Hepatitis A Vaccines

Safety Information

Hepatitis A Disease and How to Protect Against It

The Hepatitis A virus causes liver disease that can last from a few weeks to several months.  People become infected by close personal contact with someone who is infected or by drinking or eating contaminated food or drinks.  You can protect against Hepatitis A with safe, effective vaccination.

Hepatitis A Vaccine Side Effects

The Hepatitis A vaccine is very safe, and it is effective at preventing the Hepatitis A disease. Vaccines, like any medicine, can have side effects. About half of the people who get the Hepatitis A vaccine have no side effects at all. In the other half of people, most report having very mild side effects, like a sore arm from the shot for a day or two. The most common side effects are usually mild and last 1 or 2 days.

Common Side Effects of Hepatitis A Vaccine:
  • Sore arm from the shot
  • Headache
  • Tiredness
  • Fever
  • Loss of appetite

Available Hepatitis A Vaccines

There are three Hepatitis A vaccines approved for use in the United States:

How CDC Monitors the Hepatitis A Vaccine Safety

CDC and FDA continuously monitor the safety of vaccines after they are approved.  If a problem is found with a vaccine, CDC and FDA will inform health officials, health care providers, and the public.

CDC uses three systems to monitor vaccine safety:

A Closer Look at the Safety Data

  • A 2-year reviewexternal icon of Hepatitis A vaccine safety using VAERS data, found no safety problems when the vaccine began to be used as part of the routine immunization schedule in the United States
  • A 2004 studyexternal icon of Vaqta among a large group of California patients showed no health problems linked to vaccination. More than 49,000 doses of Hepatitis A vaccine were given to the patients; 15,000 were given to children younger than 18 years of age.

Related Scientific Articles

Black S, Shinefield H, Hansen J, Lewis E, Su L, Coplan P. A post-licensure evaluation of the safety of inactivated hepatitis A vaccine (VAQTA, Merck) in children and adultsexternal icon. Vaccine. 2004 Jan 26;22(5-6):766-72.

Karali Z, Basaranoglu ST, Karali Y, Oral B, Kilic SS.  Autoimmunity and hepatitis A vaccine in childrenexternal icon. J Investig Allergol Clin Immuno. 2011;21(5):389-93.

Niu MT, Salive M, Kruger C, Ellenberg SS. Two-year review of hepatitis A vaccine safety:  Data from the Vaccine Adverse Event Reporting System (VAERS)external iconClin Infect Dis. 1998 Jun;26(6):1475-6.

Woo EJ, Miller NB, Ball R, VAERS Working Group. Adverse events after hepatitis A B combination vaccineexternal icon. Vaccine. 2006 Mar 24;24(14):2685-91.