HIV Risk Reduction (RR) Efficacy Review: Efficacy Criteria

Risk Reduction

The Prevention Research Synthesis (PRS) Project risk reduction efficacy criteria are used to determine if an HIV behavioral intervention is an Evidence-Based Intervention (EBI). Based on the overall quality of the study, evidence-based risk reduction behavioral interventions are classified as either best-evidence or good-evidence.

Evidence-Based Interventions (EBIs)

Best Evidence

  • Clear description of key aspects
  • Prospective study design
  • Appropriate and concurrent comparison arm
  • Random or minimally biased assignment to study arms
  • Shown to have significant and positive evidence of efficacy.

These interventions are scientifically rigorous and provide the strongest evidence of efficacy.

PRS RR Best ILI/GLI/CPL Criteria pdf icon[PDF – 193 KB]

PRS RR Best CLI Criteria pdf icon[PDF – 217 KB]

Evidence-Based Interventions (EBIs)

Good Evidence

  • Clear description of key aspects
  • Prospective or quasi-prospective study design
  • Appropriate/concurrent comparison arm or historical comparison
  • Random, minimally biased, or moderately biased allocation to study arms
  • Shown to have significant and positive evidence of efficacy

These interventions are scientifically sound and provide sufficient evidence of efficacy.

PRS RR Good ILI/GLI/CPL Criteria pdf icon[PDF – 212 KB]

PRS RR Good CLI Criteria pdf icon[PDF – 220 KB]

Additional Resources