Diagnostics and Chemical Markers of Exposure
The Organic Analytical Toxicology Branch develops and performs unique laboratory tests to measure organic environmental chemicals in people. Examples of available laboratory tests are shown in the table above. It lists the most common names for these chemicals, and their Chemical Abstracts Service (CAS) Registry Numbers. Many of the chemicals, however, go by alternative names. Please visit the National Library of Medicine ChemID database websiteExternal and enter the chemical’s CAS Number. The page displayed after this search will include the chemical’s structure, and alternative names.
Laboratory Methods Panels
CDC’s laboratory methods are intended to evaluate population exposures and to support states in situations considered a public health concern. Please see the “Methods’ Access” tab in the tables found after clicking on each of the listed chemicals for additional information regarding these methods. Currently, CDC’s Organic Analytical Toxicology Branch does not have the capability of generating pilot or preliminary results in support of proposals to obtain public or private funds for a larger project.
CAS No. 134-62-3
CAS No. 858981-15-4
CAS No. 72236-22-7
Laboratory Method: https://www.cdc.gov/nchs/data/nhanes/nhanes_09_10/DEET_F_met.pdfCdc-pdf
Urinary biomarkers of exposure to insecticides, herbicides, and one insect repellent among pregnant women in Puerto Rico
Lewis RC, Cantonwine DE, Anzalota Del Toro LV, Calafat AM, Valentin-Blasini L, Davis MD, Baker SE, Alshawabkeh AN, Cordero JF, Meeker JD Environ Health. 2014 Nov 19;13(1):97. [Epub ahead of print]
Queensland, Australia, using pooled urine samples
Heffernan AL, English K, Toms L, Calafat AM, Valentin-Blasini L, Hobson P, Broomhall S, Ware RS, Jagals P, Sly PD, Mueller JF.
Environ Sci Pollut Res Int. 2016 Dec;23(23):23436-23448. Epub 2016 Sep 10.
Novel exposure biomarkers of N,N-diethyl-m-toluamide (DEET): Data from the 2007-2010 National Health and Nutrition Examination Survey
Calafat AM, Baker SE, Wong LY, Bishop AM, Morales-A P, Valentin-Blasini L.
Environ Int. 2016 Jul-Aug;92-93:398-404. doi: 10.1016/j.envint.2016.04.021. Epub 2016 Apr 30.
On-line solid phase extraction-high performance liquid chromatography-isotope dilution-tandem mass spectrometry approach to quantify N,N-diethyl-m-toluamide and oxidative metabolites in urine
Kuklenyik P, Baker SE, Bishop AM, Morales-A P, Calafat AM.
Anal Chim Acta. 2013 Jul 17;787:267-73. doi: 10.1016/j.aca.2013.05.055. Epub 2013 Jun 6.
Biomonitoring Factsheet: Dichlorodiphenyltrichloroethane (DDT)
DEET Factsheet: https://www.cdc.gov/malaria/toolkit/DEET.pdfCdc-pdf
CDC’s laboratory methods are intended to evaluate population exposures and to support states in situations considered a public health concern. CDC does not provide individual health care or assessment unless as part of a broader public health investigation requested by federal or state agencies, such as a health department. Currently, CDC’s Organic Analytical Toxicology Branch does not have the capability of generating pilot or preliminary results in support of proposals to obtain public or private funds for a larger project.
Detecting levels of an environmental chemical in a person’s blood or urine does not necessarily mean the chemical will cause adverse health effects or disease. Advances in analytical methods enable CDC to measure very low levels of environmental chemicals in people, but research studies of varying levels of exposure are needed to determine if specific levels cause health effects. Consulting a clinician with a toxicological background to assist with the interpretation of results is recommended.
Samples to be tested should be processed through a state health department laboratory, and should conform to the laboratory’s reporting procedures. These laboratory methods often require that the sample be collected by a particular method, or sometimes with particular pre-screened collection devices, to minimize external contamination. Following the correct sample collection protocol is necessary for accurate sample measurement. Please contact the laboratory that will be analyzing the sample to learn the sample collection instructions before collecting the samples.
Contact DLSLab@cdc.gov for more information or questions about these laboratory methods.