Vaccine Safety

V-safe after vaccination checker header

Get started with v-safe

Enroll in v-safe and tell CDC how you, or your dependent,
feel after getting a COVID-19 or monkeypox vaccine.

The United States currently has the safest vaccine supply in its history. The nation’s long-standing vaccine safety system ensures that vaccines are as safe as possible.

As vaccines are developed and become available, the public’s knowledge of their safety, both initially and during extended use, is an important part of a successful national vaccination effort.

CDC’s Immunization Safety Office works to communicate timely and transparent information about the safety of vaccines to public health officials, healthcare providers, and the public. The office conducts vaccine safety monitoring and clinical research to help keep vaccines safe.

Report a Possible Health Problem following
Vaccination to VAERS

Everyone is encouraged to report possible health problems (adverse events) after vaccination to the Vaccine Adverse Event Reporting System (VAERS). Healthcare providers and vaccine manufacturers are required to report certain health events.>

Request a COVID-19 CISA Clinical Consultation

Healthcare providers or health departments in the United States can request a consultation for complex COVID-19 vaccine safety questions from CISA COVIDvax.

COVID-19 Vaccine Safety
illustration of a vial containing COVID-19 vaccine and a green check mark

Vaccine safety is a vital part of the nation’s response to the COVID-19 pandemic.

screenshot top of VAERS hompage

The Vaccine Adverse Event Reporting System (VAERS) serves as the nation’s early warning system to monitor for potential vaccine safety problems. Anyone can report possible health problems to VAERS.

VSD map

The Vaccine Safety Datalink (VSD) is a collaboration between CDC and 13 health care organizations that conducts active vaccine safety monitoring and research.

CISA Project
CISA Project Map

The Clinical Immunization Safety Assessment (CISA) Project is a partnership between CDC and 7 medical research centers that provides expert consultation and conducts clinical research on vaccine-associated health risks.

COVID-19 Vaccine Information

For clinicians:
COVID-19 Vaccine Product Information
Key information for each specific COVID-19 vaccine including administration, storage and handling, safety, and reporting.

For the general public:
COVID-19 Vaccine Information Overview
Overview of what everyone should know about the different COVID-19 vaccines.
COVID-19 vaccine factsheets:
COVID-19 Vaccine Emergency Use Authorization (EUA) Fact Sheets for Recipients and Caregivers
Fact sheets for each COVID-19 vaccine authorized under the Emergency Use Authorization (EUA).
Vaccine Safety Protocols

For the COVID-19 response, CDC’s vaccine safety experts have developed protocols and standard operating procedures to guide COVID-19 vaccine safety monitoring efforts.