Vaccine Safety

V-safe Update: Enrollment in v-safe for COVID-19 vaccines closed on May 19, 2023. Previously enrolled participants may continue to access their accounts to complete health check-ins and review previous entries until June 30, 2023. Although COVID-19 vaccine safety monitoring in v-safe has ended, CDC will continue to monitor the safety of COVID-19 vaccines through its other vaccine safety monitoring systems.

Thank you to everyone who contributed to the success of v-safe.

The United States currently has the safest vaccine supply in its history. The nation’s long-standing vaccine safety system ensures that vaccines are as safe as possible.

As vaccines are developed and become available, the public’s knowledge of their safety, both initially and during extended use, is an important part of a successful national vaccination effort.

CDC’s Immunization Safety Office works to communicate timely and transparent information about the safety of vaccines to public health officials, healthcare providers, and the public. The office conducts vaccine safety monitoring and clinical research to help keep vaccines safe.

COVID-19 Vaccine Safety
illustration of a vial containing COVID-19 vaccine and a green check mark

Vaccine safety is a vital part of the nation’s response to the COVID-19 pandemic.

screenshot top of VAERS hompage

The Vaccine Adverse Event Reporting System (VAERS) serves as the nation’s early warning system to monitor for potential vaccine safety problems. Anyone can report possible health problems to VAERS.

VSD map

The Vaccine Safety Datalink (VSD) is a collaboration between CDC and 13 health care organizations that conducts active vaccine safety monitoring and research.

CISA Project
CISA Project Map

The Clinical Immunization Safety Assessment (CISA) Project is a partnership between CDC and 7 medical research centers that provides expert consultation and conducts clinical research on vaccine-associated health risks.

COVID-19 Vaccine Information

For clinicians:
COVID-19 Vaccine Product Information
Key information for each specific COVID-19 vaccine including administration, storage and handling, safety, and reporting.

For the general public:
COVID-19 Vaccine Information Overview
Overview of what everyone should know about the different COVID-19 vaccines.
COVID-19 vaccine factsheets:
COVID-19 Vaccine Emergency Use Authorization (EUA) Fact Sheets for Recipients and Caregivers
Fact sheets for each COVID-19 vaccine authorized under the Emergency Use Authorization (EUA).
Vaccine Safety Protocols:
Protocols and standard operating procedures to guide CDC’s COVID-19 vaccine safety monitoring efforts.