Available Technologies for Licensing and Collaboration

CDC PHIL photo, Todd Jordan.

Diagnostics

Antibiotic/Antimicrobial Resistance

• DNA Probes to Rapidly Screen Candida glabrata Isolates for Echinocandin Resistance to Antifungal Treatment
• Real-Time PCR Assay for Detection of Carbapenem Antibiotic Resistance Genes of the IMP-type

Fungal/Fungi Detection

• Detection and Differentiation of Pathogenic Fungi in Clinical Samples Using a Multi-Analyte Profiling System
• Nucleic Acid Assays for the Detection and Discrimination of Aspergillus Fungi Species within Biological Samples
• Nucleic Acid-based Compositions and Methods for the Detection of Pathogenic Candida or Aspergillus Fungi Species
• Nucleic Acid-based Compositions and Methods for the Species-Specific Detection of Pathogenic Candida Fungi
• Nucleic Acid Detection of the Fungal Pathogen Histoplasma capsulatum from Clinical and Environmental Samples
• Nucleic Acid-based Differentiation and Identification of Medically Important Fungi
• Species-specific Nucleic Acid Detection Assay for Fungi

Gastrointestinal/Enteric

• Controlled Expression and Assembly of Human Group-C Rotavirus-like Particles for Creation of Rotavirus Diagnostic Assays and Improved Vaccine Formulations
• Diagnostic Assays Utilizing Real-Time Taqman or Seminested RT-PCR for Parechovirus Detection and Discrimination
• Diagnostic Assay to Detect Group C Rotavirus in Humans and Animals—Monoclonal Antibody-based ELISA (Enzyme-linked Immunosorbent Assay)
• Multiplex Assay for Rapid Salmonella Serotyping from Human, Animal, Food and Environmental Sources
• Multiplex Real-time PCR Assay for Detection of Numerous Bacterial Pathogens Important in Neonatal Infection and Food Safety
• Novel Human Rotavirus Vaccine CDC-6 Strain for Impacted Subgroup, the Lewis Negative Population
• One-step random amplification method to detect extremely low input nucleic acids for virome, microbiome, and metagenomics in clinical and biological specimens — Thus far, CDC has achieved whole genome sequencing of a variety of viruses directly from clinical specimens, including but not limited to enterovirus (EV-D68, CV-A24, and EV-A71), cosavirus, parechovirus, and norovirus
• Recombinant Polypeptides for Clinical Detection of Taenia solium and Diagnosis of Cysticercosis
• Real-Time RT-PCR Assay for Detection of Noroviruses
• Real-time RT-PCR Assay for Rapid, Highly Sensitive and Specific Detection of Human Enterovirus D68 (EV-D68)
• Sensitive Method for Detection and Quantification of Anthrax, Bordetella pertussis, Clostridium difficile, Clostridium botulinum and Other Pathogen-Derived Toxins in Human and Animal Plasma

Hepatitis

• Immunogenic Hepatitis E Virus Polypeptides for Vaccine and Diagnostics Development
• Novel Enzyme-Based Immunoassay for Simultaneous Detection of Hepatitis C Virus Antigen and Antibody in Human Serum or Plasma
• Real-time RT-PCR Assay For Detection and Quantification of Hepatitis D Virus Infection

Rabies and Lyssaviruses

• Antigen-capture Electrochemiluminescent Assay for Determining Rabies Vaccine Potency
• High-throughput assay for detection of rabies neutralizing antibodies
• Isolated Lyssavirus Nucleic Acid and Protein Sequences
• Monoclonal Antibodies for Detection of Rabies Virus Antigen and Confirmatory Rabies Diagnosis
• Real-Time RT-PCR Assay for the Rapid Detection of Rabies and Other Lyssaviruses

Respiratory

Respiratory – Anthrax

• Assay for Early Diagnosis of Anthrax Using Monoclonal Antibodies Against Anthrax Toxin
• Exposure and Activity Detection Assays for Anthrax Lethal Factor and Lethal Toxin
• Novel Epitopes of Bacillus anthracis Lethal Factor for Development of Diagnostics and Therapeutics
• Stable, Early-stage Biomarker for Diagnosis of Bacillus anthracis Infection and Anthrax Vaccine Development
• Sensitive Method for Detection and Quantification of Anthrax, Bordetella pertussis, Clostridium difficile, Clostridium botulinum and Other Pathogen-Derived Toxins in Human and Animal Plasma

Respiratory – Enterovirus

• Enterovirus Molecular Diagnostic Test Kit

Respiratory – Fungal/Fungi including Candida

• Nucleic Acid-based Compositions and Methods for the Detection of Pathogenic Candida or Aspergillus Fungi Species
• Nucleic Acid-based Compositions and Methods for the Species-Specific Detection of Pathogenic Candida Fungi
• Nucleic Acid Detection of the Fungal Pathogen Histoplasma capsulatum from Clinical and Environmental Samples

Respiratory – Influenza

• Human Influenza Virus Real-time RT-PCR: Detection and Discrimination of Influenza A (H3N2) Variant from Seasonal…
• Immunoassay for the Simultaneous Detection of Functional Antibodies against Multiple Serotypes of Streptococcus…
• Influenza A Virus Detection and Subtyping Directly from Animal Swabs and Environmental Samples
• MDCK-based Reporter System for Detection of Influenza Viruses, Antiviral Drug Screening, and Analysis of Neutralizing Antibodies
• Methods of Detecting and Identifying Both Known and Novel Influenza Viruses
• New Anti-Influenza Virus Neuraminidase 9 (N9) Monoclonal Antibody – for Prevention or Treatment of H7N9 Influenza (Flu) A with Less Likelihood of Drug Resistance
• Real-time RT-PCR Assay for Detection of Live Attenuated Influenza Vaccine for A and B Viruses
• Real-Time RT-PCR Assay for Influenza B Lineage Characterization
• Real-Time PCR Assay for Specific Detection of Haemophilus influenza Serotypes A and B
• Real-time RT-PCR Detection and Characterization Panel for Human Influenza Virus
• Real-time RT-PCR: Detection and Discrimination of Human Influenza A (H3N2) Variant from Seasonal Influenza A (H3N2) Viruses, Including H3v and Seasonal H3 Assays
• The CDC 2009 Influenza A H1N1 (Flu) Pandemic Real-time RT-PCR Panel including Pandemic Influenza A and Pandemic H1 Assays

Respiratory – Legionella

• Simultaneous Detection of non-pneumophila Legionella Strains Using Real-Time PCR

Respiratory – Pertussis

• Real-time PCR Assays for Selective Detection and Differentiation of B. pertussis, B. parapertussis and B. homesii
• Sensitive Method for Detection and Quantification of Anthrax, Bordetella pertussis, Clostridium difficile, Clostridium botulinum and Other Pathogen-Derived Toxins in Human and Animal Plasma

Respiratory – Pneumonia

• Antigen, Encoding Gene, Related Monoclonal Antibody and Hybridoma Clones for Streptococcus pneumoniae Serological Diagnostics
• Encapsulated Streptococcus Compositions and Methods for Pneumococcal Vaccine, Probiotic, and Diagnostic Assay Development
• Immunoassay for the Simultaneous Detection of Functional Antibodies against Multiple Serotypes of Streptococcus pneumonia and Other Bacteria Types
• Multi-Antigenic Peptide(s) Vaccine and Immunogen for Conferring Streptococcus pneumonia Immunity
• Novel Peptide of Streptococcus pneumonia Surface Adhesion A (PsaA) Protein Associated with Adherence and Uses Thereof – for Vaccine Candidate, Therapeutic and Diagnostic Development
• Peptide Sequences for Chlamydophila pneumonia Vaccine and Serological Diagnosis
• Peptide Vaccines Against Group A Streptococci
• Real-time PCR and High Resolution Melt Analysis for Genotyping of Pneumonia Type – Chlamydophila psittaci
• Real-time PCR Detection of Streptococcus pneumonia with High Sensitivity and Specificity
• Real-time PCR Assay for Detection of Pneumococcal DNA and Diagnosis of Pneumococcal Disease
• Simple and Rapid Loop-Mediated Isothermal Amplification (LAMP)-based Assay for Mycoplasma pneumoniae Detection

Respiratory – Tuberculosis

• Diagnostic Antigens for the Identification of Latent Tuberculosis Infection
• Nucleic Acid Amplification Technique for Rapid Diagnostic Analysis for Tuberculosis, Malaria and Other Infectious Diseases
• Rapid Detection of Multi-Drug-Resistant Mycobacterium tuberculosis Using Real-Time PCR and High-Resolution Melt Analysis

Respiratory – Other

• Detection of Stachybotrys chartarum (a Type of Fungus/Black Mold) with Monoclonal Antibodies
• Diagnostic Assays Utilizing Real-Time Taqman or Seminested RT-PCR for Parechovirus Detection and Discrimination
• Hybridomas to Human Immunoglobulins for SARS-CoV-2 Diagnostics and Additional Indications
• Methods for the Simultaneous Detection of Multiple Analytes
• Multiplex Real-time PCR Assay for Detection of Numerous Bacterial Pathogens
• Personal Air Sampler for Collecting Airborne Aerosol Particulates for Molecular Analysis by Size
• Real-time PCR Assays for Human Bocavirus Detection and Diagnosis
• Real-time PCR Assays for Selective Detection and Differentiation of B. pertussis, B. parapertussis and B. homesii
• Real-Time PCR Multiplex Assay for Detection of Bacterial Respiratory Pathogens in Clinical Specimens
• Real-time TaqMan RT-PCR Assays for Selective Detection of Human Rhinovirus
• Sensitive Method for Detection and Quantification of Anthrax, Bordetella pertussis, Clostridium difficile, Clostridium botulinum and Other Pathogen-Derived Toxins in Human and Animal Plasma

Sexually Transmitted Diseases (STDs)

HIV (Subtypes 1 & 2) and Simian HIV

• Composition and Methods for Rapid Detection of HIV by Loop-mediated Isothermal Amplification
• Detection of Retroviruses and HIV-1 Groups -M and -O Discrimination within Clinical Serum Samples
• HIV-1 BED: A Simple Serological Assay for Detecting Recent Infection and Estimating Incidence of Multiple, Worldwide HIV-1 Subtypes
• Improved Simian HIV (SHIV) Prevention in Non-human Primate Models with Chemoprophylaxis Combination that Can Be Taken in One or Two Oral Doses Before or After Exposure
• Molecular Detection and Viral-Load Quantification for HIV-1 Groups M, N and O, and Simian Immunodeficiency Virus-cpz (SIVcpz)
• Monoclonal Antibodies to the HIV-1 Core Protein p24
• Monoclonal Antibody to Detect the Antiretroviral Drug Emtricitabine – for HIV Drug Adherence Monitoring
• Multiple Antigenic Peptide Assay for Detection of HIV or SIV Type Retroviruses
• Multivalent Multiple-Antigenic-Peptides (MAPs) for the Detection of Antibodies to HIV-1 Group M, N, and O, and HIV-2
• Novel One-Well Limiting-Antigen Avidity Enzyme Immunoassay to Detect Recent HIV-1 Infection Using a Multi-subtype Recombinant Protein – please contact TTO at TTO@cdc.gov
• On-site in vitro Diagnostic: Real-time Loop-Mediated Isothermal Amplification Detection of HIV-2 Groups A and B
• Rapid Detection of Antiretroviral(s) Drug-Resistant HIV-1 within Clinical Samples
• Real-Time PCR Assay for HIV-1 Subtype Diagnosis and Global Surveillance of Drug Resistance
• Simian T-Cell Lymphotropic Virus Strain Type 3 (STLV-3) Subtype D Variant, a Highly Divergent STLV-3, for Development of Diagnostics, Therapeutics, Vaccines and Research Tools
• Simple and Rapid Assay to Detect Acute Subtype B and Group M HIV-1 Infections
• Simple, Rapid, and Sensitive Real-Time PCR Assays for Detecting Drug Resistance in Human Immunodeficiency Viruses (HIV)

Syphilis

• Cardiolipin Modification for Immunoassay Detection of Syphilis
• Diagnostic Assay with Modified Cardiolipin for Detecting Active Syphilis Infections
• Immunoassays and Methods to Diagnose Syphilis by Immobilizing a Lipoidal Antigen on a Solid Support
• Methods for Detecting Syphilis Using Synthetic Antigens

Tropical/Emerging Diseases (Includes Flaviruses)/Zoonotic

• Chimeric Dengue/Zika Viruses for Live-Attenuated Zika Vaccine (and Diagnostic) Development
• Chimeric Reporter West Nile/Dengue Viruses and Their Use for Assay Development
• CDC Trioplex Real-Time RT-PCR Assay for Detection and Differentiation of Zika, Dengue, & Chikungunya Virus
• Discrete Cross-Reactive Epitopes for Flavivirus Serological Diagnostics and Vaccines
• Heartland Virus Humanized Monoclonal Antibodies for Diagnostic and Therapeutic Development
• High-Titer, Fast-Growth Chimeric Dengue/West Nile Viruses for Vaccine and Diagnostics Development
• Monoclonal Antibodies Against Coxiella burnetii, the Cause of Q Fever for Diagnostic Development
• Monoclonal Antibodies for Specific Detection of Dengue Virus Sub-type 4 in Human Serum
• Monoclonal Antibodies that Bind Zika Virus Envelope Protein for Zika Diagnostics and Research
• Monoclonal Antibody that Detects a Subclass of Dog IgG—for Diagnostic and Research Applications
• Multiplex Assay for Detection of Dengue Virus
• Novel Fourth Human Ebolavirus species, Bundibugyo ebolavirus – Compositions and Methods for Vaccine, Therapeutics and Highly Sensitive Diagnostic Assay Development
• Novel Inactivated Zika Vaccine Candidate Based on Purified Wild-type Zika Virus — for Zika Vaccine and Diagnostic Assay Development
• Novel Method and Kit Using Monoclonal Antibodies for More Sensitive Detection of Dengue Virus
• Nucleic Acid Amplification Technique for Rapid Diagnostic Analysis for Malaria, Tuberculosis and Other Infectious Diseases
• Nucleic Acid Primers and Probes for Detecting Ebola Virus (species Zaire ebolavirus)
• Rapid Colorimetric Detection of Zika Virus from Serum and Urine Specimens by RT-LAMP (Reverse Transcription Loop-Mediated Isothermal Amplification)
• Real-Time RT-PCR Detection of Rickettsia species — PanR6/Total Nucleic Acid Assay with High Sensitivity and Specificity
• Real-Time RT-PCR Detection of Scrub Typhus Total Nucleic Acid Assay with High Sensitivity and Specificity
• Recombinant Nucleic-Acid Based Flavivirus Nucleic Acids for Development of Vaccines and/or Sero-diagnostics
• Simple, Field-Usable Fluorescence-Based Isothermal LAMP Assay for the On-Site Diagnosis of Malaria
• Stable Human Cell Lines Expressing Flavivirus Virus-Like Particles (VLPs) for Vaccine, Biologics, and Diagnostic Development
• Use of Vitronectin as a Biomarker for the Detection of a Dengue Hemorrhagic Fever
• West Nile/Zika Virus Chimeras for Inactivated Zika Vaccine and Diagnostic Assay Development
• Zika Virus NS1 Protein Monoclonal Antibodies for Research, Development, and Novel Diagnostics
• Zika Virus VLP (Virus-like Particle) Antigens for Vaccine Candidate and Diagnostic Development

Other

• Compositions and Methods for Improved Lyme Disease Diagnosis
• Diagnostics, Vaccines, and Delivery-Vehicles Related to Novel Phlebovirus
• Encapsulated Streptococcus Compositions and Methods for Pneumococcal Vaccine, Probiotic, and Diagnostic Assay Development – potential commercial application for other pneumococcal conditions (e.g., ear infections, meningitis, and bacteremia)
• Generation of Artificial Mutation Controls for Diagnostic Testing
• Human Retrovirus (Spumavirus) Obtained from Infected Chimpanzee Exposure
• Hybridomas to Human Immunoglobulins for SARS-CoV-2 Diagnostics and Additional Indications
• Improved Botulism, Botulinum Neurotoxin Type-E Diagnostics
• Method to Remove Human DNA When Sequencing for Parasite Infection
• Method to Remove Mycoplasma Contamination from Virus Stocks
• Microbial Testing – Photo-induced Electron Transfer Fluorescent Primer for Nucleic Acid Amplification
• Monitoring Public Water Supply for a Variety of Pathogens
• Monoclonal Antibody that Detects a Subclass of Dog IgG—for Diagnostic and Research Applications
• Multiplexed Immunoassay for Rapid Serological Diagnosis of a Specific Viral Infection in Clinical Samples
• Multiplex Real-time PCR Assay for Detection of Numerous Bacterial Pathogens Important in Neonatal Infection and Food Safety
• Newborn Screening – Multiplexing Homocysteine in Primary Newborn Screening Assays Using Maleimides as Select Derivatization Agents
• Novel Primate T-cell Lymphotropic Viruses (HTLV, STLV) for Development of Diagnostics, Therapeutics, and Research Tools
• Novel UNEX Buffer and Disk for Safe Storage and Transport at Ambient Temperatures of Clinical Specimens for Molecular Testing of Pathogens
• Nucleic Acid Amplification Technique for Rapid Diagnostic Analysis for Tuberculosis, Malaria and Other Infectious Diseases
• Portable Laser-Operated Counterfeit Drug Identifier (CoDI) for Tablets
• Rapid Method for the Detection of Antigen-Specific Antibodies in Any Species
• Real-time RT-PCR Assay for the Detection of Rift Valley Fever Virus in Humans and Livestock
• Sensitive Method for Detection and Quantification of Anthrax, Bordetella pertussis, Clostridium difficile, Clostridium botulinum and Other Pathogen-Derived Toxins in Human and Animal Plasma
• Simian T-Cell Lymphotropic Virus Strain Type 3 (STLV-3) Subtype D Variant, a Highly Divergent STLV-3, for Development of Diagnostics, Therapeutics, Vaccines and Research Tools
• SodC-Based Real-Time PCR Assay for Detection of Neisseria meningitis Infection
• Universal Diagnostic Assay for Detection and Identification of Poxviruses in Clinical Samples
• Veterinary – Monoclonal Antibody that Detects a Subclass of Dog IgG—for Diagnostic and Research Applications

Aerosol Exposure

• Computer Controlled Aerosol Generator with Multi-Walled Carbon Nanotube Inhalation Testing Capabilities 
• Non-radioactive, Miniature Bipolar Aerosol Particle Charger for Personal, Portable Instrumentation 

Air Quality and Aerosol Analysis

• Air Quality Assurance: A Monitor for Continuous, Simultaneous Analysis of Atmospheric or Aerosolized Particulate Mixtures
• Focused Electrostatic Collection of Aerosol Particles for Chemical Analysis by Spectroscopic Techniques
• Inexpensive, Personal Dust Detector Tube/Dosimeter Operating on a Gas Detector Tube Platform
• Methods for Near Real-time Chemical Analysis of Aerosols using Microwave-induced Plasma Spectroscopy
• Mobile Instrumentation for the Detection and Sampling of Aerosol Particles
• Near Real-time, Low-cost, Hand-held Sensors for Measuring Elemental Concentration of Airborne Particles for Indoor or Outdoor Air Quality Monitoring
• Personal Air Sampler for Collecting Airborne Aerosol Particulates for Molecular Analysis by Size
• Physiologic Sampling Pump Capable of Rapidly Adapting to User Breathing Rate
• Silica Exposure Safety: Mini-baghouse Systems and Methods for Controlling Particulate Release from Large Sand Transfer Equipment

Environmental, Public Health or Veterinary/Zoonotic

• Bacterial Pathogen Testing (for Humans & Animals) – Sensitive Method for Detection and Quantification of Anthrax, Bordetella pertussis, Clostridium difficile, Clostridium botulinum and Other Pathogen-Derived Toxins in Human and Animal Plasma

• Bacterial Pathogen Testing (for Neonatal Infection & Food Safety) – Multiplex Real-time PCR Assay for Detection of Numerous Bacterial Pathogens Important in Neonatal Infection and Food Safety
• Bat Restraint for Blood Sample Collection

• Botulinum Diagnostics – Improved Botulism, Botulinum Neurotoxin Type-E Diagnostics
• Counterfeit Drug Detection – A Simple Colorimetric Assay for Anti-malarial Drugs Quality Assurance and Rapid, On-site Counterfeit Detection
• Influenza A Virus Detection – Influenza A Virus Detection and Subtyping Directly from Animal Swabs and Environmental Samples

Disease/Infection Detection 

• Biomarker Discovery – Use of Detector Response Curves to Optimize Settings for Mass Spectrometry
• Chronic and Infectious Disease Detection – Methods of Retaining Methylation Pattern Information in Globally Amplified DNA
• Disease Screening/Diagnostic Testing (for Humans & Other Animals, particularly Birds) – Real-time PCR and High Resolution Melt Analysis for Genotyping of Chlamydophila psittaci
• Environmental Safety – Diisocyanate Specific Monoclonal Antibodies for Occupational and Environmental Monitoring of Polyurethane Production Exposure-related Asthma and Allergy and Clinical Diagnosis
• Influenza A Virus Detection – Influenza A Virus Detection and Subtyping Directly from Animal Swabs and Environmental Samples
• S. Pneumoniae and Other Infectious Disease Detection  – Methods for the Simultaneous Detection of Multiple Analytes

Fungal Detection

• Detection and Differentiation of Pathogenic Fungi in Clinical Samples Using a Multi-Analyte Profiling System
• Monoclonal Antibodies for Detection of Stachybotrys chartarum (a Fungus)
• Nucleic Acid Detection of the Fungal Pathogen Histoplasma capsulatum from Clinical and Environmental Samples
• Nucleic Acid-based Differentiation and Identification of Medically Important Fungi
• Nucleic Acid Assays for the Detection and Discrimination of Aspergillus Fungi Species within Biological Samples
• Nucleic Acid-based Compositions and Methods for the Detection of Pathogenic Candida or Aspergillus Fungi Species
• Nucleic Acid-based Compositions and Methods for the Species-Specific Detection of Pathogenic Candida Fungi
• Species-specific Nucleic Acid Detection Assay for Fungi

Lead Detection &/or Removal

• Handwipe Disclosing Method for Detecting the Presence of Lead
• Wipes and Methods for Removal of Lead and Other Metal Contamination from Surfaces

Lyme Disease Diagnostics

• Compositions and Methods for Improved Lyme Disease Diagnosis

Microbial Testing for Water & Public Health

• Fluorescent Primer(s) Creation for Nucleic Acid Detection and Amplification
• Monitoring Public Water Supply for a Variety of Pathogens
• Nucleic Acid Amplification Technique for Rapid Diagnostic Analysis/GEAR
• Photoinduced Electron Transfer Fluorescent Primer for Nucleic Acid Amplification
• Pathogen Detection/Diagnostic for Veterinary – Rapid Method for the Detection of Antigen-Specific Antibodies in Any Species
• Rift Valley Fever Detection – Real-time RT-PCR Assay for the Detection of Rift Valley Fever Virus in Humans and Livestock
• Salmonella Diagnostics/Food Safety – Multiplex Assay for Rapid Salmonella Serotyping from Human, Animal, Food and Environmental Sources
• Viral Infection Diagnostics – Multiplexed Immunoassay for Rapid Serological Diagnosis of a Specific Viral Infection in Clinical Samples
• Virus Testing Assay for Vaccine Development – Virus Microneutralization Assay Data Analysis for Vaccine Development, Enhancement and Efficacy Improvement

Hazard Assessment

• Local Positioning System for Position-Time-Condition Correlation, Data-logging and Analysis

Hearing Safety

• System for Monitoring Exposure to Impulse Noise

Mosquito Control including Netting, Repellent, and Traps

• A Bias-free Sampling and Collection Trap for Resting Mosquitoes
• CDC Mosquito Trap for Control and Surveillance of Mosquitoes Including Carriers of Zika & Other Viruses
• Entangling/Entrapping Synthetic Setae for Control of Insects and Other Pests
• Field-Adapted Spot Test for Evaluating Materials Treated with Permethrin Insect Repellent

Musculoskeletal Injury Prevention

• Portable Exposure Assessment System for Prevention of Musculoskeletal Injury

Pulmonary Assessment and Respirator Technology

• Improved Acoustic Plethysmograph System for Noninvasive Measurement of Pulmonary Function
• Mining Safety: Personal Dust Monitor Filters for Accurate, Quantifiable Spectrometric Analysis and Assessment of Worker Exposure Levels
• Respirator Protection Devices and Methods to Detect and Remove Toxic Gases from the Air – Cobinamide Encapsulated Silica-based Materials for Respirator Canisters
• Ultrasonic in Situ Respirator Seal-leakage Detection with Real-time Feedback Capabilities

Water Monitoring

• Fluorescent Primer(s) Creation for Nucleic Acid Detection and Amplification
• Monitoring Public Water Supply for a Variety of Pathogens
• Nucleic Acid Amplification Technique for Rapid Diagnostic Analysis/GEAR
• Photo-induced Electron Transfer Fluorescent Primer for Nucleic Acid Amplification

Occupational Safety and Health Technologies

Aerosol Exposure

• Computer Controlled Aerosol Generator with Multi-Walled Carbon Nanotube Inhalation Testing Capabilities
• Non-radioactive, Miniature Bipolar Aerosol Particle Charger for Personal, Portable Instrumentation

Air Quality and Aerosol Analysis

Workers in construction, sandblasting, and mining face significant health risk from the inhalation of silica dust. CDC NIOSH Researchers developed the mini-baghouse retrofit assembly to control the amount of respirable crystalline silica dust released from sand moving machinery by trapping the hazardous particles and reducing air pollution. This retrofit device is an easy to assemble, cost effective solution for existing oil and gas machinery.

CDC NIOSH photo, Michael Breitenstein.

• Air Quality Assurance: A Monitor for Continuous, Simultaneous Analysis of Atmospheric or Aerosolized Particulate Mixtures
• Focused Electrostatic Collection of Aerosol Particles for Chemical Analysis by Spectroscopic Techniques
• Inexpensive, Personal Dust Detector Tube/Dosimeter Operating on a Gas Detector Tube Platform
• Methods for Near Real-time Chemical Analysis of Aerosols using Microwave-induced Plasma Spectroscopy
• Mobile Instrumentation for the Detection and Sampling of Aerosol Particles
• Near Real-time, Low-cost, Hand-held Sensors for Measuring Elemental Concentration of Airborne Particles for Indoor or Outdoor Air Quality Monitoring
• Personal Air Sampler for Collecting Airborne Aerosol Particulates for Molecular Analysis by Size
• Physiologic Sampling Pump Capable of Rapidly Adapting to User Breathing Rate
• Silica Exposure Safety: Mini-baghouse Systems and Methods for Controlling Particulate Release from Large Sand Transfer Equipment

Asthma and Allergies

• Diisocyanate Specific Monoclonal Antibodies for Occupational and Environmental Monitoring of Polyurethane Production Exposure-related Asthma and Allergy and Clinical Diagnosis

Ergonomic and Musculoskeletal Injury Prevention

• Cylindrical Handle Dynamometer for Improved Grip-Strength Measurement
• Portable Exposure Assessment System for Prevention of Musculoskeletal Injury
• Wearable Kneel-Sit Support Device for Manual Labor and Heavy Industry Applications

Fall Prevention

• Adjustable Barricade Safety Rail System and Roof Bracket Assembly to Prevent Worker Falls
• Extension-Ladder Safety: Multimodal-feedback Indicator for Improved Ladder Positioning Safety and Efficiency

Fishing and Maritime Safety

• Cable-line Safety System: Electro/hydraulic Emergency Stop Device for a Winch, Drum or Capstan
• Emergency Maritime Battery Charger
• Swing-Away Winch Cathead Guard

Hazard Assessment

• Local Positioning System for Position-Time-Condition Correlation, Data-logging and Analysis
• Warning System for Mobile Machinery Hazardous Zones

Head Injury Prevention

• Air-bubble Cushioning Application to Improve Shock Absorption Performance of Construction and Industrial Helmets

Hearing Safety

• System for Monitoring Exposure to Impulse Noise

Lead Detection and Removal

• Handwipe Disclosing Method for Detecting the Presence of Lead
• Wipes and Methods for Removal of Lead and Other Metal Contamination from Surfaces

Mining Safety

• Personal Dust Monitor Filters for Accurate, Quantifiable Spectrometric Analysis and Assessment of Worker Exposure Levels

Mold/Fungus Detection

• Monoclonal Antibodies for Detection of Stachybotrys chartarum (a Fungus)
• Nucleic Acid Detection of the Fungal Pathogen Histoplasma capsulatum from Clinical and Environmental Samples

Patient Isolation

• Mobile Patient Isolation Headboard and Canopy System – *please contact TTO@cdc.gov for more information.
• Ventilated Patient Headboard and Canopy System – *please contact TTO@cdc.gov for more information.

Pulmonary Assessment and Respirator Technology

• Device to Measure Muscle Contractile-Relaxant and Epithelial Bioelectric Responses of Perfused, Intact, Tracheal Airways Tissue In Vitro
• Improved Acoustic Plethysmograph System for Noninvasive Measurement of Pulmonary Function
• Methods and Apparatus for Computer-Aided Cough Sound Analysis
• Respirator Protection Devices and Methods to Detect and Remove Toxic Gases from the Air – Cobinamide Encapsulated Silica-based Materials for Respirator Canisters
• Ultrasonic in situ Respirator Seal-Leakage Detection with Real-time Feedback Capabilities

Telemedicine

• Ausculatatory Training System and Telemedicine Tool with Accurate Reproduction of Physiological Sounds

Aerosol Exposure

• Computer Controlled Aerosol Generator with Multi-Walled Carbon Nanotube Inhalation Testing Capabilities
• Non-radioactive, Miniature Bipolar Aerosol Particle Charger for Personal, Portable Instrumentation

Air Quality and Aerosol Analysis

• Air Quality Assurance: A Monitor for Continuous, Simultaneous Analysis of Atmospheric or Aerosolized Particulate…
• Focused Electrostatic Collection of Aerosol Particles for Chemical Analysis by Spectroscopic Techniques
• Inexpensive, Personal Dust Detector Tube/Dosimeter Operating on a Gas Detector Tube Platform
• Methods for Near Real-time Chemical Analysis of Aerosols using Microwave-induced Plasma Spectroscopy
• Mobile Instrumentation for the Detection and Sampling of Aerosol Particles
• Personal Air Sampler for Collecting Airborne Aerosol Particulates for Molecular Analysis by Size
• Physiologic Sampling Pump Capable of Rapidly Adapting to User Breathing Rate
• Silica Exposure Safety: Mini-baghouse Systems and Methods for Controlling Particulate Release from Large Sand…

Bat Restraint

• Bat Restraint for Blood Sample Collection

Counterfeit Drug Detection

• A Simple Colorimetric Assay for Anti-malarial Drugs Quality Assurance and Rapid, On-site Counterfeit Detection
• Portable Laser-Operated Counterfeit Drug Identifier (CoDI) for Tablets

Diagnostics

• HIV-1 – A Device for Simultaneous and Rapid Diagnosis and Detection of Recent and Long Term HIV-1 Infection
• Botulism – Improved Botulism, Botulinum Neurotoxin Type-E Diagnostics
• Clostridium difficile (C. difficile), Bordetella pertussis, and more — Sensitive Method for Detection and Quantification of Anthrax, Bordetella pertussis, Clostridium difficile,…
• Dengue – Novel Method and Kit Using Monoclonal Antibodies for More Sensitive Detection of Dengue Virus
• Mass Spectrometry and Biomarker Analysis – Use of Detector Response Curves to Optimize Settings for Mass Spectrometry
• Rickettsia – Real-Time RT-PCR Detection of Rickettsia species — PanR6/Total Nucleic Acid Assay with High Sensitivity and Specificity
• Scrub Typhus – Real-Time RT-PCR Detection of Scrub Typhus Total Nucleic Acid Assay with High Sensitivity and Specificity
• Syphilis – Immunoassays and Methods to Diagnose Syphilis by Immobilizing a Lipoidal Antigen on a Solid Support

• Water Pathogens — Monitoring Public Water Supply for a Variety of Pathogens

Drug Delivery

• Intranasal Dry Powder Inhaler for Improved Delivery of Vaccines and Therapeutics
• Intranasal Nebulizer with Disposable Drug Cartridge for Improved Delivery of Vaccines and Therapeutics

Ergonomic and Musculoskeletal Injury Prevention

• Cylindrical Handle Dynamometer for Improved Grip-Strength Measurement

• Occupational Health: Wearable Kneel-Sit Support Device for Manual Labor and Heavy Industry Applications
• Occupational Safety: Portable Exposure Assessment System for Prevention of Musculoskeletal Injury

Fall Prevention

• Extension-Ladder Safety: Multimodal-feedback Indicator for Improved Ladder Positioning Safety and Efficiency

Fishing and Maritime Safety

• Cable-line Safety System: Electro/hydraulic Emergency Stop Device for a Winch, Drum or Capstan
• Emergency Maritime Battery Charger
• Swing-Away Winch Cathead Guard

Hazard Assessment

• Local Positioning System for Position-Time-Condition Correlation, Data-logging and Analysis
• Warning System for Mobile Machinery Hazardous Zones

Healthcare Associated Infection Prevention

• Methods to Regulate Biofilm Development to Prevent Infection on Indwelling or Implantable Medical Devices

Hearing Safety

• Hearing Safety Devices: System for Monitoring Exposure to Impulse Noise

Lead Detection and Removal

• Handwipe Disclosing Method for Detecting the Presence of Lead
• Wipes and Methods for Removal of Lead and Other Metal Contamination from Surfaces

Mining Safety

• Mining Safety: Personal Dust Monitor Filters for Accurate, Quantifiable Spectrometric Analysis and Assessment of…

Mosquito and Pest Control Devices

• A Bias-free Sampling and Collection Trap for Resting Mosquitoes
• CDC Mosquito Trap for Control and Surveillance of Mosquitoes Including Carriers of Zika & Other Viruses
• Entangling/Entrapping Synthetic Setae for Control of Insects and Other Pests

Pulmonary Assessment and Respirator Technology

• Device to Measure Muscle Contractile-Relaxant and Epithelial Bioelectric Responses of Perfused, Intact Tracheal…
• Improved Acoustic Plethysmograph System for Noninvasive Measurement of Pulmonary Function
• Methods and Apparatus for Computer-Aided Cough Sound Analysis
• Ultrasonic in situ Respirator Seal-Leakage Detection with Real-time Feedback Capabilities

