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Extramural Research

The National Center for Injury Prevention and Control (NCIPC) Extramural Research Program Office (ERPO) facilitates extramural research prioritization, planning, and evaluation for both NCIPC and the National Center for Environmental Health/Agency for Toxic Substances and Disease Registry; and ensures their extramural research portfolios are designed for maximum public health impact.

Current Research Highlight

Research to Prevent Prescription Opioid Overdose

View of a doctor's hands holding a pill bottle

NCIPC-supported research is providing information and tools to improve the safety and effectiveness of opioid prescribing and pain management.

  • Oregon State University researchers looked at opioid prescribing in the Oregon state Medicaid program and found the top 10% of patients and top 10% of prescribers received or prescribed, respectively, over 80% of the opioid volume in 2013, signaling where to focus intervention efforts.1
  • Researchers at Johns Hopkins University showed the value and effectiveness of pain clinic regulation in reducing the number of opioid prescriptions written by providers engaged in high-risk prescribing.2
  • A team at University of Pittsburgh outlined patient and provider characteristics and patterns of opioid use that increase risk for overdose in Medicaid populations.3
  • Carolinas Medical Center researchers developed an alert in an electronic health record to notify providers about the risk of opioid prescription for patients with factors that signal concern about potential misuse or opioid use disorder.4



  1. Oregon State University; Daniel M. Hartung Pharm. D.; Kim et al, The Concentration of Opioid Prescriptions by Providers and Among Patients in the Oregon Medicaid Program; Psychiatric Services, (2016) 67 397-404.
  2. Johns Hopkins University; G. Caleb Alexander, M.D.; Chang et al. Impact of prescription drug monitoring programs and pill mill laws on high-risk opioid prescribers: A comparative interrupted time series analysis; Drug and Alcohol Dependence, (2016) 165 1-8.
  3. University of Pittsburgh; Gerald Cochran Ph.D.; Gordon et al, Patterns and Quality of Buprenorphine Opioid Agonist Treatment in a Large Medicaid Program; J of Addiction Medicine, (2015) 9 470-477.
  4. Carolinas Medical Center; Rachel Seymour Ph.D.; Seymour et al, Prescription Reporting with Immediate Medication Utilization Mapping (PRIMUM): Development of an Alert to Improve Narcotic Prescribing; BMC Medical Informatics and Decision Making, (2016) 16:111.