Diphtheria, Tetanus, and Pertussis Vaccine Safety
Diphtheria, tetanus, and pertussis are three bacterial diseases that can be vaccinated against with a single shot.
- Diphtheria causes a thick covering in the back of the throat. It can lead to breathing problems, paralysis, heart failure, and even death.
- Tetanus (lockjaw) is a serious disease that causes painful tightening of the muscles, usually all over the body. It can lead to “locking” of the jaw so the victim cannot open their mouth or swallow. Tetanus leads to death in about 1 in 10 cases.
- Whooping cough — known medically as pertussis — is a highly contagious respiratory tract infection. Although it initially resembles an ordinary cold, whooping cough may eventually turn more serious, particularly in infants.
You can protect against these diseases with safe, effective vaccination. These vaccines include:
- DTaP (diphtheria, tetanus, and acellular pertussis), which is given to children
- Td (adult tetanus and diphtheria), which is given to adolescents and adults
- Tdap (combined tetanus, diphtheria and pertussis), which is given to adolescents and adults
DTaP, Td, and Tdap vaccines are very safe and effective at preventing diphtheria, tetanus, and pertussis. Vaccines, like any medicine, can have side effects. The most common side effects are usually mild and go away on their own.
- Soreness or swelling where the shot was given
- Feeling tired
- Loss of appetite
- Pain, redness, or swelling where the shot was given
- Mild fever
- Pain, redness, or swelling where the shot was given
- Mild fever
- Feeling tired
- Nausea, vomiting, diarrhea, stomach ache
On very rare occasions, severe (anaphylactic) allergic reactions may occur after vaccination, including hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, and weakness.
DTaP (for younger children):
- Daptacel Cdc-pdf[PDF – 336 KB]External: The Food and Drug Administration (FDA) approved this vaccine in 2002. It is approved for use in children who are 6 weeks through 6 years of age to protect against diphtheria, tetanus, and pertussis.
- Infanrix Cdc-pdf[PDF – 210 KB]External: FDA approved this vaccine in 1997. It is approved for use in children who are 6 weeks through 7 years of age to protect against diphtheria, tetanus, and pertussis.
- Kinrix Cdc-pdf[PDF – 165 KB]External: FDA approved this vaccine in 2008. It is approved for use in children who are 4 to 6 years of age to protect against diphtheria, tetanus, pertussis, and polio.
- Pediarix Cdc-pdf[PDF – 242 KB]External: FDA approved this vaccine in 2002. It is approved for use in children who are 6 weeks through 6 years of age to protect against diphtheria, tetanus, pertussis, polio, and hepatitis B.
- Pentacel Cdc-pdf[PDF – 325 KB]External: FDA approved this vaccine in 2008. It is approved for use in children who are 6 weeks through 18 months of age to protect against diphtheria, tetanus, pertussis, Haemophilus Influenzae type B (Hib), and polio.
- Quaracel Cdc-pdf[PDF – 178 KB]External: FDA approved this vaccine in 2015. It is approved for use in children who are 4 through 6 years of age to protect against diphtheria, tetanus, pertussis, and polio.
- There is also a generic Cdc-pdf[PDF – 106 KB]External vaccine to protect against diphtheria and tetanus in children through 6 years of age. It was approved by FDA in 1978.
Td (for adolescents and adults):
- Decavac Cdc-pdf[PDF – 276 KB]External: FDA approved this vaccine in 1955. It is approved for use in people 7 years of age and older to protect against diphtheria and tetanus.
- Tenivac Cdc-pdf[PDF – 304 KB]External: FDA approved this vaccine in 2003. It is approved for use in people 7 years of age and older to protect against diphtheria and tetanus.
- There is also a generic Cdc-pdf[PDF – 65 KB]External vaccine to protect against diphtheria and tetanus in people 7 years of age and older. It was approved by FDA in 1967.
Tdap (for adolescents and adults):
- Boostrix Cdc-pdf[PDF – 316 KB]External: FDA approved this vaccine in 2005. It is approved for use in people 10 years of age and older to protect against diphtheria, tetanus, and pertussis.
- Adacel Cdc-pdf[PDF – 245 KB]External: FDA approved this vaccine in 2005. It is approved for use in people 10 through 64 years of age to protect against diphtheria, tetanus, and pertussis.
CDC and FDA continuously monitor the safety of vaccines after they are approved. If a problem is found with a vaccine, CDC and FDA will inform health officials, health care providers, and the public.
CDC uses three systems to monitor vaccine safety:
- The Vaccine Adverse Event Reporting System (VAERS): an early warning system that helps CDC and FDA monitor problems following vaccination. Anyone can report possible vaccine side effects to VAERS.
- The Vaccine Safety Datalink (VSD): a collaboration between CDC and nine health care organizations which allows ongoing monitoring and proactive searches of vaccine-related data.
- The Clinical Immunization Safety Assessment (CISA) Project: a partnership between CDC and several medical centers that conducts clinical research on vaccine-associated health risks.
DTaP (younger children)
- DTaP studies among VAERS reports found no health concerns related to the vaccine.
- Several studies of DTaP vaccine safety have looked for neurologic problems or seizures after children were vaccinated, and found that there is no increased risk for these concerns.
- DTaP may frequently cause mild injection site reactions. However, severe reactions are rare, and may be less frequent when the vaccine is injected into the leg than into the arm. Reactions happen about as often when DTaP is combined with other vaccines.
Tdap (adolescents and adults)
- Tdap safety studies among VAERS reports have found no safety concerns for the general population, for pregnant women, or for adults over age 65.
- In the VSD, studies have found no association between Tdap vaccination and Guillain-Barre Syndrome or other neurologic disorders. Other studies have found that there is no increased risk for other types of health problems, such as allergies, blood disorders, and chronic illnesses.
- Although injection site reactions are common, studies have found a low rate of severe reactions. These local reactions are unusual even when the vaccine is given at the same time as meningococcal conjugate vaccine (Menactra), or when a person receives several doses of Tdap vaccine over a short time period.
- Diphtheria, Tetanus, and Pertussis (DTaP) Vaccine Information Statement
- DTaP Vaccine: Who Should Not Get Vaccinated
- Tdap (Tetanus, Diphtheria, Pertussis) Vaccine Information Statement
- Tdap Vaccine: Who Should Not Get Vaccinated
- Tetanus (Lockjaw) Vaccination
- Diphtheria Vaccination
- Pertussis (Whooping Cough) Vaccination
- U.S. Vaccine Abbreviations Cdc-pdf[PDF – 196 KB]
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