Software, Algorithms, and Imaging

• Automated Microscopic Image Acquisition, Compositing and Display Software Developed for Applied Microscopy/Cytology…
• Method for Finding Usable Portion of Sigmoid Curve (the Taylor Method), Improved Assay Readouts, and Enhanced…
• Personalized Cancer Evaluation (PERCEVAL) Method and Software
• Virus Microneutralization Assay Data Analysis for Vaccine Development, Enhancement and Efficacy Improvement

Telemedicine

• Auscultatory Training System and Telemedicine Tool with Accurate Reproduction of Physiological Sounds

Therapeutic and Research Use

• Therapeutic, Bifunctional Janus Microparticles with Spatially Segregated Surface Proteins and Methods of Production…

Water Monitoring

• Monitoring Public Water Supply for a Variety of Pathogens

Aerosol Exposure

• Computer Controlled Aerosol Generator with Multi-Walled Carbon Nanotube Inhalation Testing Capabilities
• Non-radioactive, Miniature Bipolar Aerosol Particle Charger for Personal, Portable Instrumentation

Air Quality and Aerosol Analysis

• Diisocyanate Specific Monoclonal Antibodies for Occupational and Environmental Monitoring of Polyurethane Production Exposure-related Asthma and Allergy and Clinical Diagnosis
• Focused Electrostatic Collection of Aerosol Particles for Chemical Analysis by Spectroscopic Techniques
• Methods for Near Real-time Chemical Analysis of Aerosols using Microwave-induced Plasma Spectroscopy

• Mobile Instrumentation for the Detection and Sampling of Aerosol Particles

Bat Restraint

• Bat Restraint for Blood Sample Collection

Chemotherapy Contaminant Detection

• Direct Reading Detection Kits for Surface Contamination by Anti-Neoplastic (Anti-Cancer) Drugs

Counterfeit Drug Detection

• A Simple Colorimetric Assay for Anti-malarial Drugs Quality Assurance and Rapid, On-site Counterfeit Detection
• Portable Laser-Operated Counterfeit Drug Identifier (CoDI) for Tablets

Diagnostics

• Anthrax
  • Assay for Early Diagnosis of Anthrax Using Monoclonal Antibodies Against Anthrax Toxin
  • Exposure and Activity Detection Assays for Anthrax Lethal Factor and Lethal Toxin
  • Stable, Early-stage Biomarker for Diagnosis of Bacillus anthracis Infection and Anthrax Vaccine Development
• Antibiotic Resistance – Real-Time PCR Assay for Detection of Carbapenem Antibiotic Resistance Genes of the IMP-type
• Antifungal Resistance – DNA Probes to Rapidly Screen Candida glabrata Isolates for Echinocandin Resistance to Antifungal Treatment
• Bocavirus – Real-time PCR Assays for Human Bocavirus Detection and Diagnosis
• Botulism – Improved Botulism, Botulinum Neurotoxin Type-E Diagnostics
• Clostridium difficile (C. difficile), Bordetella pertussis, and more — Sensitive Method for Detection and Quantification of Anthrax, Bordetella pertussis, Clostridium difficile,…
• Dengue Virus
  • Chimeric Reporter West Nile/Dengue Viruses and Their Use for Assay Development
  • Monoclonal Antibodies for Specific Detection of Dengue Virus Sub-type 4 in Human Serum
  • Novel Method and Kit Using Monoclonal Antibodies for More Sensitive Detection of Dengue Virus
• Dengue/West Nile Viruses – High-Titer, Fast-Growth Chimeric Dengue/West Nile Viruses for Vaccine and Diagnostics Development
• Enterovirus
  • Enterovirus Molecular Diagnostic Test Kit
  • Real-time RT-PCR Assay for Rapid, Highly Sensitive and Specific Detection of Human Enterovirus D68 (EV-D68)
• Flavivirus
  • Discrete Cross-Reactive Epitopes for Flavivirus Serological Diagnostics and Vaccines
  • Recombinant Nucleic-Acid Based Flavivirus Nucleic Acids for Development of Vaccines and/or Sero-diagnostics
• Fungal Pathogens
  • Detection and Differentiation of Pathogenic Fungi in Clinical Samples Using a Multi-Analyte Profiling System
  • Nucleic Acid Assays for the Detection and Discrimination of Aspergillus Fungi Species within Biological Samples
  • Nucleic Acid Detection of the Fungal Pathogen Histoplasma capsulatum from Clinical and Environmental Samples
  • Nucleic Acid-based Compositions and Methods for the Detection of Pathogenic Candida or Aspergillus Fungi Species
  • Nucleic Acid-based Compositions and Methods for the Species-Specific Detection of Pathogenic Candida Fungi
  • Nucleic Acid-based Differentiation and Identification of Medically Important Fungi
  • Species-specific Nucleic Acid Detection Assay for Fungi
• Hepatitis C – Novel Enzyme-Based Immunoassay for Simultaneous Detection of Hepatitis C Virus Antigen and Antibody in Human Serum or Plasma
• Hepatitis E – Immunogenic Hepatitis E Virus Polypeptides for Vaccine and Diagnostics Development
• HIVDrug Resistant HIV – Rapid Detection of Antiretroviral(s) Drug-Resistant HIV-1 within Clinical Samples
• HIV – Composition and Methods for Rapid Detection of HIV by Loop-mediated Isothermal Amplification
  • HIV-1 – A Device for Simultaneous and Rapid Diagnosis and Detection of Recent and Long Term HIV-1 Infection
  • HIV-1 – HIV-1 BED: A Simple Serological Assay for Detecting Recent Infection and Estimating Incidence of Multiple, Worldwide HIV-1 Subtypes
  • HIV-1 – Monoclonal Antibodies to the HIV-1 Core Protein p24
  • HIV-1 – Simple and Rapid Assay to Detect Acute Subtype B and Group M HIV-1 Infections
  • HIV-1 and HIV-2 – Multivalent, Multiple-Antigenic-Peptides for Serological Detection of HIV-1 Groups -M, -N, -O, and HIV-2
  • HIV-1 and Retroviruses – Detection of Retroviruses and HIV-1 Groups -M and -O Discrimination within Clinical Serum Samples
  • HIV-1 and Simian Immunodeficiency Virus (SIV) – Molecular Detection and Viral-Load Quantification for HIV-1 Groups M, N and O, and Simian Immunodeficiency Virus-cpz (SIVcpz)
  • HIV-2 – On-site in vitro Diagnostic: Real-time Loop-Mediated Isothermal Amplification Detection of HIV-2 Groups A and B
  • HIV and SIV Type Retroviruses – Multiple Antigenic Peptide Assays for Detection of HIV and SIV Type Retroviruses
  • HIV Drug Adherence – Monoclonal Antibody to Detect the Antiretroviral Drug Emtricitabine – for HIV Drug Adherence Monitoring
• Influenza
  • Human Influenza Virus Real-time RT-PCR: Detection and Discrimination of Influenza A (H3N2) Variant from Seasonal Influenza A (H3N2) Viruses, Including H3v and Seasonal H3 Assays
  • Influenza A Virus Detection and Subtyping Directly from Animal Swabs and Environmental Samples
  • MDCK-based Reporter System for Detection of Influenza Viruses, Antiviral Drug Screening, and Analysis of Neutralizing Antibodies
  • Real-time RT-PCR assay for Detection of Live Attenuated Influenza Vaccine for A and B Viruses
  • The CDC 2009 Influenza A H1N1 (Flu) Pandemic Real-time RT-PCR Panel including Pandemic Influenza A and Pandemic H1 Assays
• Lyme Disease — Compositions and Methods for Improved Lyme Disease Diagnosis
• Malaria – Simple, Field-Usable Fluorescence-Based Isothermal LAMP Assay for the On-Site Diagnosis of Malaria
• Mass Spectrometry and Biomarker Analysis – Use of Detector Response Curves to Optimize Settings for Mass Spectrometry
• Phlebovirus – Diagnostics, Vaccines, and Delivery-Vehicles Related to Novel Phlebovirus
• Pneumonia
  • Antigen, Encoding Gene, Related Monoclonal Antibody and Hybridoma Clones for Streptococcus pneumoniae Serological Diagnostics
  • Encapsulated Streptococcus Compositions and Methods for Pneumococcal Vaccine, Probiotic, and Diagnostic Assay Development
  • Immunoassay for the Simultaneous Detection of Functional Antibodies against Multiple Serotypes of Streptococcus pneumoniae and Other Bacteria Types
  • Novel Peptide of Streptococcus pneumoniae Surface Adhesion A (PsaA) Protein Associated with Adherence and Uses Thereof – for Vaccine Candidate, Therapeutic and Diagnostic Development
  • Real-time PCR Detection of Streptococcus pneumoniae with High Sensitivity and Specificity
  • Simple and Rapid Loop-Mediated Isothermal Amplification (LAMP)-based Assay for Mycoplasma pneumoniae Detection
• Retrovirus (also above)
  • Detection of Retroviruses and HIV-1 Groups -M and -O Discrimination within Clinical Serum Samples
  • Human Retrovirus Obtained from Infected Chimpanzee Exposure
• Rickettsia – Real-Time RT-PCR Detection of Rickettsia species — PanR6/Total Nucleic Acid Assay with High Sensitivity and Specificity
• Rift Valley Fever – Real-time RT-PCR Assay for the Detection of Rift Valley Fever Virus in Humans and Livestock
• Rotavirus – Controlled Expression and Assembly of Human Group-C Rotavirus-like Particles for Creation of Rotavirus Diagnostic Assays and Improved Vaccine Formulations
• Scrub Typhus – Real-Time RT-PCR Detection of Scrub Typhus Total Nucleic Acid Assay with High Sensitivity and Specificity
• Syphilis
  • Cardiolipin Modification for Immunoassay Detection of Syphilis
  • Diagnostic Assay with Modified Cardiolipin for Detecting Active Syphilis Infections
  • Immunoassays and Methods to Diagnose Syphilis by Immobilizing a Lipoidal Antigen on a Solid Support
  • Methods for Detecting Syphilis Using Synthetic Antigens
• Tuberculosis – Diagnostic Antigens for the Identification of Latent Tuberculosis Infection
• Water Pathogens – Monitoring Public Water Supply for a Variety of Pathogens
• Zika Virus
  • Chimeric Dengue/Zika Viruses for Live-Attenuated Zika Vaccine Development (and Diagnostics)
  • Monoclonal Antibodies that Bind Zika Virus Envelope Protein for Zika Diagnostics and Research
  • Rapid Colorimetric Detection of Zika Virus from Serum and Urine Specimens by RT-LAMP (Reverse Transcription Loop-Mediated Isothermal Amplification).
  • West Nile/Zika Virus Chimeras for Inactivated Zika Vaccine and Diagnostic Assay Development
  • Zika Virus NS1 Protein Monoclonal Antibodies for Research, Development, and Novel Diagnostics

