Frequently Asked Questions About Shingrix
Shingrix is the preferred shingles vaccine. You and patients should make every effort to ensure that two doses are administered within the recommended 2-6 month interval. If more than 6 months have elapsed since the first dose, administer the second dose as soon as possible. Do not restart the vaccine series, and do not substitute Zostavax® (zoster vaccine live) for the second dose of Shingrix. If you are out of Shingrix and a patient needs a second dose, the Vaccine Finderexternal icon may be helpful for patients to locate other providers who have Shingrix.
- How should I administer Shingrix?
- Do I need to reconstitute Shingrix?
- Where should I store Shingrix?
- How many doses of Shingrix do I give?
- How long should I wait after giving the first dose of Shingrix to give the second dose?
- What should I do if a patient waits longer than 6 months to get the second dose?
- How long after a person received Zostavax should I wait to give Shingrix?
- How long after a person received chickenpox vaccine should I wait to give Shingrix?
- Can I give Shingrix with other adult vaccines?
- Can Shingrix be administered to immunocompromised individuals?
- What are the primary differences between Shingrix and Zostavax?
A: You should give the second dose as soon as possible. However, you do not need to restart the vaccine series.
Everything You Need to Know About Shingrixexternal icon
Dr. Kathleen Dooling discusses storage, administration, and patient counseling for the new shingles vaccine
Q: How long after a person received Zostavax—the shingles vaccine in use since 2006—should I wait to give Shingrix?
A: Studies confirmed that Shingrix was safe and immunogenic when administered 5 or more years after Zostavax. Intervals shorter than 5 years have not been studied. However, there are no data or theoretical concerns to indicate Shingrix would be less safe or effective when given less than 5 years after Zostavax. You may consider an interval shorter than 5 years, especially if your patient was >70 years old when they received Zostavax. Wait a minimum of 8 weeks after a person received Zostavax to give Shingrix.
|Characteristic||Shingrix (recombinant zoster vaccine [RZV], GlaxoSmithKline [GSK])||Zostavax (zoster vaccine live [ZVL], Merck)|
|Vaccine Type||Inactivated recombinant, adjuvanted (non-live)||Live attenuated|
|Vaccine Composition||Supplied as 2 components:
||Supplied as 2 components: