PrEP Best Practices Criteria
The Pre-Exposure Prophylaxis (PrEP) Best Practices criteria are used to determine if an intervention demonstrates sufficient evidence for improving PrEP use and persistence. Because the PrEP research intervention literature is relatively young and efficacy trials are limited in number, after multiple consultations with HIV/STI researchers and a key federal partner – the National Institute of Mental Health (NIMH), the Prevention Research Synthesis (PRS) Project developed two sets of criteria to evaluate PrEP interventions (i.e., Evidence-based and Evidence-informed). These criteria focus on quality of study design, quality of study implementation and analysis, and strength of evidence of findings.
PrEP Evidence-Based Interventions (EBIs)
PrEP Evidence-Based Interventions (EBIs) are interventions that have been tested with a comparison arm (sample ≥ 40 per arm) and have shown significant positive effects for improving PrEP use and persistence. These interventions are considered to be scientifically rigorous and provide the strongest evidence of efficacy. These interventions meet PRS PrEP Evidence-Based criteria pdf icon[PDF – 209 KB].
PrEP Evidence-Informed interventions (EIs)
PrEP Evidence-Informed Interventions (EIs) are interventions evaluated with a comparison arm (sample < 40 but ≥ 25 per arm) or with one-group study designs that have pre-post data. EIs have shown significant positive effects for improving PrEP use and persistence. These interventions are considered promising strategies and, ideally, need to be tested with a comparison group. These interventions meet PRS PrEP Evidence-Informed criteria pdf icon[PDF – 212 KB].