National Infection & Death Estimates for Antibiotic Resistance

More than 2.8 million antibiotic-resistant infections occur in the U.S. each year. More than 35,000 people die as a result, according to CDC’s 2019 Antibiotic Resistance (AR) Threats Report. When Clostridioides difficile—a bacterium that is not typically resistant but can cause deadly diarrhea and is associated with antibiotic use—is added to these, the U.S. toll of all the threats in the report exceeds 3 million infections and 48,000 deaths.

The estimated national cost to treat infections caused by six multidrug-resistant germs frequently found in health care can be substantial—more than $4.6 billion annually, according to a collaborative CDC studyexternal icon.

CDC is concerned about the emergence and spread of new forms of resistance and rising resistant infections in the community (outside hospitals). Community infections can put more people at risk, make spread more difficult to identify and contain, and threaten the progress made to protect patients in hospitals.

Dedicated prevention and infection control efforts in the U.S. have reduced deaths from antibiotic-resistant infections by 18% overall and by nearly 30% in hospitals. However, the number of people facing antibiotic resistance is still too high. More action is needed to protect people.