Diagnostics and Chemical Markers of Exposure
The Organic Analytical Toxicology Branch develops and performs unique laboratory tests to measure organic environmental chemicals in people. Examples of available laboratory tests are shown in the table above. It lists the most common names for these chemicals, and their Chemical Abstracts Service (CAS) Registry Numbers. Many of the chemicals, however, go by alternative names. Please visit the National Library of Medicine ChemID database websiteexternal icon and enter the chemical’s CAS Number. The page displayed after this search will include the chemical’s structure, and alternative names.
Laboratory Methods Panels
CDC’s laboratory methods are intended to evaluate population exposures and to support states in situations considered a public health concern. Please see the “Methods’ Access” tab in the tables found after clicking on each of the listed chemicals for additional information regarding these methods. Currently, CDC’s Organic Analytical Toxicology Branch does not have the capability of generating pilot or preliminary results in support of proposals to obtain public or private funds for a larger project.
CAS No. 298-06-6
CAS No. 598-02-7
CAS No. 5871-17-0
CAS No. 298-06-6
CAS No. 813-78-5
CAS No. 813-78-5
The presence of dialkylphosphates in fresh fruit juices: implication for organophosphorus pesticide exposure and risk assessments
Lu C, Bravo R, Caltabiano LM, Irish RM, Weerasekera G, Barr DB
Journal article published in Journal of Toxicology and Environmental Health Part A, 2005.
Distribution and determinants of urinary biomarkers of exposure to organophosphate insecticides in Puerto Rican pregnant women
Lewis RC, Cantonwine DE, Anzalota Del Toro LV, Calafat AM, Valentin-Blasini L, Davis MD, Montesano MA, Alshawabkeh AN, Cordero JF, Meeker JD.
Sci Total Environ. 2015 Apr 15;512-513:337-344. doi: 10.1016/j.scitotenv.2015.01.059. Epub 2015 Jan 27.
Impact of low-level gestational exposure to organophosphate pesticides on neurobehavior in early infancy: a prospective study
Yolton K, Xu Y, Sucharew H, Succop P, Altaye M, Popelar A, Montesano MA, Calafat AM, Khoury JC.
Environ Health. 2013 Sep 13;12(1):79. doi: 10.1186/1476-069X-12-79.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848803/pdf/1476-069X-12-79.pdfpdf iconexternal icon
Associations of prenatal exposure to organophosphate pesticide metabolites with gestational age and birth weight
Rauch SA, Braun JM, Barr DB, Calafat AM, Khoury J, Montesano AM, Yolton K, Lanphear BP.
Environ Health Perspect. 2012 Jul;120(7):1055-60. doi: 10.1289/ehp.1104615. Epub 2012 Apr 5.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404666/pdf/ehp.1104615.pdfpdf iconexternal icon
Urinary Concentrations of Insecticide and Herbicide Metabolites among Pregnant Women in Rural Ghana: A Pilot Study
Wylie BJ, Ae-Ngibise KA, Boamah EA, Mujtaba M, Messerlian C, Hauser R, Coull B, Calafat AM, Jack D, Kinney PL, Whyatt R, Owusu-Agyei S, Asante KP.
Int J Environ Res Public Health. 2017 Mar 29;14(4). pii: E354. doi: 10.3390/ijerph14040354.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409555/pdf/ijerph-14-00354.pdfpdf iconexternal icon
Biomonitoring Factsheet: Organophosphorus Insecticides: Dialkyl Phosphate Metabolites
CDC’s laboratory methods are intended to evaluate population exposures and to support states in situations considered a public health concern. CDC does not provide individual health care or assessment unless as part of a broader public health investigation requested by federal or state agencies, such as a health department. Currently, CDC’s Organic Analytical Toxicology Branch does not have the capability of generating pilot or preliminary results in support of proposals to obtain public or private funds for a larger project.
Detecting levels of an environmental chemical in a person’s blood or urine does not necessarily mean the chemical will cause adverse health effects or disease. Advances in analytical methods enable CDC to measure very low levels of environmental chemicals in people, but research studies of varying levels of exposure are needed to determine if specific levels cause health effects. Consulting a clinician with a toxicological background to assist with the interpretation of results is recommended.
Samples to be tested should be processed through a state health department laboratory, and should conform to the laboratory’s reporting procedures. These laboratory methods often require that the sample be collected by a particular method, or sometimes with particular pre-screened collection devices, to minimize external contamination. Following the correct sample collection protocol is necessary for accurate sample measurement. Please contact the laboratory that will be analyzing the sample to learn the sample collection instructions before collecting the samples.
Contact DLSLab@cdc.gov for more information or questions about these laboratory methods.