April 22, 2024

Clinical Guidelines

This page provides a list of selected clinical guidelines related to tuberculosis (TB) topics. Guidelines are sorted by topics: testing and diagnosis, treatment, drug resistance, infection control, TB and HIV, specific populations, and vaccines.

Healthcare provider looking at computer monitor

Testing and Diagnosis

TB testing and diagnosis guidelines by publication date
Title	Year Published
Diagnosis of Tuberculosis in Children and Adults Clinical Infectious Disease 2017 Executive Summary Full Guidelines	2017
Availability of an Assay for Detecting Mycobacterium tuberculosis, Including Rifampin-Resistant Strains, and Considerations for Its Use — United States, 2013 MMWR 2013; 62 (No. 41)	2013
National Shortage of Purified-Protein Derivative Tuberculin Products MMWR 2013; 62 (No. 16)	2013
Report of an Expert Consultation on the Uses of Nucleic Acid Amplification Tests for the Diagnosis of Tuberculosis	2012
Updated Guidelines for Using Interferon Gamma Release Assays to Detect Mycobacterium tuberculosis Infection — United States, 2010 MMWR 2010; 59 (RR-5); 1-25	2010
Updated Guidelines for the Use of Nucleic Acid Amplification Tests in the Diagnosis of Tuberculosis MMWR 2009; 58 (01); 7-10	2009
Guidelines for Using the QuantiFERON-TB Gold Test for Detecting Mycobacterium tuberculosis Infection, United States MMWR 2005; 54 (No. RR-15, 49-55)	2005
Guidelines for the Investigation of Contacts of Persons with Infectious Tuberculosis: Recommendations from the National Tuberculosis Controllers Association and CDC MMWR 2005; 54 (No. RR-15, 1-37)	2005
Tuberculosis Associated with Blocking Agents Against Tumor Necrosis Factor – Alpha California, 2002–2003 – MMWR 2004; 53 (No. 30)	2004
Timing of Tuberculosis Screening and Smallpox Vaccination – Recommendations for Using Smallpox Vaccine in a Pre-Event Vaccination Program MMWR 2003; 52 (No. RR-7)	2003
Targeted Tuberculin Testing and Treatment of Latent Tuberculosis Infection MMWR 2000; 49 (No. RR-6)	2000
Diagnostic Standards / Classification of TB in Adults and Children Am J Respir Crit Care Med 2000; 161	1999
The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in the United States. (ACET and ACIP) MMWR 1996; 45 (No. RR-4)	1996

Treatment

TB treatment guidelines by publication date
Title	Year Published
Provisional CDC Guidance for the Use of Pretomanid as part of a Regimen [Bedaquiline, Pretomanid, and Linezolid (BPaL)] to Treat Drug-Resistant Tuberculosis Disease	2023
Recommendations for Use of Video Directly Observed Therapy During Tuberculosis Treatment — United States, 2023. MMWR Morb Mortal Wkly Rep, 2023 Supplemental Information for Video Directly Observed Therapy (vDOT) Recommendations	2023
Interim Guidance: 4-Month Rifapentine-Moxifloxacin Regimen for the Treatment of Drug-Susceptible Pulmonary Tuberculosis — United States, 2022. MMWR Morb Mortal Wkly Rep, 2022	2022
Guidelines for the Treatment of Latent Tuberculosis Infection: Recommendations from the National Tuberculosis Controllers Association and CDC, 2020 MMWR Recomm Rep 2020; 69(No. RR-1): 1-11.	2020
Treatment of Drug-Resistant Tuberculosis American Journal of Respiratory and Critical Care Medicine, 2019 Full Guidelines	2019
Update of Recommendations for Use of Once-Weekly Isoniazid-Rifapentine Regimen to Treat Latent Mycobacterium tuberculosis Infection MMWR 2018;67:723-726	2018
Treatment of Drug-Susceptible Tuberculosis Executive Summary Full Guidelines Clinical Infectious Disease 2016 Table 3. Doses of Antituberculosis Drugs for Adults and Children Highlights from the 2016 Treatment of Drug-Susceptible Tuberculosis Guidelines	2016
Provisional CDC Guidelines for the Use and Safety Monitoring of Bedaquiline Fumarate (Sirturo) for the Treatment of Multidrug-Resistant Tuberculosis MMWR 2013;62 (No. 9)	2013
Managing Drug Interactions in the Treatment of HIV-Related Tuberculosis June 2013	2013
Guidelines for the Investigation of Contacts of Persons with Infectious Tuberculosis: Recommendations from the National Tuberculosis Controllers Association and CDC MMWR 2005; 54 (No. RR-15, 1-37)	2005
Tuberculosis Associated with Blocking Agents Against Tumor Necrosis Factor – Alpha – California, 2002–2003 MMWR 2004; 53 (No. 30)	2004
Notice to Readers: Updated Guidelines for the Use of Rifamycins for the Treatment of Tuberculosis Among HIV-Infected Patients Taking Protease Inhibitors or Nonnucleoside Reverse Transcriptase Inhibitors MMWR 2004; 53 (No. 2)	2004
Update: Adverse Event Data and Revised American Thoracic Society/CDC Recommendations Against the Use of Rifampin and Pyrazinamide for Treatment of Latent Tuberculosis Infection MMWR 2003; 52 (No. 31).	2003

