statements about the worksite lifestyle intervention used in the randomized trial by Weinhold and colleagues is correct?
- The intervention was adapted from the Diabetes Prevention Program Outcomes Study Lifestyle Balance Program
- The intervention focused on a lower-carbohydrate diet
- Groups of 10 to 15 participants met for 30 minutes weekly for 12 weeks during the lunch hour or in the evening after work
- Participants received daily diet and physical activity self-monitoring booklets and submitted them daily for review by the lifestyle coach
- According to the randomized trial by Weinhold and colleagues, which of the following statements about the efficacy of a worksite lifestyle intervention for improving metabolic risk factors among employees with prediabetes is correct?
- Mean weight loss was 3% in the intervention group and 2% in the control group after the intervention
- Weight loss in the intervention group was not sustained at 3-month follow-up
- Mean fasting glucose reductions were not significantly greater in the intervention group than in the control group
- Both groups had significant glucose reductions at 3-month follow-up (P <.001)
- According to the randomized trial by Weinhold and colleagues, which of the following statements about the efficacy of a worksite lifestyle intervention for improving behavioral risk factors among employees with prediabetes would most likely be correct?
- Postintervention, total energy and percent energy from total, saturated, and trans fats did not decrease significantly in the intervention group
- Postintervention, dietary fiber did not increase significantly in the intervention group
- Behavioral goals were to achieve at least 7% weight loss, obtain at least 150 minutes per week of moderate to vigorous physical activity, and consume 25% or less of total energy from fat
- The study proves that the workplace intervention improves behavioral risk factors and sustains improvement over the long-term
|1. The activity supported the learning objectives.|
|Strongly Disagree||Strongly Agree|
|2. The material was organized clearly for learning to occur.|
|Strongly Disagree||Strongly Agree|
|3. The content learned from this activity will impact my practice.|
|Strongly Disagree||Strongly Agree|
|4. The activity was presented objectively and free of commercial bias.|
|Strongly Disagree||Strongly Agree|
- Page last reviewed: November 25, 2015
- Page last updated: November 25, 2015
- Content source: