Appendix for CDC Operational Guidance for Investigating Locally Acquired Mosquito-Transmitted Malaria — United States, 2026

Recommendations and Reports / May 21, 2026 / 75 (1);1–14

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APPENDIX Malaria Messaging and Resources for Community Partners

Examples of General Malaria Messaging

Malaria is a mosquitoborne disease caused by a parasite. Persons with malaria often experience fever, chills, and flu-like illness. Severe complications and death can occur if left untreated.
The United States reports approximately 2,000 cases of malaria each year. Most of these cases are travel-associated malaria (“imported” malaria) and occur in travelers returning from countries where malaria is still widespread (endemic).
The Anopheles mosquitoes that transmit malaria are present across the United States. Areas with Anopheles mosquitoes and imported malaria cases are at higher risk for local malaria transmission.
If a person in the United States already has malaria and is then bitten by an Anopheles mosquito, the mosquito can become infectious and could transmit the parasite to other persons in the area. The source of these locally acquired mosquito-transmitted malaria cases is likely related to an imported or travel-associated case of malaria.
The most effective way to prevent malaria in the United States is to prevent mosquito bites and ensure early diagnosis and treatment of imported cases. Travelers to malaria-endemic areas should take recommended steps to prevent acquiring malaria while traveling, including taking medications to prevent malaria.

Potential Media Inquiry Questions

When was the last time locally acquired (mosquito-transmitted) malaria was detected in my area or the United States?
Should we (the community) be concerned?
Where was the recent case?
What can I do to prevent getting locally acquired (mosquito-transmitted) malaria? (How does it spread?)
What are you doing to prevent the spread of locally acquired (mosquito-transmitted) malaria?
What should someone do if they think they have malaria?
How can we ensure the blood supply is safe?

Examples of Media Press Releases

Clinician Education and Outreach Resources

Locally Acquired Malaria Cases Identified in the United States | CDC Health Alert Network
Important Updates on Locally Acquired Malaria Cases Identified in Florida, Texas, and Maryland | CDC Health Alert Network
Malaria 101 for the Healthcare Provider | CDC (Continuing Medical Education, Continuing Nursing Education, and Continuing Education Units are available)
Review of Malaria Diagnosis and Treatment in the United States | CDC
Clinical Guidance: Malaria Diagnosis & Treatment in the U.S. | CDC

Community Outreach Resources

Locally Transmitted Malaria Outbreak Reports

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