Drug-Resistant TB

Drug-resistant TB guidelines by publication date
Title	Year Published
Provisional CDC Guidance for the Use of Pretomanid as part of a Regimen [Bedaquiline, Pretomanid, and Linezolid (BPaL)] to Treat Drug-Resistant Tuberculosis Disease	2023
Treatment of Drug-Resistant Tuberculosis American Journal of Respiratory and Critical Care Medicine, 2019 Executive Summary Full Guidelines	2019
Provisional CDC Guidelines for the Use and Safety Monitoring of Bedaquiline Fumarate (Sirturo) for the Treatment of Multidrug-Resistant Tuberculosis MMWR 2013; 62 (No. 9)	2013
Availability of an Assay for Detecting Mycobacterium tuberculosis, Including Rifampin-Resistant Strains, and Considerations for Its Use — United States, 2013 MMWR 2013; 62 (No. 41)	2013
Report of Expert Consultations on Rapid Molecular Testing to Detect Drug-Resistant Tuberculosis in the United States	2008
Plan to Combat Extensively Drug-Resistant Tuberculosis MMWR 2009; 58 (RR-03)	2009
Targeted Tuberculin Testing and Treatment of Latent Tuberculosis Infection MMWR 2000; 49 (No. RR-6)	2000

Infection Control and Prevention

TB infection control and prevention guidelines by publication date
Title	Year Published
Tuberculosis Screening Testing, and Treatment of U.S. Health Care Personnel: Recommendations from the National Tuberculosis Controllers Association and CDC, 2019. Baseline Individual TB Risk Assessment Form TB Screening and Testing of Health Care Personnel	2019
Guidelines for Preventing the Transmission of Mycobacterium tuberculosis in Health-Care Settings, 2005 MMWR 2005; 54 (No. RR-17) Reprint Note: The errata was removed. The corrections included in the errata have been incorporated into the reprinted guidelines. The recommendation for screening, testing, and treatment of U.S. health care personnel were updated in 2019. Please see the above recommendations. Additional FAQ’s for Clarification of Recommendations in the Guidelines Appendix B. Tuberculosis (TB) Risk Assessment Worksheet	2005
Guidelines for Environmental Infection Control in Health-Care Facilities MMWR 2003; 52 (No. RR-10)	2003
The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in the United States. (ACET and ACIP). MMWR 1996; 45 (No. RR-4)	1996

TB and HIV

TB and HIV guidelines by publication date
Title	Year Published
Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV
Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents: Mycobacterium tuberculosis Infection and Disease
Guidelines for the Prevention and Treatment of Opportunistic Infections in Children with and Exposed to HIV
Managing Drug Interactions in the Treatment of HIV-Related Tuberculosis	2013
Notice to Readers: Updated Guidelines for the Use of Rifamycins for the Treatment of Tuberculosis Among HIV-Infected Patients Taking Protease Inhibitors or Nonnucleoside Reverse Transcriptase Inhibitors MMWR 2004; 53 (No. 2)	2004

TB in Specific Populations

TB in specific populations guidelines by publication date
Title	Year Published
Diagnosis, Treatment, and Prevention of Tuberculosis Among People Experiencing Homelessness in the United States: Current Recommendations. Public Health Reports. 2023;0(0).	2023
Prevention and Control of Tuberculosis in Correctional and Detention Facilities: Recommendations from CDC MMWR 2006; 55 (No. RR–09, 1–44)	2006
Recommendations for Prevention and Control of Tuberculosis among Foreign-Born Persons MMWR 1998; 47 (No. RR-16)	1998

Vaccines and Immunizations

Vaccines and immunizations guidelines by publication date
Title	Year Published
General Recommendations on Immunization: Recommendations of the Advisory Committee on Immunization Practices (ACIP) and the American Academy of Family Physicians (AAFP) MMWR 2002; 51 (No. RR-2).	2002
Development of New Vaccines for Tuberculosis MMWR 1998; 47 (No. RR-13)	1998
The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in the United States. (ACET and ACIP) MMWR 1996; 45 (RR-4)	1996

Resources

Archived CDC guidelines are available in CDC Stacks

Tuberculosis Guidance for Public Health Professionals

CDC Recommendations for Correctional and Detention Settings

National Tuberculosis Coalition of America Resources

April 22, 2024

Sources Print Share

Content Source:

Division of Tuberculosis Elimination ; National Center for HIV, Viral Hepatitis, STD, and Tuberculosis Prevention; Centers for Disease Control and Prevention

Clinical Guidelines

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