Diagnostics/Laboratory Other

• Fluorescent Primer(s) Creation for Nucleic Acid Detection and Amplification
• Generation of Artificial Mutation Controls for Diagnostic Testing
• Method to remove human DNA when sequencing for parasite infection
• Method to Remove Mycoplasma Contamination from Virus Stocks
• Methods for the Simultaneous Detection of Multiple Analytes
• Methods of Retaining Methylation Pattern Information in Globally Amplified DNA
• Multiplexed Immunoassay for Rapid Serological Diagnosis of a Specific Viral Infection in Clinical Samples
• Newborn Screening – Multiplexing Homocysteine in Primary Newborn Screening Assays Using Maleimides as Select Derivatization Agents
• Novel Inactivated Zika Vaccine Candidate Based on Purified Wild-type Zika Virus — for Zika Vaccine and Diagnostic Assay Development
• Novel UNEX Buffer and Disk for Safe Storage and Transport at Ambient Temperatures of Clinical Specimens for Molecular Testing of Pathogens
• Nucleic Acid Amplification Technique for Rapid Diagnostic Analysis
• One-step random amplification method to detect extremely low input nucleic acids for virome, microbiome, and metagenomics in clinical and biological specimens
• Photoinduced Electron Transfer Fluorescent Primer for Nucleic Acid Amplification
• Rapid Method for the Detection of Antigen-Specific Antibodies in Any Species

Drug Delivery

• Intranasal Nebulizer with Disposable Drug Cartridge for Improved Delivery of Vaccines and Therapeutics

Ergonomic and Musculoskeletal Injury Prevention

• Occupational Safety: Portable Exposure Assessment System for Prevention of Musculoskeletal Injury

Fall Prevention

• Extension-Ladder Safety: Multimodal-feedback Indicator for Improved Ladder Positioning Safety and Efficiency

Fishing and Maritime Safety

• Emergency Maritime Battery Charger
• Swing-Away Winch Cathead Guard

Hazard Assessment

• Local Positioning System for Position-Time-Condition Correlation, Data-logging and Analysis

Healthcare Associated Infection (HAI) Prevention

• Methods to Regulate Biofilm Development to Prevent Infection on Indwelling or Implantable Medical Devices

Hearing Safety

• Hearing Safety Devices: System for Monitoring Exposure to Impulse Noise

Lead Detection and Removal

• Lead Detection Wipes for Potentially Contaminated Surfaces
• Lead Removal Wipes – *please contact TTO@cdc.gov for more information.

