U.S. National Action Plan for Combating Antibiotic-Resistant Bacteria (National Action Plan)

Published March 2015

The National Action Plan directs federal agencies to accelerate response to antibiotic resistance, and has pushed transformative improvements across the country that strengthen and expand the ability to prevent, identify, and respond to these threats.

Although the main purpose is to guide U.S. government activities, the National Action Plan is also designed to guide action by public health, healthcare, and veterinary partners in a common effort to address urgent and serious antibiotic-resistant threats that affect people in the U.S. and around the world.

The National Action Plan was developed by the Interagency Task Force for Combating Antibiotic-Resistant Bacteria in response to Executive Order 13676. It details specific steps and milestones to implement the U.S. National Strategy for Combating Antibiotic-Resistant Bacteria while also addressing the policy recommendations from the President’s Council of Advisors on Science and Technology.

The effort to combat resistant bacteria will become an international priority for global health security.

National Action Plan

Five-year Plan

The National Action Plan provides a five-year plan to reduce antibiotic resistance by:

  • Encouraging innovation and research for new prevention strategies
  • Increasing and enhancing surveillance
  • Adopting of evidence-based stewardship strategies

Main Goals

The National Action Plan supports the five main goals identified in the National Strategy to guide collaborative action taken by the U.S. government:

  • Slow the emergence of resistant bacteria and prevent the spread of resistant infections
  • Strengthen national One Health surveillance efforts to combat resistance
  • Advance development and use of rapid and innovative diagnostic tests for identification and characterization of resistant bacteria
  • Accelerate basic and applied research and development for new antibiotics, other therapeutics, and vaccines
  • Improve international collaboration and capacities for antibiotic resistance prevention, surveillance, control, and antibiotic research and development

Anticipated Results

The National Action Plan will result in the following:

  • Improved antibiotic stewardship in healthcare settings
  • Prevention of the spread of antibiotic-resistant threats
  • Elimination of the use of medically-important antibiotics for growth promotion in food animals
  • Expanded surveillance for antibiotic-resistant bacteria in humans and animals
  • Creation of a regional public health laboratory network
  • Establishment of a specimen repository and sequence database that can be accessed by industrial and academic researchers, development of new diagnostic tests

CDC is addressing its role in accomplishing these goals through its Antibiotic Resistance Solutions Initiative.