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Understanding the Impact of Zika during Pregnancy Globally to Protect Mothers and Babies

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To protect mothers and babies, CDC is collecting information to understand the impact of Zika virus during pregnancy and the long-term health outcomes of congenital Zika virus infection globally.

Understanding the Impact of Zika during Pregnancy Globally to Protect Mothers and Babies

The devastating scale of the Zika virus outbreaks in Colombia and Brazil drove the CDC to work with health departments in both countries to track and care for groups mothers and babies in both countries to better understand the long-term outcomes of Zika virus infection during pregnancy. This work, supported in part by the United States Agency for International Development (USAID), will provide a common defense for the country against the unprecedented challenges posed by Zika virus infection during pregnancy.

Proyecto Vigilancia de Embarazadas con Zika

CDC, in partnership with the Instituto Nacional de Salud (INS) and Ministry of Health in Colombia, is working on the Proyecto Vigilancia de Embarazadas con Zika (VEZ). Proyecto VEZ is a system that tracks the health of pregnant women with Zika virus infection and their infants in areas in Colombia with the highest number of women with Zika virus infection during pregnancy. Through this collaboration, CDC and INS hope to better understand

  • The full range of potential health problems that congenital Zika virus infection might cause
  • The risk of poor outcomes among fetuses and infants of women infected with Zika during pregnancy
  • When during pregnancy Zika virus infection poses the highest risk to the fetus

Zika en Embarazadas y Niños

Zika en Embarazadas y Niños (ZEN) is a research study that includes pregnant women in their first trimester, their male partners, and their babies. Infants born to mothers enrolled in the study during pregnancy will be followed up to six months of age. A subset of children, along with a parent or legal guardian, will be followed until the child is about four years of age. The ZEN study aims to

  • Advance the understanding of short- and long-term health and developmental consequences of Zika virus infection during pregnancy and the health of affected children
    • Identify and describe how parents are affected by health issues of their children
  • Inform and improve clinical care and guidelines related to the long-term care of children who were affected by Zika virus infection
  • Provide critical information leading to evidence-based strategies to prevent Zika virus infection in pregnancy
  • Improve counseling of patients about risks to themselves, their pregnancies, and their children
  • Increase the preparedness of agencies providing services to affected children and families

Case Investigation

INS has a robust national public health tracking system for notifiable conditions, including birth defects, and has monitored the Zika virus outbreak closely since it began. CDC has provided technical assistance to INS in the investigation of all infants born with microcephaly or other central nervous system defects to determine whether they are Zika-related.

For more information, see Preliminary Report of Microcephaly Potentially Associated with Zika Virus Infection During Pregnancy — Colombia, January–November 2016.

Zika Outcomes and Development in Infants and Children (ZODIAC)

CDC is collaborating with Brazil’s Ministry of Health to conduct a follow-up assessment of babies aged 12-24 months with congenital Zika virus infection in Brazil. The ZODIAC project seeks to better understand the longer-term impacts of Zika virus infection on children infected before birth and their families. The project focuses on physical growth, birth defects, vision, hearing, and the development of cognitive, social, language, and motor skills. ZODIAC also looks at how family functioning has been affected by the baby’s Zika virus infection, and the care needs of the children and families. Data collection began in August 2017.

Read the first report from the ZODIAC study »

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