Opioid Use Disorder: Diagnosis

What to know

  • Identification of opioid use disorder (OUD) is an opportunity for clinicians to initiate potentially life-saving interventions.
  • Clinicians should collaborate with the patient regarding their safety to increase the likelihood of successful treatment.
  • Treatment with opioids for pain is associated with increased risk for OUD, particularly if opioids are prescribed for more than 90 days.
Clinician and patient talking at a desk and reviewing a paper.

Identifying OUD

If clinicians are concerned and suspect their patient may have OUD, they should discuss the concerns with the patient in a nonjudgmental manner. Clinicians can provide an opportunity for patients to disclose related concerns or problems. Concerns about OUD may be informed by

  • Patient stated concerns
  • Patient behavior
  • Findings in prescription drug monitoring program (PDMP) data
  • Results of toxicology testing

Clinicians should assess for the presence of OUD using the following checklist based on the DSM-5 criteria.

Diagnostic criteria

OUD is demonstrated by at least 2 out of the 11 criteria below occurring within a year. Severity of OUD is determined based on the number of criteria met.A

  • Mild: 2-3 criteria
  • Moderate: 4-5 criteria
  • Severe: greater than or equal to 6 criteria

Diagnostic CriteriaB

  • Taking opioids in larger amounts or over a longer period of time than intended
  • Having a persistent desire or unsuccessful attempts to reduce or control opioid use
  • Spending excess time obtaining, using, or recovering from opioids
  • Craving opioids
  • Continued opioid use causing inability to fulfill work, home, or school responsibilities
  • Continuing opioid use despite having persistent social or interpersonal problems
  • Lack of involvement in social, occupational, or recreational activities
  • Using opioids in physically hazardous situations
  • Continuing opioid use in spite of awareness of persistent physical or psychological problems
    • a. A need for markedly increased amounts of opioids to achieve intoxication or desired effect, or
    • b. Markedly diminished effect with continued use of the same amount of an opioid.
  • Exhibiting withdrawal symptoms, as manifested by either of the following:*
    • a. The characteristic opioid withdrawal syndrome, or
    • b. Opioids (or a closely related substance) are taken to relieve or avoid withdrawal symptoms.

*Tolerance and withdrawal are not considered to be met for those taking opioids solely under appropriate medical supervision.

  1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington, VA: American Psychiatric Publishing; 2013.
  2. This the criteria is adapted and has been edited for plain language from the American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington, VA: American Psychiatric Publishing; 2013.