Mining Safety

• Mining Safety: Personal Dust Monitor Filters for Accurate, Quantifiable Spectrometric Analysis and Assessment of…

Mosquito and Pest Control Devices

• A Bias-free Sampling and Collection Trap for Resting Mosquitoes
• CDC Mosquito Trap for Control and Surveillance of Mosquitoes Including Carriers of Zika & Other Viruses
• Entangling/Entrapping Synthetic Setae for Control of Insects and Other Pests

Pulmonary Assessment and Respirator Technology

• Device to Measure Muscle Contractile-Relaxant and Epithelial Bioelectric Responses of Perfused, Intact Tracheal…
• Improved Acoustic Plethysmograph System for Noninvasive Measurement of Pulmonary Function
• Methods and Apparatus for Computer-Aided Cough Sound Analysis
• Ultrasonic in situ Respirator Seal-Leakage Detection with Real-time Feedback Capabilities

Software, Algorithms, and Imaging

• Automated Microscopic Image Acquisition, Compositing and Display Software Developed for Applied Microscopy/Cytology…
• Method for Finding Usable Portion of Sigmoid Curve (the Taylor Method), Improved Assay Readouts, and Enhanced…

Telemedicine

• Auscultatory Training System and Telemedicine Tool with Accurate Reproduction of Physiological Sounds

Vaccines and/or Therapeutics Research

• Flavivirus –
  • Discrete Cross-Reactive Epitopes for Flavivirus Serological Diagnostics and Vaccines
  • Polypeptides and Methods for Enhancing and Balancing Monovalent or Multivalent Flavivirus Vaccines
  • Recombinant Nucleic-Acid Based Flavivirus Nucleic Acids for Development of Vaccines and/or Sero-diagnostics
• Infections By Intracellular Pathogens (e.g., viruses, bacteria, and parasites) – Vaccine Attenuation via Deoptimization of Synonymous Codons
• lnfluenza – Improved Protein Quantification Process and Vaccine Quality Control Production
• Pathogen-associated Inflammatory Response – Methods for Amelioration and Treatment of Pathogen-associated Inflammatory Response
• Phlebovirus – Diagnostics, Vaccines, and Delivery-Vehicles Related to Novel Phlebovirus
• Pneumonia
  • Encapsulated Streptococcus Compositions and Methods for Pneumococcal Vaccine, Probiotic, and Diagnostic Assay Development
  • Multi-Antigenic Peptide(s) Vaccine and Immunogen for Conferring Streptococcus pneumoniae Immunity
  • Novel Peptide of Streptococcus pneumoniae Surface Adhesion A (PsaA) Protein Associated with Adherence and Uses Thereof – for Vaccine Candidate, Therapeutic and Diagnostic Development
• Rabies – Antibodies for Rabies Post-exposure Prophylaxis or Antiviral Therapy of Clinical Rabies
• Respiratory Syncytial Virus (RSV) – Respiratory Syncytial Virus (RSV) Immunogens for Vaccine and Therapeutics Development
• Rift Valley Fever
  • Novel Rift Valley Fever Virus Vaccines
  • Virus Replicon Particles as Rift Valley Fever Vaccines
• Rotavirus
  • Human Rotavirus Strains and Vaccines for Neonatal Childhood Protection
  • Novel Human Rotavirus Vaccine CDC-6 Strain for Impacted Subgroup, the Lewis Negative Population
• Therapeutics/Protein Research – Therapeutic, Bifunctional Janus Microparticles with Spatially Segregated Surface Proteins and Methods of Production…
• Tuberculosis
  • Novel In Vitro Granuloma Model for Studying Tuberculosis and Drug Efficacy
  • Select tuberculosis Peptides as Mucosal Vaccines Against Pulmonary Tuberculosis
• West Nile Virus – High-Titer, Fast-Growth Chimeric Dengue/West Nile Viruses for Vaccine and Diagnostics Development
• Zika – Chimeric Dengue/Zika Viruses for Live-Attenuated Zika Vaccine Development

Water Monitoring

• Monitoring Public Water Supply for a Variety of Pathogens

CDC illustration, Alissa Eckert.

Bat Restraint for Blood Sample Collection

• CDC researchers developed a proof-of-concept bat restraint and successfully used it. Collaborators designed a prototype and produced 3D printed model iterations.
• The adapted device reduces the potential risks of needle sticks to researchers, reduces the stress on the animal, and increases the efficiency of blood collection and blood sample quality.
• The restraint lessens the need for bat manipulation and enables a safer and more efficient collection of blood performed by a single individual.

CDC PHIL photo, Cynthia Goldsmith.

Stable Human Cell Lines Expressing Flavivirus Virus-Like Particles (VLPs) for Vaccine, Biologics, and Diagnostic Development

• CDC has identified and characterized distinct flavivirus cross-reactive epitopes (specific pieces of the antigen to which an antibody binds) that can improve serodiagnosis and vaccination against flaviviruses.
• CDC’s new flavivirus VLPs have structural proteins as the basis to form the viral particles. They do not have a viral genome so they are non-infectious.

CDC PHIL photo, Dan Higgins.

Encapsulated Streptococcus Compositions and Methods for Pneumococcal Vaccine, Probiotic, and Diagnostic Assay Development

• CDC has discovered encapsulated strains of commensal Streptococcus species, mitis, S. oralis, and S. infantis, which have capsules that are identical to pneumococcal capsules. From this, researchers developed compositions and methods from the species’ biosynthetic capsular genes.
• The technology shows promise for protecting people against pneumococcal disease, either by using these strains as vaccines or probiotics, or through development of diagnostic assays.
• Initial results show cross-protection against eight pneumoniae serotypes, including serotype 1, a leading cause of invasive pneumococcal disease globally outside of the US.
• Initial concept studies have been performed in animal models.

Photo credit: CDC Photo Services.

Monitoring Public Water Supply for a Variety of Pathogens

• CDC has combined two techniques, ultrafiltration (UF) and insulator-based dielectrophoresis (iDEP) in series, to achieve significant concentration of microbes and pathogens for analysis.
• UF can concentrate a water sample ≥200X, depending on turbidity; if a secondary concentration step is applied, then a ≥25,000X can be achieved.
• This technology may be used for monitoring of municipal, commercial, public, and individual water supplies for drinking water quality as well as additional applications.

Potential counterfeit drugs. iStock photo.

Portable Laser-Operated Counterfeit Drug Identifier (CoDI) for Tablets

• Portable Laser-Operated Counterfeit Drug Identifier (CoDI) for Tablets.
• CDC researchers developed a portable (handheld), battery-operated, and relatively inexpensive device that non-trained personnel can use quickly to evaluate a particular branded tablet for authenticity.
• The instrument can detect counterfeit, degraded, and expired drugs in tablet formation.
• CDC researchers successfully tested the CoDI prototype in Ghana on a project to detect falsified, degraded, and expired ingredients in antimalarial tablets. Field trials to test additional drug samples are underway.

Photo depicts an Aedes species mosquito. CDC photo, James Gathany.

CDC Mosquito Trap for Control and Surveillance of Aedes Mosquitoes Including
Carriers of Zika, Dengue, Yellow Fever, Chikungunya and Other Viruses

• CDC researchers developed the autocidal gravid ovitrap (AGO) device that targets older female mosquitoes looking for a place to lay eggs.
• CDC and the Puerto Rico Department of Health are implementing large-scale installation of AGO traps throughout several communities to reduce mosquito populations and the viruses they spread after successful field trials.
• Traps can be used for surveillance and control of Aedes aegypti and Ae. albopictus mosquitoes.