Notes from the Field: Dengue Outbreak — American Samoa, 2025–2026

Investigation and Outcomes

Case Definitions

Suspected dengue cases, defined as the presence of fever plus one or more additional manifestation,* were reported to the American Samoa Department of Health (ASDOH) for confirmatory testing and travel history assessment. Patients with confirmed dengue cases had dengue like symptoms and positive blood test results by one or more of the following tests: 1) nonstructural protein 1 (NS1) antigen enzyme-linked immunosorbent assay (ELISA), 2) immunoglobulin M (IgM) ELISA, 3) reverse transcription–polymerase chain reaction (RT-PCR), or 4) a rapid dengue test^† at the ASDOH Public Health Laboratory (1). A subset of confirmed cases underwent DENV serotyping by RT-PCR testing at the State of Hawaii, Department of Health, Public Health & Environmental Laboratories.^§ Patients with travel-associated cases were those who reported travel outside of American Samoa during the 14 days preceding symptom onset; cases in patients with no recent travel were classified as locally acquired. This outbreak investigation was reviewed by CDC, deemed not research, and conducted consistent with applicable federal law and CDC policy.^¶

Characteristics of Patients with Dengue

During June 2025–August 2026, a total of 1,048 confirmed dengue cases were identified (incidence = 211 cases per 10,000 population**). The majority of cases occurred among persons aged <20 years (814; 78%) and among males (650; 62%) (Supplementary Table). Incidence was highest among children aged 10–14 years (652 per 10,000). Overall, 49 (5%) cases were classified as travel associated, and 999 (95%) were locally acquired. A total of 371 (35%) patients required hospitalization; none died. The weekly number of hospital admissions peaked in December 2025 at 19 (median = 6; IQR = 4–9). On the day of highest occupancy, 18 of 110 (16%) available hospital beds^†† were occupied by patients with dengue. The median length of hospitalization was 4 days (IQR = 3–5 days). Among all cases, 99% were confirmed using NS1 ELISA (838; 80%) or RT-PCR testing (204; 19%). Two cases were confirmed by IgM ELISA only and four by rapid test only. Among 146 serotyped cases, DENV-1 was identified in 136 (93%) and DENV-2 in 10 (7%).

Temporal and Geographic Distributions of Cases

Case counts increased during June–August 2025; among 97 of these early cases, 38 (39%) were travel associated (Figure); however, during September 2025–February 2026, travel-associated cases accounted for 1% of all cases (11 of 783), consistent with sustained local transmission. No travel-associated cases were identified after February 15, 2026, and case counts consistently declined during February–August. Among American Samoa’s 76 villages, 54 (71%) reported at least one dengue case, with the highest number (152; 15%) reported in Tafuna, the most populous village on the island.

Preliminary Conclusions and Actions

In July 2025, ASDOH issued a dengue health alert that included recommendations for preventing mosquito bites while traveling and monitoring symptoms after returning. Because diagnostic testing was available on the island during this outbreak, the first dengue cases were confirmed within days rather than weeks, as was the case during previous outbreaks, when all samples had to be transported to Hawaii for dengue testing. In August 2025, CDC staff members provided dengue clinical management training to local health care professionals. Administrators updated the hospital’s surge plan to reallocate personnel and clinical space as needed to accommodate increased numbers of dengue cases. The American Samoa Environmental Protection Agency simultaneously led community cleanup campaigns to reduce Aedes species mosquito breeding sites and populations, resulting in the transport of approximately 250 large loads of household waste to the municipal landfill. ASDOH sprayed residual (long-lasting) insecticide at 52 day care centers, 33 public schools, 13 private schools, 11 government offices, six community health centers, five churches, one private business, and the hospital. Indoor residual spraying and outdoor residual spraying were offered to households of patients with dengue within 1–2 days of dengue diagnosis and to neighbors living within 164 ft (50 m) of affected residences.^§§ As of June 15, 2026, among 740 households that could be reached by telephone, 716 (97%) had received outdoor residual spraying, and 297 (40%) had received indoor residual spraying. Beginning in March 2026, spatial emanators,^¶¶ devices that passively emit a fast-acting insecticide called transfluthrin, were offered to households that declined indoor residual spraying; 422 spatial emanators were distributed to 77 households (an average of 5.5 per household), and 331 were installed in schools.

This is the first dengue outbreak for which American Samoa used on-island laboratory diagnostic testing to strengthen case identification. On-island laboratory diagnostic testing can be considered as an effective strategy to confirm DENV infections and guide rapid deployment of local vector control tools in future dengue outbreaks. Dengue surveillance and timely case reporting can guide outbreak response by facilitating the development and implementation of vector control tools and expediting clinical training when DENV transmission is identified.