Rhabdomyolysis

Risk Factors for Rhabdomyolysis

Key points

  • Anyone can get rhabdomyolysis (rhabdo), but some workers are at a higher risk than others.
  • Working in hot environments can increase workers' chances of getting rhabdo.
  • Physically demanding work can put workers at increased risk.
  • We currently do not know all the rhabdo risk factors.
Military personnel exercising outside, sweating

What increases risk

Firefighters wearing PPE, carrying gear, near large flames.
Performing physical tasks in hot environments increase rhabdo risk.

Anyone can get rhabdo, but some workers are at a higher risk than others. People who work in hot environments or perform strenuous physical tasks have a higher chance of getting rhabdo.

Common causes of rhabdo in the workplace

High body temperature

Hot work conditions can increase your likelihood of developing rhabdo. This includes:

  • Working outdoors or in hot environments
  • Working in or near hot processes (e.g., asphalt pavers)
  • Wearing personal protective equipment (PPE) can trap body heat

For example, structural firefighters wear heavy coats and pants. This PPE can trap body heat. This can increase their risk of rhabdo.

Overuse of muscles

People who work physically demanding jobs have a greater chance of developing rhabdo. This includes jobs that involve:

  • High levels of physical exertion
  • Prolonged periods of physical exertion
  • High intensity workouts
  • Physical fitness tests

Physical damage to muscles

Any work that could potentially result in traumatic injuries (such as falls from heights or car accidents) puts workers at a higher risk for rhabdo.

Workers at increased risk

  • Firefighters (both structural and wildland)
  • Police officers
  • First responders
  • Outdoor workers (e.g., farmers, roofers, construction workers, landscapers, national park employees)
  • Workers in hot environments (e.g., forge or smelter workers)
  • Military service members
  • Athletes

Attention structural and wildland firefighters!‎

Download one of the wallet cards below and show it to your healthcare provider if you're experiencing any rhabdo symptoms. This card will remind your healthcare provider about your increased risk for rhabdo.

Structural Firefighters

Wildland Firefighters

Conditions that can increase risk

Examples of conditions that can increase your risk include:

Behaviors that can increase risk

Examples of behaviors that can increase risk include:

  • Using illegal drugs such as cocaine and methamphetamine
  • Drinking excessive alcohol
  • Taking supplements such as creatine and ephedra
  • Consuming large amounts of caffeine or other stimulants

Medications that can increase risk

Examples of medications that can increase your risk include:

  • Some antibiotics (e.g., erythromycin)
  • Some antidepressants (e.g., tricyclic antidepressants)
  • Cholesterol-lowering drugs (e.g., statins)
  • Some cold and allergy medicines (e.g., antihistamines, decongestants)